A5027966461- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Plant Virus Research Studies
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Liver Disease and Transplantation
- Medicinal Plant Pharmacodynamics Research
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Probiotics and Fermented Foods
- Virus-based gene therapy research
- Viral Infections and Vectors
- interferon and immune responses
- Animal Disease Management and Epidemiology
- Liver Disease Diagnosis and Treatment
- Barrier Structure and Function Studies
- Respiratory viral infections research
Sichuan Agricultural University
2022-2024
Zhongkai University of Agriculture and Engineering
2020-2021
Key Laboratory of Guangdong Province
2021
The polysaccharide of Atractylodes macrocephala Koidz (PAMK) is recognized as an immune enhancer, with anti-cancer, anti-tumour, lymphocyte-activating and lymphocytes proliferation-inducing effects. For investigating the mechanism that PAMK alleviates decline in T cell activation induced by CTX, 24 6-week-old BALB/c female mice were randomly divided into four groups (C, PAMK, + CTX). spleen index, splenocytes morphology death, cytokine concentration, activating factors (CD25, CD69, CD71),...
Polysaccharide Of Atractylodes Macrocephala Koidz (PAMK) has been proved to have anti-cancer, antitumor, anti-inflammation function and improve the immune level of organism. The miRNA plays a very important role in regulating by negatively regulate expression target genes. To explore molecular mechanism PAMK active lymphocytes, thirty 61-d-old geese were randomly divided into 4 groups (C, CTX, PAMK, PAMK+CTX). thymus morphology, serum granulocyte-macrophage colony-stimulating factor...
Although vaccines play a major role in the prevention of infectious bronchitis (IB), Anti-IB drugs still have great potential poultry production. Radix Isatidis polysaccharide (RIP) is crude extract Banlangen with antioxidant, antibacterial, antiviral, and multiple immunomodulatory functions. The aim this study was to explore innate immune mechanisms responsible for RIP-mediated alleviation virus (IBV)-induced kidney lesions chickens. Specific-pathogen-free (SPF) chicken embryo (CEK) cells...
Polysaccharide of Atractylodes macrocephala Koidz (PAMK) is a biologically active component macrocephala, which has the effect maintaining immune homeostasis body. Therefore, this study constructed model PAMK to relieve LPS-induced gosling enteritis and observed morphological changes small intestine after HE staining. ELISA was used detect serum CRP, IL-1β, IL-6, TNF-α levels; immunohistochemistry positive rate IgA in intestine; TLR4, occludin, ZO-1, cytokines, immunoglobulin mRNA expression...
The S2 subunit of infectious bronchitis virus (IBV) plays a critical role in the process IBV infection. A comparison between sequence chicken embryo kidney cell (CEK) adapted virulent QX-like strain SczyC30 (hereafter referred to as zy30) and its CEK-attenuated strain, SczyC100, revealed an N1038S substitution 1154EQTRPKKSV1162 residue deletion C-terminus subunit. In order explore whether these two mutations are related changes biological characteristics IBV, we firstly constructed clone...
The S2 subunit serves a crucial role in infectious bronchitis virus (IBV) infection, particularly facilitating membrane fusion. Using reverse genetic techniques, mutant strains of the locus exhibited substantially different syncytium-forming abilities chick embryonic kidney cells. To determine precise formation mechanism syncytium, we demonstrated co-ordinated Abl2 and its mediated cytoskeletal regulatory pathway within subunit. combination fluorescence quantification, RNA silencing, protein...
The H6N2 subtype avian influenza virus (AIV) is commonly detected in the migratory waterfowl reservoirs. Previously, AIV was believed to be nonpathogenic young chickens and could not infect or shed their respiratory tract under experimental conditions. However, present study, a highly recombinant strain of duck-derived discovered isolated for pathogenicity tests. results revealed that induce seroconversion high morbidity over 86.7%, along with evident upper hemorrhage. Moreover, 5...