A5077533652- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Child Development and Digital Technology
- Neuroendocrine regulation and behavior
- Child Nutrition and Feeding Issues
- Ubiquitin and proteasome pathways
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Endometriosis Research and Treatment
- Infant Nutrition and Health
- Sirtuins and Resveratrol in Medicine
- Histone Deacetylase Inhibitors Research
- Burn Injury Management and Outcomes
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- Viral-associated cancers and disorders
- Cancer, Hypoxia, and Metabolism
- Neonatal and fetal brain pathology
- Gestational Diabetes Research and Management
- Engineering and Information Technology
- Antioxidant Activity and Oxidative Stress
Hainan Medical University
2023-2025
Guangzhou University of Chinese Medicine
2020-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Foshan Maternity and Child Health Care Hospital
2020-2023
Southern Medical University
2022-2023
Peking University Shenzhen Hospital
2017-2023
Wuhan Third Hospital
2017-2022
Tongren Hospital
2017-2022
Shenzhen KangNing Hospital
2018-2022
Impaired wound healing is one of the major complications diabetes, involving prolonged inflammation, delayed re-epithelialization, and consistent oxidative stress. The detailed mechanism remains unclear, there currently no effective treatment for diabetic healing. In this study, we aim to investigate potential role effect nuclear factor erythroid-2-related factor-2 (Nrf2) activation on vitro experiments in rat macrophages showed that hyperglycemia suppresses Nrf2 activation, resulting stress...
Significance Hyperglycemia induces persistent oxidative stress and superoxide dismutase 2 (SOD2) suppression in neurons. SOD2 is caused by stress-mediated histone methylation subsequent dissociation of Egr1 on the promoter. Maternal diabetes autism-like behavior offspring with amygdala rats, while overexpression ameliorates behavior. Postnatal treatment blood–brain barrier-permeable antioxidant resveratrol partly restores this effect. This study describes a potential mechanism for maternal...
Recent literatures indicate that maternal hormone exposure is a risk factor for autism spectrum disorder (ASD). We hypothesize prenatal progestin may counteract the neuroprotective effect of estrogen and contribute to ASD development, we aim develop method ameliorate exposure-induced autism-like behavior. Experiment 1: Prenatal offspring are treated with resveratrol (RSV) through either or postnatal then used behavior testing other biomedical analyses. 2: norethindrone (NET) ERβ knockdown...
Autism spectrum disorder (ASD) is characterized by impairments in social communication and restricted or repetitive behaviors interests. ASD now diagnosed more than one out of 100 children biased towards males a ratio at least 4:1. Many possible explanations potential causative factors have been reported, such as genetics, sex, environmental factors, although the detailed mechanisms remain unclear. The dams were exposed through oral contraceptives to either vehicle control (VEH) alone,...
Background. Breast cancer is a very common with significant premature mortality in women. In this study, we show that HKDC1 expression breast cells increased significantly. We aim to investigate the detailed mechanism for regulation of and its potential contribution tumorigenesis. Methods. Gene was evaluated by real time PCR, western blotting immunohistochemistry. The PGC1β/SREBP1-mediated investigated using luciferase reporter assay, chromatin immunoprecipitation, siRNA techniques....
Abstract Background Cyanotic congenital heart disease (CHD) in children has been associated with neurodevelopmental abnormalities, although the underlying mechanisms remain largely unknown. Multiple factors are likely involved this process. This research aims to explore potential effects of hypoxia and vascular system-derived outcomes offspring. Methods Mouse aorta endothelial cells (MEC) amygdala neurons were isolated investigate on pro-inflammatory cytokine release, gene expression, redox...
SIRT1 has many important molecular functions in aging, and the estrogen receptors (ERs) have a vasculoprotective effect, although detailed mechanism for roles of ERs vascular aging remains unclear. We found that ERβ expression endothelium was reduced mice, ERα did not change, while activity declined. Further investigation showed regulated by through complexes SIRT1-PPARγ/RXR-p300 bind to PPRE (PPAR response element) site on promoter, declined function mice due compromised phosphorylation at...
We have previously reported that prenatal progestin exposure induces autism-like behavior in offspring through ERβ (estrogen receptor β) suppression the brain, indicating may induce autism spectrum disorders (ASD). In this study, we aim to investigate whether is associated with ASD. A population-based case-control epidemiology study was conducted Hainan province of China. The ASD children were first screened Autism Behavior Checklist (ABC) questionnaire, and then diagnosed by clinical...
Extranodal nasal-type natural killer/T-cell lymphoma (ENKTL) is an Epstein-Barr virus (EBV) associated that progresses rapidly and relapses frequently. Advanced ENKTL multidrug chemoresistant has a poor prognosis. In this study, we aim to develop novel hexokinase domain component 1 (HKDC1)-based antitumor target for involved with the antimetabolic signaling pathway, EBV replication, P-glycoprotein (P-gp) expression. We showed HKDC1 highly upregulated in cells knockdown significantly...
Acute myeloid leukemia (AML) is a heterogeneous disorder of the hematopoietic system with no common genetic "Achilles heel" that can be targeted. Most patients respond well to standard therapy, while majority relapse, and development an effective therapy for AML still urgently needed. In this study, we demonstrated betulinic acid (BA) significantly increased Aryl hydrocarbon receptor (AHR) expression through demethylation on AHR promoter in cells, interacts sequesters ARNT, subsequently...
