A5100646304- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Atherosclerosis and Cardiovascular Diseases
- Psoriasis: Treatment and Pathogenesis
- Microscopic Colitis
- Inflammatory Bowel Disease
- S100 Proteins and Annexins
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Antibiotic Resistance in Bacteria
- Wind and Air Flow Studies
- Infrared Thermography in Medicine
- Coal and Its By-products
- Hydraulic flow and structures
- Viral Infectious Diseases and Gene Expression in Insects
- Chemotherapy-induced cardiotoxicity and mitigation
- Seismic and Structural Analysis of Tall Buildings
- Business and Economic Development
- Antibiotic Use and Resistance
- Biological Research and Disease Studies
- Morinda citrifolia extract uses
- Infectious Encephalopathies and Encephalitis
- Cardiac, Anesthesia and Surgical Outcomes
Beijing Tongren Hospital
2014-2025
Capital Medical University
2014-2025
Guangdong Medical College
2015-2024
Guangxi University
2024
Second Military Medical University
2011-2020
Sichuan University
2018
West China Hospital of Sichuan University
2018
Shanghai Changzheng Hospital
2015-2017
Ningbo Medical Center Lihuili Hospital
2014
Zhejiang Provincial People's Hospital
2011
Gastric cancer (GC) has one of the highest mortality rates malignancies globally. Currently, ciRS-7, a novel circular RNA, emerged as potential sponge for miR-7. However, few studies on ciRS-7 in GC have been performed. In this study, we investigated clinical significance and function GC. First, expression levels 102 primary tissues matched para-carcinoma were evaluated relevance was confirmed an independent validation cohort (n = 154). Second, effects miR-7, PTEN, PI3K evaluated. Finally,...
Aberrantly methylated genes are increasingly being established as biomarkers for the detection of colorectal cancer (CRC). In present study, methylation levels secreted frizzled-related protein gene 2 (SFRP2), GATA binding 4/5 (GATA4/5), N-Myc downstream-regulated 4 (NDRG4) and vimentin (VIM) promoters were evaluated their use markers in noninvasive CRC. Methylation-specific polymerase chain reaction was performed to analyze promoter CpG SFRP2, GATA4/5, NDRG4 VIM fecal DNA 56 patients with...
Human papillomavirus (HPV) infection is closely related to upper respiratory mucosal lesions, and the most common disease adult papilloma, which has a certain probability of cancer transformation.This study conducted in vitro tissue cell experiments explore inflammatory mechanisms associated with HPV + laryngeal papilloma. We compared differential expression AIM2 IL-1β between (High-risk) negative positive papilloma patients. In were investigate differences AIM2, Caspase-1, HPV- HPV+ cells....
This paper describes a procedure for evaluating the effect of changes to existing residential structural vulnerability on hurricane-induced building damage and expected insurance losses. Two scenario-based models are proposed modeling in stock due improvements envelope performance, both new construction. The influence over time losses can then be obtained. cost retrofit or additional upgrade construction included hurricane risk-cost-benefit analysis assess economic viability this other...
Gastric cancer (GC) is one of the most frequently diagnosed malignancies in East Asia, particularly China, and remains second leading cause cancer-associated mortality worldwide. However, no effective plasma biomarkers have been identified for diagnosis patients with GC. The aim this study was to investigate DNA methylation status ring finger protein 180 (RNF180), secreted frizzled-related 2 (SFRP2) death-associated kinase 1 (DAPK1) genes samples 57 GC 42 control individuals malignant...
Aim: Immunologic dysfunction was recently found to be one of the most important mechanisms underlying initiation and development atherosclerosis. Thymus involution can contribute immune disturbance disequilibrium T-cell subsets. This study aimed explore whether recent thymic emigration (RTE) is impaired in patients with coronary artery disease (CAD).Methods: Content signal-joint T cell receptor excision circles (sj-TREC) lymphocytes, a molecular marker RTE, assessed among CAD age-matched...
Gastric cancer (GC) is the third leading cause of cancer-associated mortality. In a previous study, we identified that α-enolase (ENO1) promoted cell migration in GC, but underlying molecular mechanisms remain to be fully elucidated. present small interfering RNAs were interfere with ENO1 expression. The cDNA expression profiling was performed using an Affymetrix mRNA array platform identify genes may associated human GC line MGC-803. differentially expressed (DEGs) reverse...
Endothelial progenitor cells (EPCs) are shown to participate in the pathological processes of atherosclerosis. While Vitamin D and its receptor axis might exert some effects on EPCs' function. But their exact relationship with clinical patients is still elusive, which inspired us explore potential association vitamin (VDR) expression circulating EPCs serum levels among coronary artery disease (CAD).Two hundred CAD after admission hospital one healthy controls were enrolled. Medical history...
The aim of this paper is to investigate effect and mechanism Danhong injection (DH) on angiogenesis in the diabetic hind limb ischemia mouse model. Thirty ischemic model mice ten normal mice, established by intraperitoneal (i.p.) streptozotocin (STZ) or PBS ligation/excision femoral artery, then twenty all were evenly randomized saline (control, n = 10) DH i.p. (2 mL/kg weight for 7 days, groups. Limb perfusion recovery blood hydrogen sulfide (H2S) vessel regeneration lower vascular...
Abstract Sustained exposure to high glucose (HG) results in dysfunction of vascular endothelial cells. Hence, diabetic patients often suffer from secondary damages, such as sclerosis and thrombogenesis, which may eventually cause cardiovascular problems. Thus, elucidating how HG cell damage finding an approach for prevention are important prevent treat damages patients. In the current study, we first showed that 72‐hour HG‐decreased hsa‐miRNA‐29a increased expression Bcl‐2 associated X...
Immune system biomarkers in cancer pathogenesis offer new therapeutic avenues, as seen cytokine (CK) profiles of laryngeal and hypopharyngeal tumors. A retrospective analysis was conducted on 58 patients with tumors 27 benign vocal cord lesions to explore the role serum CKs these diseases’ characteristics immunotherapy. The differences levels 12 cytokines were measured. Additionally, study examined correlation between T helper cells (Th)1/Th2 clinical immunotherapy efficacy cancers. results...
ABSTRACT The risk difference (RD) between the secondary infection, given primary and infection can be a useful measure of change in rates infection. It plays an important role pharmacology epidemiology. method variance estimate recovery (MOVER) is used to construct confidence intervals (CIs) for RD. Seven types CIs binomial proportion are introduced obtain MOVER‐based simulation studies show that Agresti‐Coull CI, score incorporating continuity correction Clopper Pearson Bayesian credibility...
This paper presents an approach for evaluating directionality effects both wind speeds and loads in hurricane-prone regions. The focus of this study is on directional low-rise structures. Using event-based simulation, hurricane are determined open-terrain condition at various locations the southeastern United States. speed (or load) factor, defined as ratio N-year mean recurrence interval (MRI) each direction to non-directional MRI load), less than one but increases toward unity with...