A5101821777- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Associations and Epidemiology
- Artificial Intelligence in Healthcare
- Vitamin C and Antioxidants Research
- Cardiovascular Health and Risk Factors
- Ion Channels and Receptors
- Climate Change and Health Impacts
- Cytokine Signaling Pathways and Interactions
- Adipose Tissue and Metabolism
- Vitamin D Research Studies
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Lipid metabolism and disorders
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Sirtuins and Resveratrol in Medicine
- Education and Work Dynamics
- Tryptophan and brain disorders
- Phytochemicals and Antioxidant Activities
Guangdong Medical College
2015-2025
Guangzhou Medical University
2022-2024
Third Affiliated Hospital of Guangzhou Medical University
2023
Weatherford College
2020
Songshan Lake Materials Laboratory
2019
Henan University Huaihe Hospital and Huaihe Clinical Institute
2015
Zero to Three
2015
Linyi People's Hospital
2014
Southern Medical University
2014
Ruijin Hospital
2014
Gastric cancer (GC) has one of the highest mortality rates malignancies globally. Currently, ciRS-7, a novel circular RNA, emerged as potential sponge for miR-7. However, few studies on ciRS-7 in GC have been performed. In this study, we investigated clinical significance and function GC. First, expression levels 102 primary tissues matched para-carcinoma were evaluated relevance was confirmed an independent validation cohort (n = 154). Second, effects miR-7, PTEN, PI3K evaluated. Finally,...
Inflammation and obesity have been widely recognized to play a key role in Diabetes mellitus (DM), there exists complex interplay between them. We aimed clarify the relationship inflammation DM, as well mediating of relationship.
Impaired wound healing is one of the major complications diabetes, involving prolonged inflammation, delayed re-epithelialization, and consistent oxidative stress. The detailed mechanism remains unclear, there currently no effective treatment for diabetic healing. In this study, we aim to investigate potential role effect nuclear factor erythroid-2-related factor-2 (Nrf2) activation on vitro experiments in rat macrophages showed that hyperglycemia suppresses Nrf2 activation, resulting stress...
Background Multifaceted factors play a crucial role in the prevention and treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to utilize multifaceted indicators construct MASLD risk prediction machine learning models explore core within these models. Methods were constructed based on seven algorithms using all variables, insulin-related demographic characteristics other indicators, respectively. Subsequently, partial dependence plot(PDP) method...
Abstract Background LncRNA was known to be closely associated with the progression of human tumors. The role lncRNA LIFR-AS1 in pathogenesis and gastric tumor is still unclear. aim this study investigate function underlying mechanism cancer. Methods QRT-PCR used evaluate expression LIFR-AS1, miR-29a-3p COL1A2 tissues cells. Western blotting protein CCK-8 assay, transwell assay flow cytometry were roles cell proliferation, invasion, migration apoptosis. relationship among assessed by...
We aimed to evaluate whether depression is associated with increased risk of dietary inflammatory index (DII) or energy-adjusted DII (E-DII) and the association partly explained by insulin resistance (IR).Base on National Health Nutrition Examination Survey (NHANES) 2005-2018. Univariate analyses continuous categorical variables were performed using t-test, ANOVA, χ2 test, respectively. Logistic regression was used analyze relationship between E-DII in three different models. Mediation...
Abstract The dietary inflammatory index (DII) is a measure of the potential diet and closely associated with insulin resistance (IR) stroke. And IR may play an important role in development Therefore, this study aimed to evaluate relationship between DII stroke risk while delving into association. We analyzed data from National Health Nutrition Examination Survey (NHANES) 2005 2018, performing weighted univariate analyses, logistic regression, mediation analyses. At baseline, 3.89%...
Abstract Objective Bayesian network (BN) models were developed to explore the specific relationships between influencing factors and type 2 diabetes mellitus (T2DM), coronary heart disease (CAD), their comorbidities. The aim was predict occurrence diagnose etiology using these models, thereby informing development of effective prevention control strategies for T2DM, CAD, Method Employing a case-control design, study compared individuals with comorbidities (case group) healthy counterparts...
Objectives In this study, we aimed to clarify the relationship between physical activity (PA) and diabetes mellitus (DM), as well mediating role of Systemic Immune-Inflammatory Index (SII) in relationship. Design A cross-sectional study. Setting National Health Nutrition Examination Survey (NHANES) data collection took place USA at participants’ homes mobile examination centres with specialised equipment. Participants The study population consisted 9493 American adults aged 20 above from...
Objectives: Farnesoid X receptor (FXR) activation is involved in ameliorating inflammatory bowel disease (IBD), such as ulcerative colitis (UC), and regulation may be its mechanism. Ginsenoside Rc (Rc) a major component of Panax ginseng, it plays an excellent role the anti-inflammatory processes. Our aim to explore alleviative effect on dextran sulfate sodium (DSS)-induced inflammation deficiencies barrier function based FXR signaling. Materials Methods:In vitro, we treated human intestinal...
Apelin is an endogenous ligand for the G protein-coupled receptor APJ. The association between apelin and cardiac modeling has been reported. However, if serum affect left ventricular hypertrophy (LVH) prevalence in hypertensive patients remains unknown.We enrolled 344 untreated patients. presence of LVH was determined by echocardiography. blood drawn from these level detected. To study direct effect on hypertrophy, cardiomyocytes were cultured transfected with gene. Morphometric analysis...
Abstract Aim The association of polymorphisms in the three genes SOCS3, JAK2 and STAT3 with genetic susceptibility to type 2 diabetes mellitus (T2DM) was explored, its interaction environmental factors such as hypertension triglycerides analyzed. Methods Hardy–Weinberg balance test used analyze random population. analysis SNPs T2DM performed using Pearson’s chi-square test. Haplotype frequency distribution, SNPs-SNPs were analyzed by logistic regression. Results genotype distribution...
Abstract Vitamin C is an important micronutrient for human. Association between vitamin and trouble sleeping was less studied. Therefore, the purpose of this study to investigate possible link in serum sleeping. The cross-sectional data derived from National Health Nutrition Examination Survey (NHANES, 2017–2018). Trouble measured by asking participants: “Have you ever told doctor had sleeping”. Responses question “yes” or “no”. obtained measuring samples. We used multivariable binary...