Multiple myeloma (MM) is an incurable hematologic malignancy due to inevitable relapse and chemoresistance development. Our preliminary data show that MM cells express high levels of PGC1β LDHA. In this study, we investigated the mechanism behind PGC1β-mediated LDHA expression its contribution tumorigenesis, aid in development novel therapeutic approaches for MM. Real-time PCR western blotting were first used evaluate gene different cells, then, luciferase reporter assay, chromatin...
Diabetes significantly delays wound healing through oxidative stress, inflammation and impaired re-epithelialization that lead to defective regulation of the process, although related mechanism remains unclear. Here, we aim investigate potential role for beneficial effect betulinic acid (BA) on diabetic healing.The molecular BA hyperglycemia-mediated gene expression, glucose uptake was evaluated in endothelial, fibroblast muscle cells. Burn injury introduced streptozotocin-induced rats...
Abstract Many studies have shown that vitamin D (VD) deficiency may be a risk factor for neurodevelopmental disorders, such as autism spectrum disorders (ASDs) and schizophrenia, although causative mechanisms remain unknown. In this study, we investigated the potential role effect of VD on maternal diabetes induced autism‐related phenotypes. The in vitro study found enhancing genomic signaling by overexpressing receptor (VDR) human neural progenitor cells ACS‐5003 protects against...
Autism spectrum disorder (ASD) is a clinical of neurodevelopment characterized by deficits in social communication and interaction along with repetitive/stereotyped behaviors. The current diagnosis for autism relies entirely on evaluation has many limitations. In this study, we aim to elucidate the potential mechanism behind establish series biomarkers diagnosis. Here, established an ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry- (UHPLC-QTOF/MS-)...
<b><i>Introduction:</i></b> Progestin, commonly used in oral contraception and preventing preterm birth, elicits various off-target side effects on brain gastrointestinal (GI) functions, yet the precise mechanisms remain elusive. This study aims to probe progestin’s impact GI function anxiety-like behaviors female mice. <b><i>Methods:</i></b> Colon stem cells were utilized explore mechanism underlying progestin 17-hydroxyprogesterone caproate...
Many epidemiology studies have shown that maternal polycystic ovary syndrome (PCOS) results in a greater risk of autism spectrum disorders (ASD) development, although the detailed mechanism remains unclear. In this study, we aimed to investigate potential and provide possible treatment for PCOS-mediated ASD through three experiments: Experiment 1: Real time PCR western blots were employed measure gene expression human neurons, luciferase reporter assay chromatin immunoprecipitation (ChIP)...
Delayed wound healing is one of the major complications diabetes mellitus and characterized by prolonged inflammation, delayed re-epithelialization consistent oxidative stress, although detailed mechanism remains unknown. In this study, we aimed to investigate potential role effect pterostilbene (PTE) hematopoietic stem cells (HSCs) on diabetic healing. Diabetic rats were used measure epigenetic changes in both HSCs peripheral blood mononuclear (PBMCs). A cutaneous burn injury was induced...
Autism spectrum disorders (ASD) have been found to be associated with immune dysfunction and elevated cytokines, although the detailed mechanism remains unknown. In this study, we aim investigate potential mechanisms through a maternal diabetes-induced autistic mouse model. We that offspring epigenetic changes on superoxide dismutase 2 (SOD2) promoter subsequent SOD2 suppression in both hematopoietic stem cells (HSC) peripheral blood mononuclear (PBMC). Bone marrow transplantation of normal...
BACKGROUND:Autism spectrum disorder (ASD) is a complicated neuropsychiatric disease that displays significant heterogeneity. The diagnosis of ASD currently primarily dependent upon descriptions clinical symptoms, and it remains urgent to find biological markers for the detection autism. current study applied urinary metabolic profiling approach characterize phenotypes in ASD. MATERIAL AND METHODS:Urine was obtained from children with their matched healthy siblings. Samples were analyzed...
Autism spectrum disorders (ASD) are a group of neurodevelopmental characterized by impaired skills in social interaction and communication addition to restricted repetitive behaviors. Many different factors may contribute ASD development; particular, oxytocin receptor (OXTR) deficiency has been reported be associated with ASD, although the detailed mechanism remained largely unknown. Epidemiological study shown that maternal diabetes is development. In this study, we aim investigate...
Retinoic acid-related orphan receptor alpha (RORA) suppression is associated with autism spectrum disorder (ASD) development, although the mechanism remains unclear. In this study, we aim to investigate potential effect and mechanisms of RORA on autism-like behavior (ALB) through maternal diabetes-mediated mouse model. Our in vitro study human neural progenitor cells shows that transient hyperglycemia induces persistent oxidative stress-mediated epigenetic modifications subsequent...
Abstract Epidemiological studies have shown that maternal diabetes is associated with autism spectrum disorder development, although the detailed mechanism remains unclear. We previously found induces persistent epigenetic changes and gene suppression in neurons, subsequently triggering autism‐like behavior (ALB). In this study, we investigated potential role effect of hematopoietic stem cells (HSCs) on diabetes–mediated gastrointestinal (GI) dysfunction ALB a mouse model. show vitro...