A5101889537- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Kruppel-like factors research
- Nerve injury and regeneration
- Cancer-related gene regulation
- Cerebrovascular and Carotid Artery Diseases
- Heat shock proteins research
- Intracranial Aneurysms: Treatment and Complications
- interferon and immune responses
- Calpain Protease Function and Regulation
- Biochemical effects in animals
- Neurological Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Neurosurgical Procedures and Complications
- Immune Response and Inflammation
- Phagocytosis and Immune Regulation
- Connexins and lens biology
- Down syndrome and intellectual disability research
- Nuclear Receptors and Signaling
Affiliated Hospital of Nantong University
2014-2024
Nantong University
2014-2024
Shanghai Jiao Tong University
2023
Xuzhou Medical College
2023
Indiana University School of Medicine
2014
Indiana University Health
2014
Beth Israel Deaconess Medical Center
2014
National Institutes of Health
2014
Harvard University
2014
University of California, San Francisco
2014
Abstract Abnormal hyperphosphorylation of tau is pivotally involved in the pathogenesis Alzheimer's disease (AD) and related tauopathies. Glycogen synthase kinase 3β (GSK-3β) a primary that most implicated pathology AD. However, exact molecular nature GSK-3β AD unclear. In present study, we found was truncated at C-terminus correlated with over-activation calpain I brain. Truncation positively hyperphosphorylation, tangles score Braak stage human Calpain proteolyzed vitro C-terminus, leading...
Hyperphosphorylation and dysregulation of exon 10 splicing Tau are pivotally involved in pathogenesis Alzheimer disease (AD) and/or other tauopathies. Alternative 10, which encodes the second microtubule-binding repeat, generates isoforms containing three four repeats, termed 3R-Taus 4R-Taus, respectively. Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) lies at Down syndrome critical region chromosome 21. Overexpression this may contribute to early pathology via...
Abstract Objective To explore the mechanism involved in variable phenotypes of epilepsy models induced by γ‐aminobutyric acid type A γ2 subunit ( GABRG2 ) mutations. Methods The zebrafish carrying wild‐type (WT) , mutant GABRG2(P282S) GABRG2(F343L) and GABRG2(I107T) were established Tol2kit transgenesis system Gateway method. Behavioral analysis different transgenic was performed with DanioVision Video‐Track framework brain activity analyzed field potential recording MD3000 Bio‐signal...
Microtubule-associated protein tau is found to be accumulated and aggregated in the brains of individuals with Alzheimer's disease related tauopathies. Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Dyrk1A) overexpressed Down syndrome may play a critical role early onset pathology this disease. To investigate effect Dyrk1A on expression, we co-expressed different isoforms HEK-293FT cells measured mRNA levels using RT-PCR Western blots, respectively. We further investigated...
The p75 neurotrophin receptor (p75NTR), a member of tumor necrosis factor superfamily, involves in neuronal apoptosis after intracerebral hemorrhage (ICH). It has been previously demonstrated that phosphorylation p35 is crucial for fighting against the proapoptotic p25/CDK5 signaling apoptosis. Then, ICH models rats and primary cortical neurons, we found expressions p75NTR, p-histone H1 (the kinase activity CDK5), p25, Fas-associated phosphatase-1 (FAP-1), phosphorylated myocyte enhancer 2D...
SYF2, known as CCNDBP1‐interactor or p29 , is likely involved in pre‐mRNA splicing and cell cycle progression. The present study was designed to elucidate dynamic changes SYF2 expression distribution the cerebral cortex a lipopolysaccharide (LPS)‐induced neuroinflammation rat model. It found that induced strongly active astrocytes after LPS injection. In vitro studies showed upregulation of might be activation C6 cells challenge neuronal apoptosis conditioned media challenge. addition, with...
Reactive astrogliosis is a key hallmark of inflammatory responses in the pathogenesis brain injury, including Parkinson’s disease (PD), but its role and regulatory mechanisms are not fully understood. Pannexin 1 (Panx 1) membrane channel that mediates substance release many neurodegenerative diseases. However, astrocyte Panx regulation PD-like neuroinflammation remains elusive. Here, we characterized expression isolated primary astrocytes 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine...
Objective: to evaluate whether postoperative heart rate variability (HRV) predicts short-term outcomes in patients undergoing coil embolization of ruptured aneurysms.Methods: Consecutive receiving endovascular coiling treat aneurysmal subarachnoid hemorrhage (SAH) were retrospectively reviewed between November 2011 and December 2014 the authors' institution. Heart (HR) blood pressure (BP) recorded initial 24 h after treatment extracted along with other clinical data. HR BP (BPV) determined...
The present study was conducted to evaluate the effect of postoperative blood pressure (BP) variability on functional outcome in patients after coil embolization ruptured aneurysms.The authors retrospectively reviewed their database undergoing endovascular coiling treat subarachnoid hemorrhage (SAH) between November 2011 and December 2014. BP values were recorded every 2 hours initial 24 obliteration aneurysms. determined as standard deviation (SD) successive variation (SV). Clinical at...