A5050496181- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Microbial Natural Products and Biosynthesis
- Ovarian cancer diagnosis and treatment
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer, Hypoxia, and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Toxoplasma gondii Research Studies
- Liver physiology and pathology
- Computational Drug Discovery Methods
- Plant biochemistry and biosynthesis
- RNA modifications and cancer
- Fungal Plant Pathogen Control
- Eicosanoids and Hypertension Pharmacology
- Ferroptosis and cancer prognosis
- Essential Oils and Antimicrobial Activity
- Immune Response and Inflammation
- Ginseng Biological Effects and Applications
- NF-κB Signaling Pathways
- Medicinal plant effects and applications
- Immunotherapy and Immune Responses
Peking University
2020-2025
Peking University Third Hospital
2021-2025
Yanbian University
2019-2024
Qiqihar Medical University
2012-2023
Capital Medical University
1996-2022
Beijing YouAn Hospital
2016-2022
Northwest Minzu University
2020
Hubei University of Medicine
2018-2020
Jinling Institute of Technology
2019
Nanjing General Hospital of Nanjing Military Command
2018-2019
Methamphetamine (METH) abuse causes serious health problems worldwide, and long-term use of METH disrupts the blood-brain barrier (BBB). Herein, we explored potential mechanism endoplasmic reticulum (ER) stress in METH-induced BBB endothelial cell damage vitro therapeutic inhibitors for disruption C57BL/6J mice. Exposure immortalized BMVEC (bEnd.3) cells to significantly decreased viability, induced apoptosis, diminished tightness monolayers. activated ER sensor proteins, including PERK,...
Ischemic stroke is a brain dysfunction disease caused by vascular obstruction. The expression of many kinds microRNAs (miRNAs) related to ischemic stroke. MiRNA has the ability reduce or save injury. Therefore, we aimed explore protective miRNA in ischemia-reperfusion process.The Gene Expression Omnibus (GEO) peripheral RNA sequencing (RNA-seq) datasets patients were analyzed search for differentially expressed miRNAs process. level 60 with and 23 age-matched healthy control inpatients was...
IL-35 has recently been demonstrated to play significant roles in the progression of various malignant tumors. We investigated expression hepatocellular carcinoma (HCC) and regulatory mechanisms HCC progression. Tissue microarray from 75 patients revealed that was primarily localized cytoplasm cancer cells peri-tumoral hepatocytes. Quantitative analysis showed significantly lower advanced stages than early stages. Significantly also observed with higher histological grades, larger tumor...
Arctium lappa L. is a prevalent medicinal herb and health supplement that commonly used in Asia. Over the last few decades, bioactive component arctigenin has attracted attention of researchers because its anti-inflammatory, antioxidant, immunomodulatory, multiple sclerosis fighting, antitumor, anti-leukemia properties. After summarising research literature on arctigenin, this study outlines current status pharmacological activity, total synthesis, structural modification arctigenin. The...
Intrauterine adhesions (IUAs) represent one of the most common diseases in women reproductive age. Patients with moderate‑to‑severe IUA can experience a decrease normal menstrual patterns, amenorrhea and even infertility. At present, first‑line treatment strategies for IUAs clinical practice are hysteroscopic transuterine resection adhesion postoperative adjuvant therapy, including oestrogen. However, high recurrence rate remains. In recent years, studies have demonstrated that aspirin...
Endometrial cancer (EC) is an immunogenic tumor, with CD8+ T cells playing a pivotal role in antitumor immunity. Overexpression of PD1 suppresses cell function by inhibiting CD28, critical co-stimulatory molecule. Classifying based on and CD28 expression provides valuable insights into the immune microenvironment EC. Peripheral blood samples from 120 EC patients tumor tissue 81 were analyzed via flow cytometry. categorized according to expression, their associations clinical characteristics...
Epidemiological studies have strongly linked postmenopausal estrogens uptake with a reduced risk of developing Parkinson's disease (PD) in women. Estrogen replacement therapy may be beneficial early PD. The aim this study is to evaluate the hypothesis that neuroprotective effects phytoestrogen β-ecdysterone (β-Ecd) might mainly result from its antioxidant capability by activation phosphoinositide-3-kinase (PI3K)-nuclear factor E2-related 2 (Nrf2)-regulated signaling pathway. We found β-Ecd...
Abstract Medicinal plants show important therapeutic value in chronic disease treatment. However, due to their diverse ingredients and complex biological effects, the molecular mechanisms of medicinal are yet be explored. By means several high-throughput platforms, here we hawk tea extract (HTE) inhibits Niemann–Pick C1-like 1 (NPC1L1)-mediated free cholesterol uptake, thereby inducing transcription low-density lipoprotein receptor ( LDLR ) downstream sterol response element binding protein...
Six series of (+)-usnic acid derivatives were synthesized. The IC50 values these compounds determined in T. gondii infected HeLa cells (μM) and (μM), their selectivity indexes (SI) calculated. In vitro, most the tested this study exhibited more anti activity than that parent compound positive control drugs. Among derivatives, methyl (E)-(1-(6-acetyl-7,9-dihydroxy-8,9b-dimethyl-1,3-dioxo-3,9b-dihydrodibenzo[b,d]furan-2(1H)-ylidene)ethyl)phenylalaninate (D3) showed effective anti-T....
Lung cancer is a common kind of human malignancies. squamous cell carcinoma (LUSC) key subtype lung cancer. Cell cycle plays an important role in the development and occurrence LUSC, however, there still lack cycle-related genes LUSC diagnosis prediction prognosis.We identified differentially expressed (DEGs) with "limma" package R software, determined biomarkers diagnosing by performing receiver operating characteristic (ROC) curve analysis, biomarker effectiveness was assessed five-fold...