A5114121189- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Metabolomics and Mass Spectrometry Studies
- Cancer-related Molecular Pathways
- Spinal Cord Injury Research
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Neuroblastoma Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Immunotherapy and Immune Responses
- Wnt/β-catenin signaling in development and cancer
- Protease and Inhibitor Mechanisms
- Mitochondrial Function and Pathology
- Calpain Protease Function and Regulation
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Retinoids in leukemia and cellular processes
Nantong University
2011-2025
Taizhou People's Hospital
2025
Nanjing Medical University
2025
Maastricht University
2019-2024
Wannan Medical College
2024
Chinese Academy of Tropical Agricultural Sciences
2023
Rubber Research Institute
2023
Shanxi University
2019-2021
Shanxi University of Traditional Chinese Medicine
2020
Beijing Normal University
2016-2019
Tumour metastasis is the major cause of breast cancer mortality. Myricetin, a natural polyphenol, found in teas, wines, and berries. The pharmacodynamic action molecular mechanism myricetin on remain unknown. Here, we investigated effect MDA-Mb-231Br cell viability, migration, invasion, 4T1 mouse lung models. MMP-2/9 protein expression ST6GALNAC5 were analysed using western blot assays quantitative real-time polymerase chain reaction, respectively. Cell migration invasion detected by...
Cells often adopt different phenotypes, dictated by tissue-specific or local signals such as cell-cell and cell-matrix contacts molecular micro-environment. This holds in extremis for macrophages with their high phenotypic plasticity. Their broad range of functions, some even opposing, reflects heterogeneity, a multitude subsets has been described tissues diseases. Such micro-environmental imprint cannot be adequately studied single-cell applications, cells are detached from context, while...
BACKGROUND: The metabolic alterations occurring within the arterial architecture during atherosclerosis development remain poorly understood, let alone those particular to each tunica. We aimed first identify, in a spatially resolved manner, specific changes plaque, media, adventitia, and cardiac tissue between control atherosclerotic murine aortas. Second, we assessed their translatability human plasma for cardiovascular risk estimation. METHODS: In this observational study, mass...
Abstract Background Cancer cachexia is a multifactorial metabolic syndrome characterized by systemic inflammation and ongoing skeletal muscle loss resulting in weakness, poor quality of life, decreased survival. Whereas lipid accumulation associated with cancer as well the prognosis patients, surprisingly little known about nature lipids that accumulate during cachexia, whether this related to inflammation. We aimed identify types distributions intramyocellular patients without cachexia....
Abstract Background Metabolic reprogramming is a common phenomenon in tumorigenesis and tumor progression. Amino acids are important mediators cancer metabolism, their kinetics tissue far from being understood completely. Mass spectrometry imaging capable to spatiotemporally trace endogenous metabolites biological specimens. In this research, we studied L-[ring- 13 C 6 ]-labeled phenylalanine tyrosine human non-small cell lung carcinoma (NSCLC) xenografted mouse model using matrix-assisted...
Atherosclerosis is the major contributor to cardiovascular diseases. It a spatially and temporally complex inflammatory disease, in which intravascular accumulation of plethora lipids considered play crucial role. To date, both composition local distribution involved have not been thoroughly mapped yet. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) enables analyzing visualizing hundreds lipid molecules within plaque while preserving each lipid's specific...
Spatial analysis of lipids in inflammatory microenvironments is key to understand the pathogenesis infectious disease. Granulomatous inflammation a hallmark leishmaniasis and changes host parasite lipid metabolism have been observed at bulk tissue level various infection models. Here, mass spectrometry imaging (MSI) applied spatially map hepatic composition following with Leishmania donovani, an experimental mouse model visceral leishmaniasis.Livers from naïve L. donovani-infected C57BL/6...
Background: Antibodies isolated from cancer patients have been used to identify genes encoding tumor-associated antigen epitopes relevant immune responses in patients. In this report, we an immunoglobulin G (IgG) purified serum of a patient with breast its corresponding epitope, gene, and protein—retinoblastoma-binding protein-1-like protein-1 (RBP1L1)—and determined whether it is potential molecular marker for various cancers. Methods: IgG the was screen MCF-7 cell complementary DNA (cDNA)...
The passage number is an important factor when designing the cell line-based experiment. Although HT29 cells were widely used in laboratory for colorectal cancer studies, impact of on was still unknown. In this study, phenotypic assay and metabolomic approach applied to analyze systemic effects numbers (passage 4, 10, 16) cells. results showed that increased affected cycle distribution also decreased proliferation migration ability analysis coupled with heatmap hierarchical cluster obvious...
ABSTRACT Far Upstream Element (FUSE) Binding Protein 1 (FBP1), first identified as a single‐stranded DNA (ssDNA) binding protein that binds to the FUSE, could modulate c‐myc mRNA levels and also has been shown regulate tumor cell proliferation replication of virus. Typically, FBP1 active translation p27kip1 (p27) participate in growth. However, expression roles peripheral system lesions repair are still unknown. In our study, we found was relatively higher normal sciatic nerves,...