A5069038478- Atherosclerosis and Cardiovascular Diseases
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- T-cell and B-cell Immunology
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Healthcare and Venom Research
- Angiogenesis and VEGF in Cancer
- Diabetic Foot Ulcer Assessment and Management
- Adrenal Hormones and Disorders
- Pharmacological Effects of Natural Compounds
- Sodium Intake and Health
- Mast cells and histamine
- Receptor Mechanisms and Signaling
- Traditional Chinese Medicine Analysis
- Biochemical effects in animals
- Biomarkers in Disease Mechanisms
- Cardiac Imaging and Diagnostics
- Whipple's Disease and Interleukins
- Blood Pressure and Hypertension Studies
- Traditional Chinese Medicine Studies
- Genetics, Aging, and Longevity in Model Organisms
- Cardiac Valve Diseases and Treatments
Second Military Medical University
2015-2023
Shanghai Changzheng Hospital
2015-2022
Aim: Immunologic dysfunction was recently found to be one of the most important mechanisms underlying initiation and development atherosclerosis. Thymus involution can contribute immune disturbance disequilibrium T-cell subsets. This study aimed explore whether recent thymic emigration (RTE) is impaired in patients with coronary artery disease (CAD).Methods: Content signal-joint T cell receptor excision circles (sj-TREC) lymphocytes, a molecular marker RTE, assessed among CAD age-matched...
Previous studies have found that thymus is involved in the process of hypertension. However, whether transplantation alleviates target organ damage hypertensive mice remains unknown. The aim this study was to evaluate effects on blood pressure and changes with Mice were randomly divided into normal control group (Con), (HTN) (HTN + Trans). Thymus neonatal transplanted renal capsule group. After transplantation, mouse tail noninvasive measured heart function evaluated weekly. Then euthanized...
We aim to explore the effects and mechanisms of Jinlida granules on dysfunction hypothalamic-pituitary-thyroid (HPT) axis in diabetic rats induced by streptozotocin.A total 48 SD were randomized into normal control group (NC, n = 6) (n 42). Rats randomly divided diabetes mellitus (DM) group, low, medium, high doses (JL, JM, JH), medium dose plus Tongxinluo (JM + T), metformin (Met), Saxagliptin (Sax) 6 each group). Diabetic obtained intraperitoneal injection streptozotocin sacrificed at 8...
Endothelial progenitor cells (EPCs) are shown to participate in the pathological processes of atherosclerosis. While Vitamin D and its receptor axis might exert some effects on EPCs' function. But their exact relationship with clinical patients is still elusive, which inspired us explore potential association vitamin (VDR) expression circulating EPCs serum levels among coronary artery disease (CAD).Two hundred CAD after admission hospital one healthy controls were enrolled. Medical history...
The aim of this paper is to investigate effect and mechanism Danhong injection (DH) on angiogenesis in the diabetic hind limb ischemia mouse model. Thirty ischemic model mice ten normal mice, established by intraperitoneal (i.p.) streptozotocin (STZ) or PBS ligation/excision femoral artery, then twenty all were evenly randomized saline (control, n = 10) DH i.p. (2 mL/kg weight for 7 days, groups. Limb perfusion recovery blood hydrogen sulfide (H2S) vessel regeneration lower vascular...
The aim of this study was to evaluate thymus function in mice with hypertension. A total 60 C57BL/6J were randomized into control, sham surgery and two‑kidney, one‑clip groups (n=20 each). At 4 or 8 weeks after surgery, sacrificed, blood, spleens, kidneys thymuses harvested. results reverse transcription-quantitative polymerase chain reaction analysis revealed that the mRNA levels Forkhead box protein N1 (Foxn1) autoimmune regulator (AIRE) tissue from HTN group significantly lower than those...
Aims: The aim of this study was to evaluate the effects thymus transplantation on blood pressure and target organ pathophysiological changes in mice with hypertension.Main methods: Mice were randomly divided into control group (Con, n = 15), hypertensive (HTN, 15) (HTN + Trans, 15). Thymus neonatal transplanted renal capsule group. After transplantation, mouse tail noninvasive measured heart function evaluated. Then sacrificed organs or tissues harvested.Key findings: HTN+Trans lower than...