A5102775129- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Sirtuins and Resveratrol in Medicine
- Medicinal Plants and Bioactive Compounds
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Antioxidant Activity and Oxidative Stress
- Plant-derived Lignans Synthesis and Bioactivity
- Lipid metabolism and disorders
- Hippo pathway signaling and YAP/TAZ
- Traditional Chinese Medicine Analysis
Shandong University of Traditional Chinese Medicine
2024-2025
Guangzhou Medical University
2023-2024
Abstract Chronic obstructive pulmonary disease (COPD) is a serious chronic lung disease. Schisandrin A (SchA) one of the most important active ingredients in Schisandra chinensis and has been used to treat various diseases several countries. Here, we studied pharmacological effect SchA on airway inflammation induced by cigarette smoke (CS) explored therapeutic mechanism COPD model mice. Our results showed that treatment significantly improved function CS-induced mice reduced recruitment...
Background and Purpose Mitochondrial dysregulation of endothelial progenitor cells (EPCs) has been implicated in destruction hypertension. Regulation silent information regulator 3 (sirtuin 3; SIRT3) mitochondrial damage EPCs the underlying molecular mechanisms remain unclear, evidence selective SIRT3 agonists for treatment hypertension also is lacking. Experimental Approach Here, we discovered a potent agonist, rhynchophylline (Rhy), explored its action on dysfunction. Key Results In...
Abstract Objective Quanzhen Yiqi decoction (QZYQ) is a traditional Chinese medicine for treating chronic obstructive pulmonary disease. Methods Mice were exposed to cigarette smoke (CS) 6 days/week (40 cigarettes/day) 24 weeks and then intragastrically administered QZYQ (4.72, 9.45, or 18.89 g/kg) dexamethasone (DEX, 0.6 mg/kg) weeks. We examined the lung function collected bronchoalveolar lavage fluid inflammatory cell cytokine quantification. The pathological changes, ROS oxidative...