A5086824048- Liver Disease Diagnosis and Treatment
- Heart Failure Treatment and Management
- Nutritional Studies and Diet
- Body Composition Measurement Techniques
- Chronic Kidney Disease and Diabetes
- Neuroinflammation and Neurodegeneration Mechanisms
- Sirtuins and Resveratrol in Medicine
- Cardiovascular Function and Risk Factors
- Microbial Metabolic Engineering and Bioproduction
- Alzheimer's disease research and treatments
- Nutrition and Health in Aging
- Effects and risks of endocrine disrupting chemicals
- Metabolomics and Mass Spectrometry Studies
- Autophagy in Disease and Therapy
- Health, Environment, Cognitive Aging
- Medicinal Plants and Bioactive Compounds
- Blood Pressure and Hypertension Studies
- Cholinesterase and Neurodegenerative Diseases
- Cancer, Lipids, and Metabolism
- Thyroid Disorders and Treatments
- Vitamin D Research Studies
- Antioxidant Activity and Oxidative Stress
- Enzyme Catalysis and Immobilization
- Biochemical and biochemical processes
- Dialysis and Renal Disease Management
Women's Hospital
2025
Nanjing Medical University
2019-2025
Nankai University
2024-2025
Jiangnan University
2025
China University of Geosciences
2025
Chinese Academy of Sciences
2025
Institute of Hydrobiology
2025
South China Agricultural University
2024
Guangzhou University of Chinese Medicine
2014-2024
Shanghai Changzheng Hospital
2024
Abstract Epidemiological studies have found that diabetes and cognitive dysfunction are closely related. Quercetin has been certified with the effect on improving mellitus (DM) impairment. However, related mechanism of quercetin diabetic encephalopathy (DE) still ambiguous. In this study, we used db/db mice (diabetic model) to discover whether could improve DE through Sirtuin1/NLRP3 (NOD‐, LRR‐ pyrin domain‐containing 3) pathway. Behavioural results (Morris water maze new object recognition...
Alzheimer’s disease (AD) is the most common neurodegenerative disease. The accumulation of amyloid beta (A β ) main pathology AD. Metformin, a well-known antidiabetic drug, has been reported to have AD-protective effect. However, mechanism still unclear. In this study, we tried figure out whether metformin could activate insulin-degrading enzyme (IDE) ameliorate A -induced pathology. Morris water maze and Y-maze results indicated that improve learning memory ability in APP swe /PS1 dE9...
The nonlinear associations of serum perfluoroalkyl acids (PFAAs) with hypertension and blood pressure have not been addressed. Cross-sectional data from 6967 adults (age ≥ 20 years) the 2003-2012 National Health Nutrition Examination Survey (NHANES) were analyzed. Hypertension was defined as an average systolic above 140 mmHg, diastolic 90 mmHg or self-reported use prescribed medicine for diagnosed hypertension. After multivariable adjustment, compared lowest tertile, odds ratios (ORs) 95%...
Background: Antioxidant micronutrients represent an important therapeutic option for the treatment of oxidative stress-associated cardiovascular diseases (CVDs). However, few studies have evaluated relationship between levels multiple dietary antioxidants and CVDs. Objective: The study therefore aimed to evaluate associations total specific CVDs among a nationally representative sample adults in US. Design: In total, 39,757 (>20 years) were included this cross-sectional from 2005-2018...
Understanding the complex biological process of aging is great value, especially as it can help develop therapeutics to prolong healthy life. Predicting age from gene expression data has shown be an effective means quantify a subject, and identify molecular cellular biomarkers aging. A typical approach for estimating age, adopted by almost all existing clocks, train machine learning models only on subjects, but infer both unhealthy subjects. However, inherent bias in this results inaccurate...
Selective ablation of tumor cells allows safe eradication, thereby minimizing off‐target damage, while specifically inducing immunogenic cell death (ICD) rather than commonly non‐immunogenic apoptosis enables activation anti‐tumor immune response against residual cancer cells, including metastatic lesions. Herein, we present a general strategy leveraging novel photothermal agent (PTA) that concomitantly precise killing and immunity. The unique PTA scaffold exhibits unexpected inherent...
