A5049649863- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Health Systems, Economic Evaluations, Quality of Life
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Signaling Pathways in Disease
- Frailty in Older Adults
- Protein Degradation and Inhibitors
- Radiation Dose and Imaging
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Advances in Oncology and Radiotherapy
- Nutrition and Health in Aging
- Pesticide Exposure and Toxicity
- Cancer Cells and Metastasis
- Natural product bioactivities and synthesis
University of South China
2024
Nanchang University
2020-2023
Second Affiliated Hospital of Nanchang University
2020-2022
Zhongkai University of Agriculture and Engineering
2018-2021
Key Laboratory of Guangdong Province
2018-2019
Polysaccharide of Atractylodes macrocephala Koidz (PAMK) has been well recognized as an immune enhancer that can promote lymphocyte proliferation and activate cells. The purpose this study was to evaluate the effects PAMK on humoral cellular functions in immunosuppressed geese. Geese Control group were provided with normal feed, 400 mg·(kg body weight)−1 PAMK, cyclophosphamide (CTX) injected 40 cyclophosphamide, while CTX+PAMK received combination CTX. Spleen development percentages...
As the dominant component of tumor microenvironment, cancer-associated fibroblasts (CAFs), play a vital role in progression. An increasing number studies have confirmed that CAFs are involved almost every aspect tumors including tumorigenesis, metabolism, invasion, metastasis and drug resistance, provide an attractive therapeutic target. This study aimed to explore feature genes for potential targets reliable prediction prognosis patients with gastric cancer (GC). Bioinformatic analysis was...
Polysaccharide of Atractylodes macrocephala Koidz (PAMK) has been reported to have beneficial effects on regulation immune responses in mammals and poultry. Nonetheless, the immunoregulatory mechanism action PAMK remains unclear. The Toll-like receptor 4 (TLR4) signaling cascade proved as a classic polysaccharide-regulated pathway. aim this study was explore TLR4 pathway spleen function mice. Ninety-six 5-week-old BALB/c female mice were randomly allocated into four groups with three...
Lung cancer is a common kind of human malignancies. squamous cell carcinoma (LUSC) key subtype lung cancer. Cell cycle plays an important role in the development and occurrence LUSC, however, there still lack cycle-related genes LUSC diagnosis prediction prognosis.We identified differentially expressed (DEGs) with "limma" package R software, determined biomarkers diagnosing by performing receiver operating characteristic (ROC) curve analysis, biomarker effectiveness was assessed five-fold...
Abstract Background Hepatocellular carcinoma (HCC) is a cancer with poor prognosis. Many recent studies have suggested that pyroptosis important in tumour progression. However, the role of pyroptosis-related genes (PRGs) HCC remains unclear. Materials and methods We identified differentially expressed PRGs tumours versus normal tissues. Through univariate, LASSO, multivariate Cox regression analyses, prognostic PRG signature was established. The effectiveness evaluated by time-dependent...
Background: Diffuse glioma is the most common primary tumor of central nervous system and has a poor prognosis. Recently, new type programmed cell death (PCD), pyroptosis, been found to be widely involved in process diseases. However, expression pyroptosis-related genes (PRGs) diffuse gliomas their relationship with prognosis have rarely evaluated. Methods: In this study, we obtained RNA sequencing clinical data from Cancer Genome Atlas (TCGA) database Chinese Glioma (CGGA) patients....
BACKGROUND:Splenic artery steal syndrome (SASS) can aggravate liver damage in patients with cirrhosis. This study explored whether SASS could be an effective therapeutic target for improving hepatic perfusion and function decompensated MATERIAL AND METHODS:Based on inclusion exclusion criteria, 87 hepatitis B cirrhosis portal hypertension hypersplenism admitted to our General Surgery Department splenectomy pericardial devascularization surgery were selected. A total of 35 cases met the...
The polysaccharide of Atractylodes macrocephala koidz (PAMK) has been proved to have antioxidant, anti-inflammatory, antiviral, and immunity promoting effects. MicroRNAs (miRNAs) also shown participate in the regulation immune function by negatively regulating expression target genes. However, little is known about how PAMK alleviates immunosuppression via miRNA pathway geese. aim this study evaluate influence on immunosuppression. Magang geese (1 day old, n = 200) were randomly divided into...
Abstract Background Gastric cancer (GC) is a primary reason for death in the world. At present, GC has become public health issue urgently to be solved to. Prediction of prognosis critical development clinical treatment regimens. This work aimed construct stable gene set guiding diagnosis and clinic. Methods A microarray dataset TCGA providing information was obtained. Dimensionality reduction carried out by selection operator regression on prognostic genes discovered through bootstrap...
Background: As a powerful tool, single-cell RNA sequencing (ScRNA-seq) can identify the unique cell type and unmask cellular heterogeneity. In present study, we focused on its potential clinical application value for prognostic prediction of multiple myeloma (MM). Methods: ScRNA-seq expression profiling 3,656 MM specimens with therapeutic information was downloaded from GSE117156 via Tumor Immune Single-cell Hub (TISCH). The bulk data patients were GSE9782 GSE24080 Gene Expression Omnibus...
Abstract Background Although the outcome of breast cancer patients has been improved by advances in early detection, diagnosis and treatment, prognostic assessment still faces challenges due to heterogeneity disease. The accumulated data indicate that there is a clear correlation between tumor immune microenvironment clinical outcomes. Methods We screened immune-relevant gene pairs (IRGPs) via univariate Cox regression analysis Cancer Genome Atlas (TCGA) cohort. Then, TCGA cohort were...
Abstract Background Although the outcome of breast cancer patients has been improved by advances in early detection, diagnosis and treatment. Due to heterogeneity disease, prognostic assessment still faces challenges. The accumulated data indicate that there is a clear correlation between tumor immune microenvironment clinical outcomes. Objective Construct immune-related gene pairs evaluate prognosis patient survival rate. Methods From Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO)...
Abstract Background Gastric cancer is one of the leading causes cancer-related death worldwide. How to eliminate gastric an urgent public health problem. Prediction prognosis critical development clinical treatment regimens. The aim this study was establish a stable prognostic gene set guide diagnosis and cancer. Methods A microarray dataset TCGA providing information obtained. selection operator regression method used reduce dimensionality genes identified via bootstrap survival analysis....