A5020337434- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Angiogenesis and VEGF in Cancer
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- Nanomaterials for catalytic reactions
- Acupuncture Treatment Research Studies
- Signaling Pathways in Disease
- Healthcare and Venom Research
- Ubiquitin and proteasome pathways
- Biochemical Analysis and Sensing Techniques
- Central Venous Catheters and Hemodialysis
- Skin Protection and Aging
- Environmental remediation with nanomaterials
- melanin and skin pigmentation
- Estrogen and related hormone effects
- Acute Myocardial Infarction Research
- Cancer Treatment and Pharmacology
- Acute Kidney Injury Research
- Glycosylation and Glycoproteins Research
- Vascular Malformations Diagnosis and Treatment
Ningbo University
2013-2024
China-Japan Friendship Hospital
2019-2024
Ningbo University Affiliated Hospital
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Abstract Background Long non-coding RNAs (lncRNAs) are prevalently transcribed in the genome yet their potential roles human cancers not well understood. The aim of present study was to determine lncRNA expression profile gastric cancer and its clinical value. Methods global measured by microarray. Levels two representative lncRNAs, H19 uc001lsz, were confirmed real-time reverse transcriptase-polymerase chain reaction. relationship between levels clinicopathological factors patients with...
Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis. However, the mechanisms of most lncRNAs cancers are largely unknown. Because RNA component mitochondrial processing endoribonuclease (RMRP) is one dysregulated gastric cancer, this study explored its molecular carcinogenesis. RMRP levels 792 tissues, plasma and juices from patients with various stages tumorigenesis were analyzed by quantitative reverse transcription-polymerase chain reaction. Overexpression interference used...
BACKGROUND Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. However, the value of lncRNAs diagnosis gastric cancer remains unknown. To identify whether lncRNA‐AA174084 is potential marker for early (GC), authors investigated its levels tissues, blood, and juices from patients with various stage METHODS Total RNA 860 specimens healthy controls was extracted. Levels AA174084 134 paired GC 127 mucosal 335 plasma samples, 130 juice samples at each tumorigenesis were measured...
It has been known that differential expression of long non-coding RNA (lncRNA) plays critical roles in carcinogenesis. However, the significance lncRNA, especially intergenic ncRNA (lincRNA, main type lncRNA family), diagnosis gastric cancer is largely unknown. The aim this study was to determine level LINC00152, a newfound lincRNA, carcinoma and its clinical association. LINC00152 71 pairs tumorous adjacent normal tissues from patients with detected by quantitative real-time reverse...
Long noncoding RNAs (lncRNAs) play an important role in cancer occurrence and development. However, there is largely unknown about lncRNAs significance the diagnosis treatment of gastric cancer. In our study, we focused on AC130710, one lncRNAs. Gastric tissues adjacent were gathered from 78 patients with The AC130710 levels detected by reverse transcription polymerase chain reaction (RT-PCR). Then, further analyzed association between level clinicopathological factors Finally, molecular...
Long noncoding RNAs (lncRNAs) are newfound that greater than 200 nucleotides in length. They have emerged recently as major players governing fundamental biological processes. However, the expression level of lncRNAs and their clinical significances not well understood. To investigate lncRNA gastric cancer, real-time reverse transcriptase-polymerase chain reaction was conducted. Then, association between AC096655.1-002, one lncRNA, cancer tissues clinicopathological features patients with...
Aim: To explore the diagnostic value of hsa_circ_0074362 in screening gastric cancer. Methods: The expression levels 127 cancer tissues and paired adjacent normal tissues, 83 gastritis six cell lines were first detected by quantitative reverse transcription-polymerase chain reaction. Then, relationship between its clinicopathological factors patients with was analyzed. Finally, a receiver operating characteristic curve established. Results: Hsa_circ_0074362 significantly downregulated lines....
Abstract Background In addition to non‐coding RNAs (lncRNAs) and microRNAs (miRNAs), circular (circRNAs) are endogenous with various functions, which have recently become a research hotspot. CircRNAs kind of closed RNA molecule widely existing in transcriptomes. Due lack free ends, they not easily cleaved by RNase R, thus avoiding degradation. They more stable than linear RNAs. Methods Data were collected through PubMed. The following search terms used: “circular RNA,” “circRNA,” “cancer,”...
Long noncoding RNAs (lncRNAs) have been gradually confirmed to be tumor-associated biological molecules in recent years. However, the clinical significances of most lncRNAs screening gastric cancer are largely unknown. Based on our lncRNA array results, this study, we explored potential relationship between HMlincRNA717 expression levels and clinicopathologic factors cancer. A total 313 samples were collected from two centers, then level human tissues cell lines was measured by real-time...
Colorectal cancer (CRC) is a common clinical that remains incurable in most cases. miRNAs are reported to play part the development of various tumors. In present study, we found miR-324-5p was downregulated CRC cells, while ELAV (embryonic lethal, abnormal vision,
Objective: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Small nucleolar RNA host gene 6 (SNHG6) was reported to function as an oncogene in number cancers. Here, we aimed further explore the roles and molecular mechanism SNHG6 CRC metastasis. Methods: The expression levels SNHG6, miR-26a, enhancer zeste homolog 2 (EZH2) mRNA were assessed by quantification real-time PCR tissues cell lines. Western blot analysis performed determine E-cadherin, Snail, Vimentin,...
Abstract An innovative methodology is presented for synthesizing synthetic polymer nanoparticles (TINPs) as potent tyrosinase inhibitors. This inhibition strategy combines the integration of two distinct functionalities, phenol, and phenylboronic acid, within TINPs structure. The phenyl group mimics natural monophenol substrate, forming a strong coordination with catalytic copper ion, significantly inhibiting activity. Additionally, acid interacts catechol, another further reducing enzyme...
Targeted drug delivery could increase the efficacy of chemotherapy, however, a plethora obstacles exist in current targeted designs. In this study, we introduce novel avenue using electro-acupuncture and evaluate its effect on distribution paclitaxel breast cancer mouse model. Our results show that intervention significantly increased intratumoral concentration paclitaxel. The mice acupuncture group showed shorter t max, longer 1/2 higher AUC as compared with paclitaxel-only group. Moreover,...
Objective: This investigation examined the effect of velvet antler (VA) on endothelial progenitor cells (EPCs) and associated effects to promote angiogenesis repair vascular injury in rats with myocardial infarction (MI). Methods: VA was analyzed by liquid chromatography-mass spectrometry. Male Sprague Dawley were randomly divided into four groups: sham, MI, VA, + DAPT (gamma-secretase inhibitor IX, a specific blocker Notch signaling pathway) group. The underwent ligation left anterior...
As the most representative family of proteinases related to tumorigenesis, matrix metalloproteinase-9 (MMP-9) represents a key player in cancer cell migration and regulation tumor microenvironment. The inhibition MMP-9 activity has been pursued as target for anticancer therapy. However, synthetic inhibitors have failed clinical trials because their lack selectivity. Here, an abiotic mimic based on molecularly imprinted nanoparticles designed inhibitor MMP-9. To attain fast mass transfer...