A5048939071- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Circular RNAs in diseases
- Liver Disease and Transplantation
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Hepatitis B Virus Studies
- Catalytic Cross-Coupling Reactions
- Protein purification and stability
- Fibroblast Growth Factor Research
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Molecular Junctions and Nanostructures
- Organoboron and organosilicon chemistry
- Protein Hydrolysis and Bioactive Peptides
- Extracellular vesicles in disease
- Meat and Animal Product Quality
- CRISPR and Genetic Engineering
- Immunotherapy and Immune Responses
- Advanced Nanomaterials in Catalysis
- 14-3-3 protein interactions
Ningbo University
2020-2024
Nanjing University of Posts and Telecommunications
2024
Inserm
2024
Université de franche-comté
2024
Henan University of Science and Technology
2022-2023
Wenzhou University
2015-2022
Soochow University
2022
Ningbo University Affiliated Hospital
2021
Guizhou University
2020
Wenzhou Medical University
2012-2018
Transfer RNA (tRNA)-derived small RNAs (tsRNAs) have been found to play important roles in the occurrence and development of cancers. However, tsRNA profile gastric cancer is unknown. In this study, we aimed identify global plasma from patients elucidate role tRF-33-P4R8YP9LON4VDP cancer. Differentially expressed tsRNAs healthy controls were investigated using sequencing. The expression levels patients, cell lines first detected by quantitative reverse transcription-polymerase chain...
Background and aim: Medicine has made great progress, but gastric cancer is still one of the most common malignant tumors worldwide.tRNA-derived fragments (tRFs), a type small non-coding RNA, have been found to play important roles in cancers.Due an abundance modifications, tRFs potential serve as biomarkers.However, relationship between largely unclear.We identified new tRF, tRF-19-3L7L73JD, be expressed at lower level patients than healthy controls.Our study aims explore diagnostic value...
Lithium-promoted hydroboration of alkynes and alkenes using commercially available hexamethyldisilazane lithium as a precatalyst HBpin hydride source has been developed. This method will be appealing for organic synthesis because its remarkable substrate tolerance good yields. Mechanistic studies revealed that the proceeds through in situ-formed BH3 species, which acts to drive turnover alkenes.
A CRISPR-amplified electrochemical aptasensor was designed for highly sensitive and selective detection of HbA1c in ideal buffer real samples.
Summary At present, there is no ideal model for predicting the short‐term outcome of patients with acute‐on‐chronic hepatitis B liver failure ( ACHBLF ). This study aimed to establish and validate a prognostic by using classification regression tree CART ) analysis. A total 1047 from two separate medical centres suspected were screened in study, which recognized as derivation cohort validation cohort, respectively. analysis was applied predict 3‐month mortality . The accuracy tested area...
The homoleptic lanthanide complex Sm[N(TMS)<sub>2</sub>]<sub>3</sub> is an efficient rare-earth catalyst for the hydroboration of alkynes to corresponding alkenylboron compounds.
(1) Transfer RNA (tRNA)-derived fragments (tRFs) are a new category of regulatory non-coding RNAs with distinct biological functions in cancer. They produced from pre-tRNAs or mature tRNAs and their sequences relatively short; thus, the amplification tRFs, especially those body fluids, is faced certain technical difficulties. In this study, we established quantitative method to detect plasma tRF-27-87R8WP9N1E5 (tRF-27) used it screen gastric cancer patients. (2) A specific...
Accumulated evidence indicates that the intestinal microbiota plays crucial roles in initiation and progression of colorectal cancer (CRC). However, effects tissue-associated on CRC metastasis are poorly defined. The aim this study was to explore differences bacteria between metastatic non-metastatic tissues identify potential bacterial species associate with metastasis. 16S rDNA amplicon high-throughput sequencing used test patients (n = 48) 44). microbial diversity differential were...
Currently, there are no robust models for predicting the outcome of acute-on-chronic hepatitis B liver failure (ACHBLF). We aimed to establish and validate a new prognostic scoring system, named ALPH-Q, that integrates electrocardiography parameters may be used predict short-term mortality patients with ACHBLF. Two hundred fourteen were included in this study. The APLH-Q score was constructed by Cox proportional hazard regression analysis validated an independent patient cohort. area under...
Gastric cancer (GC) is a particularly malignant disease; thus, early diagnosis and treatment are especially important. Transfer RNA-derived small RNAs (tsRNAs) have been implicated in the onset progression of various cancers. Therefore, aim this study was to explore role tRF-18-79MP9P04 (previously named tRF-5026a) GC. Expression levels were quantified gastric mucosa specimens healthy controls plasma samples patients with different stages The results showed that significantly decreased...
// Ming-Hua Zheng 1, 2 , Sheng-Jie Wu 3 Ke-Qing Shi Hua-Dong Yan 4 Hai Li 5 Gui-Qi Zhu 6 Yao-Yao Xie 7 Fa-Ling Yong-Ping Chen 1 Department of Infection and Liver Diseases, Research Center, The First Affiliated Hospital Wenzhou Medical University, 325000, China Institute Hepatology, Cardiovascular Medicine, Heart Infectious Ningbo 315010, Intensive Care Unit, Tianjin Disease Hospital, 300000, School the Clinical Sciences, Laboratory, Correspondence to: Chen, e-mail: 13505777281@163.com...
With the demand for road transport of hazmat in past few years, accidents occur frequently during dangerous goods transportation and safety issues become increasingly prominent. Therefore, it is urgent to make full use technical measures information collection transmission monitor state goods. A real-time system put forward this paper, which can by using Global Positioning System (GPS)/BeiDou Navigation Satellite (BDS) technology sensor acquisition modules, based on RS485 bus technology....
DNA damage and antioxidant activities of sour meat peptides were evaluated using chemiluminescence spectroscopic methods. All exhibited protection free radical scavenging against DPPH radicals, hydroxyl radicals superoxide anions in a dose-dependent manner, showed the strongest inhibition weakest anion radicals. The IC50 values from inoculating fermentation 2.11, 4.23, 0.097 9.85 mg/mL for capacities respectively, significantly lower than those traditional (P < 0.05). Compared to...