A5047188070- Neurobiology and Insect Physiology Research
- Insect Resistance and Genetics
- Immune Cell Function and Interaction
- Antimicrobial Peptides and Activities
- Sirtuins and Resveratrol in Medicine
- Immune Response and Inflammation
- interferon and immune responses
- Parkinson's Disease Mechanisms and Treatments
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- HIV Research and Treatment
- Biochemical and Structural Characterization
- NF-κB Signaling Pathways
- Gut microbiota and health
- MicroRNA in disease regulation
- Insect and Pesticide Research
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Protein Hydrolysis and Bioactive Peptides
- Clinical Nutrition and Gastroenterology
- Dysphagia Assessment and Management
- Venomous Animal Envenomation and Studies
- Insect Utilization and Effects
- Invertebrate Immune Response Mechanisms
Hubei University of Medicine
2016-2025
First Affiliated Hospital Zhejiang University
2023-2025
Jiangyin People's Hospital
2025
Diabetes Australia
2024
Hypertension Institute
2024
Seoul National University Hospital
2024
Nanjing University of Chinese Medicine
2021-2024
Xiang Yang No.1 People's Hospital
2017-2024
Taihe Hospital
2024
Imperial College London
2024
Recent studies have demonstrated that microalga has been widely regarded as one of the most promising raw materials biofuels. However, lack an economical, efficient and convenient method to harvest microalgae is a bottleneck boost their full-scale application. Many methods harvesting microalgae, including mechanical, electrical, biological chemical based, studied overcome this hurdle.A new flocculation induced by decreasing pH value growth medium was developed for freshwater microalgae. The...
Hsa-miRNA-139-5p (miR-139-5p) has recently been discovered having anticancer efficacy in different organs. However, the role of miR-139-5p on lung cancer is still ambiguous. In this study, we investigated development cancer. Results indicated was significantly down-regulated primary tumor tissues and very low levels were found a non-small cell (NSCLC) lines. Ectopic expression NSCLC lines suppressed growth through inhibition cyclin D1 up-regulation p57(Kip2). addition, induced apoptosis, as...
IntroductionIncreasing evidence shows that gut microbiota dysbiosis may play important roles in the occurrence and progression of Parkinson's disease (PD), but findings are inconsistent. Besides, effect family environment on remains unclear.MethodsWe characterized microbial compositions 63 PD patients, healthy spouses (HS) 74 people (HP) using 16S rRNA sequencing. Clinical phenotypes composition were analyzed comprehensively.ResultsThere markedly different among PD, HS HP samples by...
Reactive oxygen species (ROS) produced in the ischemic myocardium can induce cardiomyocyte injury and death, resulting cardiac remodeling. Ferroptosis, known as a newly type of cell death caused by iron-dependent oxidative stress, which is an essential mechanism cardiomyocytes. However, it unclear whether stress products further ferroptosis aggravate injury. Geniposide (GEN), major active component Gardenia jasminoides J. Ellis , possesses natural antioxidant activity cardioprotective...
Resveratrol is a representative polyphenol of diet‑derived putative cancer chemopreventive agents, which have attracted increasing interest in the chemoprevention community. The inhibition action human papillomavirus (HPV) E6 and E7 has been considered key approach for cervical therapy. shown to induce apoptosis, reduce both viability mitotic index number cell lines, including cells. In present study, it was confirmed that resveratrol inhibited HPV mRNA, protein phosphorylated retinoblastoma...
Abstract Methuselah ( M th) is associated with lifespan, stress resistance and reproduction in D rosophila melanogaster , but Mth not present nondrosophiline insects. A number of methuselah‐likes mthls ) have been identified insects, it unknown whether the functions mth are shared by or divergent from them. Five T ribolium castaneum . Although they different developmental expression patterns, all enhance to starvation. Only mthl1 mthl2 high temperature, whereas mthl4 mthl5 negatively...
Inflammatory cytokines belonging to high mobility group box (HMGB)1 play a key role in sepsis through yet unknown mechanisms. The inflammatory response is modulated by microRNAs (miRNAs or miRs) at multiple levels and poorly understood. In this study, the regulation of HMGB1 miRNAs was evaluated using 3-(2,4-dimethoxybenzylidene)anabaseine (GTS-21) activate cholinergic anti-inflammatory pathway (CAP) decrease expression RAW264.7 cells. Microarray-based miRNA profiling cells used screen...
Aberrant signal transducer and activator of transcription 3 (STAT3) signaling promotes the initiation progression cancer in humans by either inhibiting apoptosis or inducing cell proliferation, angiogenesis, invasion, metastasis. The role resveratrol（RES）in STAT3 pathway vivo, particularly cervical is still unknown. This study aims to investigate its phosphorylation RES-mediated suppression cancer. effects RES on were determined examining tumor tissues, their histological changes, volume...
Innate immunity is an essential way for host cells to resist viral infection through the production of interferons (IFNs) and proinflammatory cytokines. Interferon regulatory factor 3 (IRF3) plays a critical role in innate immune response infection. However, IRF1 remains largely unknown. In this study, we found that upregulated IFN/JAK/STAT signaling pathway upon The silencing attenuates interacts with IRF3 augments activation by blocking interaction between protein phosphatase 2A (PP2A)....
In the postgenomics era, comparative genomics have advanced understanding of evolutionary processes neuropeptidergic signaling systems. The origin many systems can be traced date back to early metazoan evolution based on conserved sequences. Insect parathyroid hormone receptor (iPTHR) was previously described as an ortholog vertebrate PTHR that has a well-known function in controlling bone remodeling. However, there no sequence homologous PTH insect genomes, leaving iPTHR orphan receptor....
Gastrointestinal dysfunction plays an important role in the occurrence and development of Parkinson’s disease (PD). This study investigates composition gut microbiome using shotgun metagenomic sequencing PD patients central China. Fecal samples from 39 (PD group) corresponding healthy spouses (SP) were collected for metagenomics sequencing. Results showed a significantly altered microbial patients. Bilophila wadsworthia enrichment was found patients, which has not been reported previous...
Parkinson's disease is a neurological disorder characterized by motor and gastrointestinal dysfunctions. Resveratrol HP-B-CD inclusion complex improved dysfunction pathological progression of A53T mice through the microbiota-gut-brain axis.
Abstract Background Mammary carcinoma, a pervasive and potentially lethal affliction, is conjectured to be profoundly influenced by physical exercise, both in prophylaxis therapeutic contexts. This study endeavors explore the repercussions of exercise training on progression mammary particularly mechanisms which amalgamation an regimen doxorubicin induces tumor cell apoptosis. Methods Female BALB/c mice were categorized into four distinct groups: A sedentary group (SED), (Ex), (Dox, 5...
Intrauterine adhesions (IUAs) represent one of the most common diseases in women reproductive age. Patients with moderate‑to‑severe IUA can experience a decrease normal menstrual patterns, amenorrhea and even infertility. At present, first‑line treatment strategies for IUAs clinical practice are hysteroscopic transuterine resection adhesion postoperative adjuvant therapy, including oestrogen. However, high recurrence rate remains. In recent years, studies have demonstrated that aspirin...
Trans -resveratrol (RES) exhibits a wide range of biological activities. Various methodological approaches have been established to improve the pharmacokinetic properties RES. Moreover, additional in vivo studies are required support clinical application. In this study, RES/HP-β-CD (RHSD) inclusion complex was prepared and characterized by FTIR, PXRD, DSC NMR data. The effect potential mechanism RHSD against cervical cancer were investigated mouse xenograft tumor model qPCR assay, Western...