A5003662760- Gut microbiota and health
- Mycobacterium research and diagnosis
- Antimicrobial Peptides and Activities
- Inflammation biomarkers and pathways
- Occupational and environmental lung diseases
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- Probiotics and Fermented Foods
- Circular RNAs in diseases
- Immune cells in cancer
- Inflammatory Bowel Disease
- Neurogenetic and Muscular Disorders Research
- Clostridium difficile and Clostridium perfringens research
- Pneumonia and Respiratory Infections
- Phagocytosis and Immune Regulation
- Glutathione Transferases and Polymorphisms
- Amyotrophic Lateral Sclerosis Research
- Gastric Cancer Management and Outcomes
- Neutropenia and Cancer Infections
- Digestive system and related health
Ningbo University
2021-2024
Zhejiang University
2016-2021
First Affiliated Hospital Zhejiang University
2019-2020
Zhejiang Lab
2020
Objective Antimicrobial peptides (AMPs) play essential roles in maintaining gut health and are associated with IBD. This study is to elucidate the effect of angiogenin (ANG), an intestine-secreted AMP, on microbiota its relevance Design The ANG contribution colitis were evaluated different models co-housing faecal transplantation. ANG-regulated bacteria determined by 16S rDNA sequencing their functions analysed bacterial colonisation. species-specific antimicrobial activity underlying...
Metastasis of colorectal cancer (CRC) is the leading cause CRC‐associated mortality. Angiogenin (ANG), a member ribonuclease A superfamily, not only activates endothelial cells to induce tumor angiogenesis, but also targets promote cell survival, proliferation and/or migration. However, its clinical significance and underlying mechanism in CRC metastasis are still largely unknown. Here, we reported that ANG was upregulated tissues associated with patients. We then revealed enhanced growth...
Abstract Silica nanoparticles (SiNPs) have been reported to induce pulmonary fibrosis (PF) with an unknown mechanism. Recently, the activation of autophagy, a lysosome-dependent cell degradation pathway, by SiNPs has identified in alveolar epithelial cells (AECs). However, underlying mechanism and relevance SiNPs-induced autophagy development PF remain elusive. Here, we report that dysfunction subsequent apoptosis AECs are involved PF. engulfed enhance autophagosome accumulation both vivo...
Silica nanoparticles (SiO2 NPs) cause oxidative stress in respiratory system. Meanwhile, human cells launch adaptive responses to overcome SiO2 NP toxicity. However, besides a few examples, the regulation of NP-responsive proteins and their functions response remain largely unknown. In this study, we demonstrated that induced expression follistatin (FST), responsive gene, mouse lung tissue as well epithelial (A549). The levels Ac-H3(K9/18) H3K4me2, two active gene markers, at FST promoter...
Abstract Antimicrobial proteins contribute to host-microbiota interactions and are associated with inflammatory bowel disease (IBD), but our understanding on antimicrobial protein diversity functions remains incomplete. Ribonuclease 4 (Rnase4) is a potential no known function in the intestines. Here we find that RNASE4 expressed intestinal epithelial cells (IEC) including Paneth goblet cells, detectable human mouse stool. Results from Rnase4- deficient mice recombinant suggest Rnase4 kills...
Accumulated evidence indicates that the intestinal microbiota plays crucial roles in initiation and progression of colorectal cancer (CRC). However, effects tissue-associated on CRC metastasis are poorly defined. The aim this study was to explore differences bacteria between metastatic non-metastatic tissues identify potential bacterial species associate with metastasis. 16S rDNA amplicon high-throughput sequencing used test patients (n = 48) 44). microbial diversity differential were...
Background and Aims It is believed that intestinal bacteria play an indispensable role in promoting inflammation. However, the characteristics of these tissue-associated remain elusive. The aim this study to explore bacterial loads, compositions, structures noninflamed mucosa, inflamed creeping fat taken from patients with Crohn’s disease (CD). Methods Noninflamed samples were obtained 10 surgical suffering CD. Total DNA was extracted a sterile environment using aseptic techniques. V3–V4...