A5101782302- Breast Cancer Treatment Studies
- Virus-based gene therapy research
- Cancer Research and Treatments
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Breast Lesions and Carcinomas
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Renal and related cancers
- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Animal Virus Infections Studies
- Pluripotent Stem Cells Research
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2021-2025
Chaohu Hospital of Anhui Medical University
2024
Zhejiang University
2015-2024
Second Affiliated Hospital of Zhejiang University
2017-2024
Second Xiangya Hospital of Central South University
2019-2024
Central South University
2019-2024
Zhejiang Cancer Hospital
2023
Nanfang Hospital
2020-2023
Southern Medical University
2020-2023
Seventh People's Hospital of Dalian
2022
To gain more information on the prevalence of germline mutations in BRCA1/2 and PALB2 genes Chinese population, to explore effects mutation status these clinical outcomes patients with breast cancer, we performed a screening for consecutive series unselected cancer population. A total 2,769 cases were enrolled between June 1993 September 2017. All exons exon–intron boundaries screened next‐generation sequencing. Of patients, BRCA1 , BRCA2 accounted 2.7% (n = 74), 76), 0.9% 24), respectively....
Objective This study aims to elucidate the genetic and phenotypic characteristics of pediatric patients with potential Dent disease (DD).
Background This study reported the function and mechanism of circ-0000512 in progression triple-negative breast cancer (TNBC). Methods expression TNBC tissues paired adjacent normal cells was examined by qRT-PCR. Moreover, modulated transfection. Thereafter, colony formation assay, Transwell assay flow cytometry were conducted to observe cell proliferation, migration apoptosis. treated with cycloheximide protease inhibitor MG132. Later, ubiquitination performed detect programmed death ligand...
Cervical cancer continues to be one of the leading causes deaths among females in low and middle-income countries. In this study, we aimed assess independent prognostic value clinical potential factors progression-free survival (PFS) cervical cancer.We conducted a retrospective study on 92 patients treated from 2017 2019 at Zhuhai Hospital Traditional Chinese Western Medicine. Tumor characteristics, treatment options, follow-up information were collected. Kaplan-Meier method was used...
// Lingfang Teng 1 , Yu Chen Huihui Xijun He Junyou Wang Yujiang Peng Hongyu Duan Huiyong Li Da Lin and Bo Shao Department of Neurosurgery, The First People's Hospital Wenling, Wenling 317500, Zhejiang Province, China Correspondence to: Shao, email: boshaofire@163.com Keywords: circular RNAs (circRNAs); intracranial aneurysms (IA); disease-free survival (DFS); overall (OS); diagnosis Received: July 25, 2017 Accepted: August 28, Published: November 10, ABSTRACT Circular (circRNAs) in the...
Glioblastomas (GBMs) are a lethal class of brain cancer, with median survival <15 months in spite therapeutic advances. The poor prognosis GBM is largely attributed to acquired chemotherapy resistance, and new strategies urgently needed target resistant glioma cells. Here we report role for miR-299-5p GBM. level expression was detected specimens cell lines by qRT-PCR. Luciferase reporter assays Western blots were performed verify GOLPH3 as direct miR-299-5p. In vitro proliferation,...
<h3>Objective:</h3> Circulating tumor cells (CTCs) play a critical role in cancer metastasis, but their prevalence and significance remain unclear. This study attempted to track the epithelial-mesenchymal transition (EMT) status of CTCs breast patients investigate clinical relevance. <h3>Methods:</h3> In this study, established negFACS-IF:E/M platform was applied isolate rare characterize EMT cancer. A total 89 were recruited, including stage 0–III (<i>n</i> = 60) late 29) cases....
UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family that regulates cell survival and apoptosis in ligand-dependent manner. UNC5B plays an important role development multiple cancers, including colorectal, bladder, thyroid cancer. However, exact expression pattern mechanism breast cancer have not been well elucidated. Here, we showed was significantly upregulated using bioinformatics analysis experimental validation. High correlated with poor overall patients. knockdown...
Colorectal cancer (CRC) is a common malignant tumor. Alcohol consumption positively correlated with CRC metastasis; however, the mechanism unclear. The interaction between laminin-γ2 (LAMC2) and integrin-β1 (ITGB1) plays role in premetastatic niche signaling, which may induce epithelial mesenchymal transformation (EMT) lead to metastasis.To investigate effects of alcohol on metastasis from molecular niche.The LAMC2 ITGB1 was measured by Duolink assay, expression levels LAMC2, focal adhesion...
Five RecQ helicase family members have a role in maintaining genome stability. However, their prognostic roles breast cancer remain unknown. We aimed to investigate the values of and clinical outcomes cancer.We used Kaplan-Meier Plotter database (http://kmplot.com/analysis) analyze RecQ-family mRNA expression all cancers different intrinsic subtypes clinicopathological characteristics. Protein-expression levels WRN RECQL4 were confirmed by immunohistochemistry (IHC) tissues.Increased RECQL...
Background: The retrieved lymph node (LN) count has been confirmed as a prognostic indicator in various cancers. However, the correlation between LN counts and patient prognosis gastric cancer with node-positive is not fully studied. Methods: A total of 8475 patients undergoing gastrectomy Surveillance, Epidemiology, End Results Program (SEER)-registered were analyzed. Kaplan-Meier methods multivariable Cox regression models used to analyze long-term outcomes risk factors. Moreover,...
e12622 Background: CDK4/6 inhibitors, in combination with endocrine therapy, have shown efficacy as neoadjuvant treatment HR+/HER2- breast cancer (BC). This study investigates the and safety of dalpiciclib, a inhibitor, combined aromatase inhibitors (AI) for luminal B BC (defined ER+/HER2- BC, either Ki67≥20% and/or PR<20%). Methods: single-arm, single-center, phase II (NCT05640778) enrolled patients aged 18-75 clinical stage I-III primary tumor size ≥2 cm, ECOG PS 0-1. Eligible patients,...
Abstract Background International guidelines recommend cyclin‐dependent kinase 4/6 inhibitor (CDK4/6i)‐based first‐line therapy for hormone receptor‐positive, human epidermal growth factor receptor 2‐negative (HR+/HER2−) advanced breast cancer (ABC). However, direct drug comparisons are lacking. We aimed to identify the most effective and safe through network meta‐analysis (NMA). Methods searched PubMed, Embase, Web of Science, Cochrane Central Register Controlled Trials, OpenGrey up...
Acute myocardial infarction (AMI), which commonly leads to heart failure, is among the leading causes of mortality worldwide. The aim this study was find potential regulatory network for miRNA-inflammation, oxidative stress and prognosis-related mRNA uncover molecular mechanisms AMI.The expression profiles miRNA in blood samples from AMI patients were downloaded Gene Expression Omnibus (GEO) dataset differential analysis. Weighted gene co-expression analysis (WGCNA) used further identify...
Esophageal squamous cell carcinoma (ESCC) is a common cancer in East Asia and other parts of the world exhibits poor prognosis. Growth inhibitor 5 (ING5) new member growth (ING) protein family involved many important cellular functions, such as cycle, apoptosis, chromatin remodeling. As newly discovered tumor suppressor, ING5 has been shown to inhibit lung proliferation distant metastasis through AKT pathway. In tumors, can attenuate ability cells invade normal tumor-adjacent tissues....