A5024925677- Peptidase Inhibition and Analysis
- Sirtuins and Resveratrol in Medicine
- Exercise and Physiological Responses
- Parkinson's Disease Mechanisms and Treatments
- Protein Degradation and Inhibitors
- Extracellular vesicles in disease
- Cancer survivorship and care
- Mitochondrial Function and Pathology
- Phytochemicals and Medicinal Plants
- Medicinal Plants and Neuroprotection
- RNA Interference and Gene Delivery
- Lymphatic System and Diseases
- Biochemical Analysis and Sensing Techniques
- Asthma and respiratory diseases
- Autism Spectrum Disorder Research
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Receptor Mechanisms and Effects
- Signaling Pathways in Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- RNA regulation and disease
- Air Quality and Health Impacts
- Noise Effects and Management
- Ubiquitin and proteasome pathways
Hubei University of Medicine
2022-2025
Xiang Yang No.1 People's Hospital
2023
Parkinson's disease is a neurological disorder characterized by motor and gastrointestinal dysfunctions. Resveratrol HP-B-CD inclusion complex improved dysfunction pathological progression of A53T mice through the microbiota-gut-brain axis.
Abstract Background Mammary carcinoma, a pervasive and potentially lethal affliction, is conjectured to be profoundly influenced by physical exercise, both in prophylaxis therapeutic contexts. This study endeavors explore the repercussions of exercise training on progression mammary particularly mechanisms which amalgamation an regimen doxorubicin induces tumor cell apoptosis. Methods Female BALB/c mice were categorized into four distinct groups: A sedentary group (SED), (Ex), (Dox, 5...
1. Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008. Allergy. 2008;63(Suppl 86):8-160. doi:10.1111/j.1398-9995.2007.01620.x CrossRef Google Scholar
We compared ultracentrifugation, sucrose gradient centrifugation, improved and polyethylene glycol (PEG) precipitation in the extraction of plasma exosomes from human umbilical cord blood, aiming at screening out a stable efficient method. The morphology, structure, size were observed based on transmission electron microscopy dynamic light scattering. Total protein content was determined by bicinchoninic acid (BCA) assay, expression exosome markers CD63 HSP70 negative marker GM130 (Golgi...
Abstract Background: Physical exercise is believed to play a vital role in the prevention and treatment of cancer its complications. However, molecular mechanisms underlying this effect remain unclear. Methods: BALB/c female mice (n=24) were randomly divided into sedentary group (SED), (Ex), Doxorubicin (Dox, 5 mg/kg), + (Dox Ex) after 7 days 4T1 cell implantation. Exercise training lasted for 28 included rotarod experiments resistance training. H&E staining was used observe...
Abstract Background Parkinson's disease (PD) is a neurological disorder characterized by motor and gastrointestinal dysfunctions. There significant need for more effective treatment options. Resveratrol (RES) potent antioxidant anti-inflammatory phytoalexin known its health-promoting benefits. However, little about potential in treating PD modulating the microbial gut-brain axis, clinical application has been limited due to poor water solubility, rapid metabolism, systemic bioavailability....
JQ1, a BRD4 protein inhibitor, first identified because of its therapeutic role in cancer, has gradually demonstrated protective effect on the heart recent years; however, it is unclear whether JQ1 also plays LPS-induced cardiac dysfunction. This paper aims to investigate effects inhibitor dysfunction and mechanism. In experiments, we found that was significantly upregulated hearts LPS-treated mice.JQ1 treatment improved survival function mice reduced cardiomyopathologic injury,...
Abstract JQ1, a BRD4 protein inhibitor, first identified because of its therapeutic role in cancer, has gradually demonstrated protective effect on the heart recent years; however, it is unclear whether JQ1 also plays LPS-induced cardiac dysfunction. This paper aims to investigate effects inhibitor dysfunction and mechanism. In experiments, we found that was significantly upregulated hearts LPS-treated mice.JQ1 treatment improved survival function mice reduced cardiomyopathologic injury,...