Abstract Cervical cancer (CC) is a major health threat to women, with immunotherapies targeting the programmed death receptor 1/programmed ligand 1(PD‐1/PD‐L1) axis showing promise but encountering resistance in significant patient population. This has driven critical quest uncover underlying mechanisms. study uncovers novel metabolic involving nicotinamide adenine dinucleotide (NAD + ) salvage pathway enzyme phosphoribosyltransferase (NAMPT) and deacetylase Sirtuin 1 (SIRT1), which...
Background There is a growing body of evidence indicating that metabolites are associated with an increased risk cardiovascular diseases (CVDs), the underlying causality these associations remains largely unchallenged. Given inherent difficulty in establishing using epidemiological data, we employed technique Mendelian randomization to investigate potential role plasma metabolite factors influencing CVDs. Methods The exposure was based on 1,400 metabolites, and outcomes involved four CVD...
Abstract Introduction Recurrent spontaneous abortion (RSA) is associated with maternal-fetal interface dysfunction, particularly abnormal trophoblast invasion and proliferation. However, our understanding of the cause RSA remains limited. Methods Plasma Trp Kyn levels were measured in two groups using enzyme-linked immunosorbent assay. Immunofluorescence western blot analyses employed to evaluate expression IDO1, VEGFA, proteins epithelial-mesenchymal transition (EMT) villous decidual...
The effect of aldehyde exposure on the cardiovascular system remains unclear. objective this study was to determine whether is associated with prevalence disease (CVD). We analyzed associations between aldehydes and CVD using data from 1962 adult participants in National Health Nutrition Examination Survey (NHANES) 2013 2014. Multivariable logistic regression restricted cubic spline models were used examine association CVD. 10.3%. After adjusting for confounding factors, including age, sex,...
BackgroundThere are strong association between remnant cholesterol (RC)/non-high density lipoprotein (NHDL-C) and increase cardiovascular (CV) risk. The aim of present study was to investigate the target lipid parameters (RC NHDL-C) risk CV mortality in general population.MethodsData set from an open database—National Health Nutrition Examination Surveys (NHANES) 2003–2014 were extracted (n = 14992). Kaplan-Meier, multivariable COX regression, restricted cubic spline (RCS)...
Alzheimer's disease (AD) is a neurodegenerative in humans. The accumulation of amyloid-β (Aβ) plays critical role the pathogenesis AD. Previous studies indicated that Salvianolic acid B (SalB) could ameliorate Aβ-induced memory impairment. However, whether SalB influence generation Aβ unclear. Here, we show (25, 50, or 100 µM) reduces Aβ40 and Aβ42 culture media by decreasing protein expressions BACE1 sAPPβ SH-SY5Y-APPsw cells. Meanwhile, increases levels ADAM10 sAPPα has no impact on APP...
Triggering receptor expressed on myeloid cells-1 (TREM-1) is inducible monocyte/macrophages and neutrophils amplifies the inflammatory response. The aim of this study was to determine whether rheumatoid arthritis synovial fibroblasts (RASF) promote expression TREM-1 in monocytes its potential regulatory mechanism.Synovial fluid paired peripheral blood from (RA) patients were analyzed using flow cytometry. Expression detected after co-culture with RASF, or without pre-treatment toll-like...
The flower of Hibiscus syriacus Linn is a well-known traditional Chinese medicine (TCM) and health food in China, which has been used to treat dysentery, vaginal discharge, hemorrhoids. In this study, five polyphenols (compounds 1–5) fatty acids 6–10) were isolated from the ethanol extract H. syriacus. compounds characterized by spectroscopic techniques. Polyphenols, an important type natural product, have variety biological activities. Here, we employed LPS or H2O2-treated SH-SY5Y cell...
Abstract Background The influence of sarcopenic obesity (SO) on overall survival in older adults with hypertension has not been addressed. aim this study was to investigate the prevalence and mortality predictive value various body composition phenotypes, focusing mainly SO, hypertension. Methods We included 1105 hypertensive patients aged ≥ 60 years from National Health Nutrition Examination Survey 1999–2004. Sarcopenia broadly defined based low lean mass (LLM; as measured by dual-energy...
Carnosine can improve mitochondrial dysfunction in the hippocampus of SAMP8 mice and reduce NLRP3 inflammasome apoptosis by improving dysfunction.