A5101996039- Cancer-related Molecular Pathways
- Neurogenesis and neuroplasticity mechanisms
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Neuroblastoma Research and Treatments
- Intensive Care Unit Cognitive Disorders
- Galectins and Cancer Biology
- Apelin-related biomedical research
- Neurological Disease Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Neurogenetic and Muscular Disorders Research
- Epigenetics and DNA Methylation
- Cardiac Ischemia and Reperfusion
- FOXO transcription factor regulation
- Kruppel-like factors research
- Medicinal Plants and Bioactive Compounds
- Immune Response and Inflammation
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Toxoplasma gondii Research Studies
- Biological and pharmacological studies of plants
- Sirtuins and Resveratrol in Medicine
- Pain Mechanisms and Treatments
Shanghai Changzheng Hospital
2016-2022
Nantong University
2007-2012
Affiliated Hospital of Nantong University
2007-2012
Fudan University
2011
FOXO3a (Forkhead Class box O3a), as an important direct target of the phosphatidylinositol 3-kinase (PI3K)/protein B (Akt) pathway, which regulates cell survival and cell-cycle progression. Recent reports showed that could inhibit progression at G1/S transition by controlling transcription cyclin-dependent kinase inhibitor p27(kip1) , is also a key regulator mammalian neurogenesis. To elucidate expression role in nervous system lesion repair, we performed acute spinal cord contusion injury...
Systematic proteomic studying of the mechanism hepatocellular carcinoma (HCC) metastasis remains challenging. We performed comparative and pathway analysis four human metastatic HCC cell lines to identify metastasis-associated proteins. These had a similar genetic background but with an increasing potential metastasis. Using combination two dimensional electrophoresis (2-DE) MALDI-TOF mass spectrometry, total 125 proteins their post-translational modification forms or isoforms were found be...
Senile osteoporosis increases fracture risks. Bone marrow stromal cells (BMSCs) are sensitive to aging. Deep insights into BMSCs aging vital elucidate the mechanisms underlying age-related bone loss. Recent advances showed that is associated with aberrant DNA methylation of many susceptible genes. Galectin-1 (Gal-1) has been proposed as a mediator functions. In our previous study, we Gal-1 was downregulated in aged and global deletion mice caused loss via impaired osteogenesis potential...
Aims: The aim of this study was to evaluate the effects thymus transplantation on blood pressure and target organ pathophysiological changes in mice with hypertension.Main methods: Mice were randomly divided into control group (Con, n = 15), hypertensive (HTN, 15) (HTN + Trans, 15). Thymus neonatal transplanted renal capsule group. After transplantation, mouse tail noninvasive measured heart function evaluated. Then sacrificed organs or tissues harvested.Key findings: HTN+Trans lower than...