A5102958823- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
- RNA modifications and cancer
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Gut microbiota and health
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Potato Plant Research
- Nephrotoxicity and Medicinal Plants
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Breast Lesions and Carcinomas
- Gestational Diabetes Research and Management
- Ginger and Zingiberaceae research
- Wnt/β-catenin signaling in development and cancer
- Prostate Cancer Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Immune cells in cancer
Zhejiang Hospital
2020-2023
Second Affiliated Hospital of Zhejiang University
2017-2020
Ministry of Education of the People's Republic of China
2019
Zhejiang University
2017-2018
Women's Hospital, School of Medicine, Zhejiang University
2017
Ningbo University
2014-2016
Objective Macrophages are among the most abundant cells in colon tumour microenvironment, and there is a close relationship monocytes, macrophages gut microbiota. Alterations microbiota involved development, but underlying mechanisms remain unclear. We aim to elucidate temporal changes macrophage subsets functions, how these dynamics regulated by microbial cues initiation of colitis-associated cancer. Design A mouse model tumourigenesis was established determine dynamics. The role...
Long noncoding RNAs (lncRNAs) play an important role in cancer occurrence and development. However, there is largely unknown about lncRNAs significance the diagnosis treatment of gastric cancer. In our study, we focused on AC130710, one lncRNAs. Gastric tissues adjacent were gathered from 78 patients with The AC130710 levels detected by reverse transcription polymerase chain reaction (RT-PCR). Then, further analyzed association between level clinicopathological factors Finally, molecular...
Long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. However, the diagnostic values of most lncRNAs are largely unknown. To investigate whether gastric juice lncRNA-ABHD11-AS1 can be a potential biomarker screening cancer, 173 tissue samples and 130 from benign lesion, dysplasia, premalignant lesions, cancer were collected. ABHD11-AS1 levels detected by reverse transcription-polymerase chain reaction. Then, relationships between clinicopathological factors patients with...
To gain more information on the prevalence of germline mutations in BRCA1/2 and PALB2 genes Chinese population, to explore effects mutation status these clinical outcomes patients with breast cancer, we performed a screening for consecutive series unselected cancer population. A total 2,769 cases were enrolled between June 1993 September 2017. All exons exon–intron boundaries screened next‐generation sequencing. Of patients, BRCA1 , BRCA2 accounted 2.7% (n = 74), 76), 0.9% 24), respectively....
<h3>Objective:</h3> Circulating tumor cells (CTCs) play a critical role in cancer metastasis, but their prevalence and significance remain unclear. This study attempted to track the epithelial-mesenchymal transition (EMT) status of CTCs breast patients investigate clinical relevance. <h3>Methods:</h3> In this study, established negFACS-IF:E/M platform was applied isolate rare characterize EMT cancer. A total 89 were recruited, including stage 0–III (<i>n</i> = 60) late 29) cases....
Five RecQ helicase family members have a role in maintaining genome stability. However, their prognostic roles breast cancer remain unknown. We aimed to investigate the values of and clinical outcomes cancer.We used Kaplan-Meier Plotter database (http://kmplot.com/analysis) analyze RecQ-family mRNA expression all cancers different intrinsic subtypes clinicopathological characteristics. Protein-expression levels WRN RECQL4 were confirmed by immunohistochemistry (IHC) tissues.Increased RECQL...
To investigate the effect of dietary fiber on blood glucose and pregnancy outcomes in patients with gestational diabetes mellitus (GDM). One hundred twelve GDM second trimester were recruited from Women's Hospital, Zhejiang University School Medicine. Patients randomized into two groups 56 each group: control group received basic nutrition support; while given additional ( total per day) before meals addition to support. Intervention for all cases lasted 8 weeks. Fasting postprandial (2 h...
Nischarin is an integrin‑binding protein, which well known as a novel tumor suppressor. In breast cancer, serves critical role in cancer cell migration and invasion. However, the molecular mechanism underlying of remains unclear. Recent findings have demonstrated that epithelial‑mesenchymal transition (EMT) increases capacity As member integrin family, it was hypothesized may regulate cellular processes via various signaling pathways associated with EMT process. The present study...
1530 Background: PALB2 (Partner and Localizer of BRCA2) is recently recognized as a breast cancer predisposition gene, which plays critical role in genome maintenance via interacting with BRCA1/2 RAD51 when DNA break. Germline loss-of-function mutations lead to increased risk. Since the germline mutation frequency much less than BRCA1/2, distinct spectrum still obscure. Therefore, we assessed mutational frequency, predictors gene sequential series Chinese patients from our Research Bank,...
Purpose: To investigate the potential mechanism by which zerumbone suppresses breast cancer (BC) cells.Methods: Cell viability and Transwell assays were performed to assess effect of on BC cell growth. The downstream target was determined using quantitative polymerase chain reaction immunoblotting. immunoblotting conducted detect if had any BACH1 (BTB domain CNC homolog 1) expression.Results: Zerumbone suppressed proliferation, migration, invasion cells. It also upregulated expression...
Mounting evidence supports a role for DNA methylation in the pathogenesis of leukemia; however, there no overview these results Chinese population. The present study performed comprehensive meta‑analysis to establish candidate genes with an altered status leukemia patients. Eligible studies were identified through searching National Center Biotechnology Information PubMed and Wanfang databases. Studies pooled overall odds ratios corresponding confidence intervals calculated. A total 4,325...