A5100694801- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- MicroRNA in disease regulation
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Gastroesophageal reflux and treatments
- Metastasis and carcinoma case studies
- Hepatitis Viruses Studies and Epidemiology
- Gastrointestinal motility and disorders
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Advanced Glycation End Products research
- Birth, Development, and Health
- Pediatric Pain Management Techniques
- Healthcare and Venom Research
Beijing YouAn Hospital
2003-2025
Capital Medical University
2010-2025
Jiangnan University
2025
Shanghai University
2025
Chengdu University of Traditional Chinese Medicine
2024
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
Memorial Sloan Kettering Cancer Center
2013-2023
Zhejiang University
2010-2023
Kettering University
2023
The Nod-like receptor protein 3 (NLRP3) inflammasome activation not only serves as an intracellular machinery triggering inflammation but also produces uncanonical effects beyond such changing cell metabolism and increasing membrane permeability. present study was designed to test whether this NLRP3 contributes the "two-hit" injury during nonalcoholic steatohepatitis (NASH) it can be a therapeutic target for action of Fufang Zhenzhu Tiaozhi (FTZ), widely used herbal remedy hyperlipidemia...
Abstract Inactivated suppressor of mothers against decapentaplegic homolog (SMAD) 4 significantly affects cancer development in pancreatic ductal adenocarcinoma (PDAC). However, the contribution smad4 loss to drug resistance PDAC is largely undetermined. In present study, we reported that SMAD4 endows cells ability through upregulating histone lysine demethylase, Lysine-Specific Demethylase 5B (KDM5B, also known as JARID1B or PLU1). Upregulated KDM5B was found PDAC, associated with poor...
Background and Aim Acute on chronic liver failure (AoCLF) is associated with a high mortality rate. Plasma exchange (PE) may be useful to bridge patients AoCLF transplantation or regenerate their own livers. The aim of this study was assess the effects PE circulating concentrations cytokines in AoCLF. Methods One hundred forty-nine 2 groups (PE plus routine-care, n=62; n=87) were enrolled our study. Fifteen healthy donors used as control group. Cytokine levels such interferon-γ (IFN-γ),...
BACKGROUNDCirrhosis is a chronic late stage liver disease associated with hepatitis viruses, alcoholism, and metabolic disorders, such as Wilson (WD).There are no clear markers or clinical features that define cirrhosis originating from these disparate origins.We hypothesized not one of different etiology may have differential hepatic features. AIMTo delineate the between WD-associated Bassociated in Chinese population. METHODSIn this observational study, we reviewed medical data consecutive...
Abstract Objective The roles of hippocampal AMPAR s were investigated in irritable bowel syndrome ( IBS )‐like rats to clarify the central sensitization mechanisms. Methods model was induced by neonatal maternal separation. effects on visceral hypersensitivity examined responses abdominal muscle colorectal distension after bilateral intrahippocampal injections CNQX (an inhibitor). expressions (GluR1 and GluR2) determined Western blot. Results ‐like showed when compared with controls....
// Lingfang Teng 1 , Yu Chen Huihui Xijun He Junyou Wang Yujiang Peng Hongyu Duan Huiyong Li Da Lin and Bo Shao Department of Neurosurgery, The First People's Hospital Wenling, Wenling 317500, Zhejiang Province, China Correspondence to: Shao, email: boshaofire@163.com Keywords: circular RNAs (circRNAs); intracranial aneurysms (IA); disease-free survival (DFS); overall (OS); diagnosis Received: July 25, 2017 Accepted: August 28, Published: November 10, ABSTRACT Circular (circRNAs) in the...
ObjectiveTo explore the relation between serum sphingolipids and hepatic injury in chronic HBV infection.MethodsA cohort of participants including 48 healthy persons, 103 HBV-infected patients containing hepatitis B (CHB) HBV-related cirrhosis were included. High performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) was performed detect sphingolipids. The serological indicators detected quantified. valid liver biopsy specimens acquired from twenty five...
Fusion between TMPRSS2 and ERG, placing ERG under the control of promoter, is most frequent genetic alteration in prostate cancer, present 40–50% cases. The fusion event an early, if not initiating, implicating TMPRSS2-positive epithelial cell as cancer origin fusion-positive cancer. To introduce alterations into Tmprss2-positive cells mice a temporal-specific manner, we generated Tmprss2-CreERT2 knock-in mouse. We found robust tamoxifen-dependent Cre activation luminal but basal cells, well...
Optical coherence tomography (OCT) revealed that cells lining proximal convoluted tubules of living donor kidneys (LDKs) procured by laparoscopic procedures were very swollen in response to the brief period ischemia experienced between time arterial vessel clamping and flushing excised kidney with cold preservation solution. Damage as a result this cell swelling resulted varying degrees acute tubular necrosis (ATN) slowed recovery during first 2 weeks after their transplantation.To prevent...
To investigate the clinicopathological and prognostic factors related to early gastric cancer recurrence after curative resection.Between October 2006 August 2018, a total of 149 patients with cancer/adenocarcinoma esophagogastric junction resection were enrolled from our treatment group. A retrospective clinical analysis was performed on these resection.Among patients, 99 (66.4%) had only one pattern, 50 (33.6%) multiple patterns. The median recurrence-free survival (RFS) 18.2 months (95%...
AIM:To investigate the effects of ZD 7288, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, on rats with chronic visceral pain. METHODS:Rats hypersensitivity were generated using neonatal colon irritation during postnatal days 8-15 as described previously.Visceral was evaluated electromyographic (EMG) responses abdominal external oblique muscles to 20-80 mmHg colorectal distentions (CRD).Abdominal withdrawal reflex (AWR) scores and pain thresholds also detected in...
Abstract Although serum bile acids and total cholesterol (TC) are closely related to liver cirrhosis, the potential diagnostic value of acid-to-cholesterol ratio (TBA/TC) for fibrosis is unclear. The present study aimed evaluate TBA/TC in diagnosis cirrhosis relationship between significant chronic hepatitis B virus (HBV) infected patients without cholestasis. 667 with alkaline phosphatase (ALP) ≤ 1.5 upper limit normal (ULN) gamma-glutamyl transferase (GGT) 3 ULN were rigorously included...
Shewanella algae, a Gram-negative bacillus found in warm saltwater environments, has been increasingly recognized as human pathogen that can cause infection of the skin and soft tissue, ear, blood, intra-abdominal. In this case, we report algae caused sepsis, renal insufficiency, cardiac dysfunction, fistula massive pleural effusion after surgery 73-year-old man with cancer esophagus cardia.