A5054587547- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
- Selenium in Biological Systems
- Synthesis and properties of polymers
- Inflammasome and immune disorders
- Ginseng Biological Effects and Applications
- Animal Nutrition and Physiology
- Circular RNAs in diseases
- Carbon dioxide utilization in catalysis
- Liver Disease Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Polymer composites and self-healing
- Immune Cell Function and Interaction
- Epoxy Resin Curing Processes
- Sperm and Testicular Function
- Ferroptosis and cancer prognosis
- Peroxisome Proliferator-Activated Receptors
- Animal Virus Infections Studies
- Lipid metabolism and disorders
- Medicinal Plant Pharmacodynamics Research
- Heat shock proteins research
- Radiomics and Machine Learning in Medical Imaging
- Polymer Nanocomposites and Properties
Zhongkai University of Agriculture and Engineering
2017-2025
Guangzhou Medical University
2020-2025
Guangzhou Chemistry (China)
2024
Chinese Academy of Sciences
2024
First Affiliated Hospital of Guangzhou Medical University
2020-2024
Yuhuangding Hospital
2024
University of Chinese Academy of Sciences
2024
State Key Laboratory of Oral Diseases
2023
Anhui Medical University
2022-2023
First Affiliated Hospital of Anhui Medical University
2022-2023
Alzheimer’s disease (AD) is the most common neurodegenerative disease. The accumulation of amyloid beta (A β ) main pathology AD. Metformin, a well-known antidiabetic drug, has been reported to have AD-protective effect. However, mechanism still unclear. In this study, we tried figure out whether metformin could activate insulin-degrading enzyme (IDE) ameliorate A -induced pathology. Morris water maze and Y-maze results indicated that improve learning memory ability in APP swe /PS1 dE9...
Cycloaliphatic epoxy resins are known for their synthesis process that eliminates hydrolyzable chlorine, thus avoiding the hydrolysis of chlorine to hydroxyl groups in conventional epoxies, which is very favorable preparation low dielectric resins. The curing using active ester generates no groups, also indicating a promising approach producing However, resistance cycloaliphatic nucleophilic reactions restricts it from reacting usually only with anhydrides. This study investigates reactivity...
Heat stress can cause immune organ dysfunction and apoptosis. Polysaccharide of Atractylodes macrocephala Koidz may have protective effects on organs. In this study, we established chicken models Koidz-heat interaction detected the oxidative index, activities mitochondrial complexes ATPases as well ultrastructure in spleens. Expression levels cytokines, dynamics- apoptosis-related genes were also measured. result, heat increased expression interleukin 1 tumour necrosis factor-alpha decreased...
Ferroptosis is a newly discovered form of cell death due to iron-dependent lipid peroxidation. In animal breeding, many environmental factors could lead oxidative stress, which in turn reduce immunity and production performance. Polysaccharide Atractylodes macrocephala Koidz (PAMK) has antioxidation, immunomodulatory, inflammatory modulating effects. For investigating the effect PAMK on splenic ferroptosis gosling caused by lipopolysaccharide (LPS), 40 one-day-old Magang goslings were...
Abstract Chronic obstructive pulmonary disease (COPD) is a serious chronic lung disease. Schisandrin A (SchA) one of the most important active ingredients in Schisandra chinensis and has been used to treat various diseases several countries. Here, we studied pharmacological effect SchA on airway inflammation induced by cigarette smoke (CS) explored therapeutic mechanism COPD model mice. Our results showed that treatment significantly improved function CS-induced mice reduced recruitment...
The bursa of Fabricius (BF) plays crucial roles in the goslings’ immune system. During waterfowl breeding, presence lipopolysaccharides (LPSs) environment can induce inflammatory damage geese. Polysaccharides Atractylodes macrocephala Koidz (PAMKs), as main active component Chinese medicine macrocephala, have significant immune-enhancing effects. Accordingly, this study intended to investigate effect PAMKs on LPS-induced BF injury goslings. Two hundred 1-day-old goslings (half male and half...
Acute lung injury (ALI) has high morbidity and mortality. Lifei Qingchang Tang (LFQCT), a traditional Chinese medicine, antioxidant anti-inflammatory properties but its mechanism in ALI remains unclear. In vitro, LFQCT reduced intracellular Ca2+, ROS, NO LPS-induced RAW 264.7 cells, suppressed pro-inflammatory mediators (TNF-α, IL-1β, IL-6), iNOS, COX-2, blocked phosphorylation of IKK-α/β, p65, ERK1/2, JNK1/2, p38. It also inhibited p65 activation nuclear translocation. vivo, attenuated mice...
As companion animals, felines play an important role in human's family life, and their healthcare has attracted great attention. Viruses such as feline calicivirus (FCV), herpesvirus 1 (FHV-1), parvovirus virus (FPV) are the most common pathogens that cause severe infectious disease baby cats. Thus, preclinical detection intervention of these three viruses is effective means to prevent diseases minimize danger condition. In this study, a triplex TaqMan quantitative real-time polymerase chain...
