A5027884690- RNA Research and Splicing
- Melanoma and MAPK Pathways
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Angiogenesis and VEGF in Cancer
- Amyotrophic Lateral Sclerosis Research
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Heavy Metal Exposure and Toxicity
- MicroRNA in disease regulation
- interferon and immune responses
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- Cancer, Lipids, and Metabolism
- Per- and polyfluoroalkyl substances research
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Neurogenetic and Muscular Disorders Research
Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2021-2025
Zhejiang Cancer Hospital
2025
First Affiliated Hospital Zhejiang University
2018-2025
Heilongjiang Bayi Agricultural University
2024
Hangzhou First People's Hospital
2022-2024
Zhejiang Lab
2020-2023
Zhejiang Chinese Medical University
2022-2023
Tufts Medical Center
2012-2022
Molecular Oncology (United States)
2013-2015
Abstract Microplastics (MPs) are contaminants ubiquitously found in the global biosphere that enter body through inhalation or ingestion, posing significant risks to human health. Recent studies emerge MPs present bone marrow and damage hematopoietic system. However, it remains largely elusive about specific mechanisms by which affect stem cells (HSCs) their clinical relevance HSC transplantation (HSCT). Here, we established a long-term intake mouse model caused severe Oral gavage...
Objective Antimicrobial peptides (AMPs) play essential roles in maintaining gut health and are associated with IBD. This study is to elucidate the effect of angiogenin (ANG), an intestine-secreted AMP, on microbiota its relevance Design The ANG contribution colitis were evaluated different models co-housing faecal transplantation. ANG-regulated bacteria determined by 16S rDNA sequencing their functions analysed bacterial colonisation. species-specific antimicrobial activity underlying...
Angiogenin (ANG) promotes cell growth and survival. Under conditions, ANG undergoes nuclear translocation is accumulated in nucleolus where it stimulates ribosomal RNA (rRNA) transcription. When cells are stressed, mediates the production of tRNA-derived stress-induced small (tiRNA) that reprograms protein translation into a survival mechanism. The ribonucleolytic activity essential for both processes but how this regulated unknown. We report here ribonuclease/angiogenin inhibitor1 (RNH1)...
Metastasis of colorectal cancer (CRC) is the leading cause CRC‐associated mortality. Angiogenin (ANG), a member ribonuclease A superfamily, not only activates endothelial cells to induce tumor angiogenesis, but also targets promote cell survival, proliferation and/or migration. However, its clinical significance and underlying mechanism in CRC metastasis are still largely unknown. Here, we reported that ANG was upregulated tissues associated with patients. We then revealed enhanced growth...
Abstract Paternal environmental inputs can influence various phenotypes in offspring, presenting tremendous implications for basic biology and public health policy. However, which signals function as a nexus to transmit paternal offspring remains unclear. Here we show that of fathers with inflammation exhibit metabolic disorders including glucose intolerance obesity. Deletion mouse tRNA RNase, Angiogenin ( Ang ), abolished inflammation-induced offspring. Additionally, deletion prevented the...
Anaplastic thyroid cancer (ATC) is a rare but fatal with BRAF mutation ranging from 30 to 50%. Histone lysine lactylation represents novel epigenetic mark that translates cellular metabolic signals into transcriptional regulation. It not clear whether the Warburg effect can promote proliferation of ATC BRAFV600E via metabolite-mediated histone lactylation. Our study aimed at illustrating how restructures protein landscape boost proliferation, and determining blockade sensitize mutant...
Whereas white adipose tissue depots contribute to the development of metabolic diseases, brown and beige has beneficial effects. Here we show that CDK6 regulates adipocyte formation. We demonstrate mice lacking protein or its kinase domain (K43M) exhibit significant increases cell formation, enhanced energy expenditure, better glucose tolerance, improved insulin sensitivity, are more resistant high-fat diet-induced obesity. Re-expression in Cdk6 -/- mature precursor cells, ablation RUNX1...
Abstract The nucleolus is the organelle for ribosome biogenesis and sensing various types of stress. However, its role in regulating stem cell fate remains unclear. Here, we present evidence that nucleolar stress induced by interfering rRNA can drive 2-cell stage embryo-like (2C-like) program induce an expanded 2C-like population mouse embryonic (mES) cells. Mechanistically, integrity maintains normal liquid-liquid phase separation (LLPS) formation peri-nucleolar heterochromatin (PNH). Upon...
Abstract High spatial resolution, low background, and deep tissue penetration have made near-infrared II (NIR-II) fluorescence imaging one of the most critical tools for in vivo observation measurement. However, relatively short retention time potential toxicity synthetic NIR-II fluorophores limit their long-term application. Here, we report use infrared fluorescent proteins (iRFPs) as vitro probes permitting prolonged continuous (up to 15 months). As a representative example, iRFP713 is...
Cadmium (Cd) is a toxic heavy metal found in natural and industrial environments. Exposure to Cd can lead various metabolic disturbances, notably disrupting glucose lipid homeostasis. Despite this recognition, the direct impact of exposure on metabolism within adipose tissue, mechanisms underlying these effects, have not been fully elucidated. In study, we that accumulates tissues mice subjected exposure. Intriguingly, itself did induce significant alterations tissue under normal conditions....
Angiogenin (ANG) undergoes nuclear translocation and promotes ribosomal RNA (rRNA) transcription thereby enhancing cell growth proliferation. However, the mode of action ANG in stimulating rRNA is unclear. Here, we show that enhances formation polymerase I (Pol I) pre-initiation complex at DNA (rDNA) promoter. binds upstream control element (UCE) promoter occupancy Pol as well selectivity factor SL1 components TAFI 48 110. We also increases number actively transcribing rDNA by epigenetic...
Growing evidence demonstrates that the bioaccumulation of polystyrene nanoplastics (PS-NPs) in gastrointestinal tract has negative effects on health. Until now, little information been available regarding potential hazards PS-NPs to intestinal epithelial barriers. In this study, we employed cellular and animal models investigate adverse epithelium underlying mechanism. We found affected growth survival cells a time- concentration-dependent manner. accumulated cytoplasm, resulting an impaired...
Abstract The androgen receptor (AR) is a critical effector of prostate cancer development and progression. Androgen-dependent reliant on the function AR for growth Most castration-resistant (CRPC) remains dependent signaling survival growth. Ribosomal RNA (rRNA) essential both androgen-dependent cells. During cells, androgen-AR leads to accumulation rRNA. However, mechanism by which regulates rRNA transcription unknown. Here, investigation revealed that angiogenin (ANG), member secreted...