The polysaccharide of Atractylodes macrocephala Koidz (PAMK) is recognized as an immune enhancer, with anti-cancer, anti-tumour, lymphocyte-activating and lymphocytes proliferation-inducing effects. For investigating the mechanism that PAMK alleviates decline in T cell activation induced by CTX, 24 6-week-old BALB/c female mice were randomly divided into four groups (C, PAMK, + CTX). spleen index, splenocytes morphology death, cytokine concentration, activating factors (CD25, CD69, CD71),...
Geese evolved from migratory birds, and when they consume excessive high-energy feed, glucose is converted into triglycerides. A large amount of triglyceride deposition can induce incomplete oxidation fatty acids, leading to lipid accumulation in the liver subsequent formation liver. In Chaoshan region Guangdong, China, Shitou geese develop a unique form through 24 h overfeeding brown rice. To investigate mechanisms underlying geese, we collected samples normally fed overfed geese. The...
Skeletal muscle is a critical component of goose meat and significant economic trait geese. The regulatory roles miRNAs lncRNAs in the maturation stage skeletal are still unclear. Therefore, this study conducted experiments on leg muscles Magang geese at two stages: 3-day post-hatch (P3) 3 months (M3). Morphological observations revealed that from P3 to M3, fibers mainly underwent hypertrophy maturation. became thicker, nuclear density decreased, nuclei moved towards fiber edges....
Lipopolysaccharide (LPS) can induce systemic inflammation and affect the growth development of poultry. As a kind traditional Chinese medicine, polysaccharide Atractylodes macrocephala Koidz (PAMK) effectively improve performance animals immunity animal bodies.
Polysaccharide of Atractylodes macrocephala Koidz (PAMK) has been well recognized as an immune enhancer that can promote lymphocyte proliferation and activate cells. The purpose this study was to evaluate the effects PAMK on humoral cellular functions in immunosuppressed geese. Geese Control group were provided with normal feed, 400 mg·(kg body weight)−1 PAMK, cyclophosphamide (CTX) injected 40 cyclophosphamide, while CTX+PAMK received combination CTX. Spleen development percentages...
Polysaccharide of Atractylodes macrocephala Koidz (PAMK) has been reported to have beneficial effects on regulation immune responses in mammals and poultry. Nonetheless, the immunoregulatory mechanism action PAMK remains unclear. The Toll-like receptor 4 (TLR4) signaling cascade proved as a classic polysaccharide-regulated pathway. aim this study was explore TLR4 pathway spleen function mice. Ninety-six 5-week-old BALB/c female mice were randomly allocated into four groups with three...
Polysaccharide Of Atractylodes Macrocephala Koidz (PAMK) has been proved to have anti-cancer, antitumor, anti-inflammation function and improve the immune level of organism. The miRNA plays a very important role in regulating by negatively regulate expression target genes. To explore molecular mechanism PAMK active lymphocytes, thirty 61-d-old geese were randomly divided into 4 groups (C, CTX, PAMK, PAMK+CTX). thymus morphology, serum granulocyte-macrophage colony-stimulating factor...
Non-alcoholic fatty liver disease (NAFLD) is increasingly prevalent, but treatment options are limited. Previous studies have demonstrated the hepatoprotective effects of Polysaccharide Atractylodes macrocephala Koidz (PAMK) against injury induced by various causes, its potential in alleviating NAFLD remains unknown. This study aimed to investigate PAMK improving and regulatory on gene transcription during process. The results indicated that Highfatdiet (HFD) could induce mice, was found...
Endoplasmic reticulum (ER) stress and oxidative are involved in different types of induced injuries.
The p75 neurotrophin receptor (p75NTR), a member of tumor necrosis factor superfamily, involves in neuronal apoptosis after intracerebral hemorrhage (ICH). It has been previously demonstrated that phosphorylation p35 is crucial for fighting against the proapoptotic p25/CDK5 signaling apoptosis. Then, ICH models rats and primary cortical neurons, we found expressions p75NTR, p-histone H1 (the kinase activity CDK5), p25, Fas-associated phosphatase-1 (FAP-1), phosphorylated myocyte enhancer 2D...
Polysaccharide of Atractylodes macrocephala Koidz (PAMK) is a biologically active component macrocephala, which has the effect maintaining immune homeostasis body. Therefore, this study constructed model PAMK to relieve LPS-induced gosling enteritis and observed morphological changes small intestine after HE staining. ELISA was used detect serum CRP, IL-1β, IL-6, TNF-α levels; immunohistochemistry positive rate IgA in intestine; TLR4, occludin, ZO-1, cytokines, immunoglobulin mRNA expression...