A5008752496- Renal cell carcinoma treatment
- Renal and related cancers
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Bladder and Urothelial Cancer Treatments
- Cardiac Fibrosis and Remodeling
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- MRI in cancer diagnosis
- Chemokine receptors and signaling
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Protein Tyrosine Phosphatases
- Circular RNAs in diseases
- DNA Repair Mechanisms
- RNA modifications and cancer
- Sperm and Testicular Function
- Bone Tissue Engineering Materials
- Signaling Pathways in Disease
- Genomics and Chromatin Dynamics
- Single-cell and spatial transcriptomics
- HER2/EGFR in Cancer Research
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
Lishui City People's Hospital
2024
Yunnan University
2024
Stanford Medicine
2020-2024
Stanford University
2024
Sun Yat-sen University
2023
First Affiliated Hospital of Wannan Medical College
2023
Tongji University
2017-2022
Shanghai East Hospital
2019-2022
Hubei University of Medicine
2021
Huazhong University of Science and Technology
2018-2020
Overabundance of Slug protein is common in human cancer and represents an important determinant underlying the aggressiveness basal-like breast (BLBC). Despite its importance, this transcription factor rarely mutated BLBC, mechanism deregulation remains unknown. Here, we report that undergoes acetylation-dependent degradation identify deacetylase SIRT2 as a key mediator post-translational mechanism. inhibition rapidly destabilizes Slug, whereas overexpression extends stability. We show...
Whereas white adipose tissue depots contribute to the development of metabolic diseases, brown and beige has beneficial effects. Here we show that CDK6 regulates adipocyte formation. We demonstrate mice lacking protein or its kinase domain (K43M) exhibit significant increases cell formation, enhanced energy expenditure, better glucose tolerance, improved insulin sensitivity, are more resistant high-fat diet-induced obesity. Re-expression in Cdk6 -/- mature precursor cells, ablation RUNX1...
Abstract Luminal breast cancers are typically estrogen receptor–positive and generally have the best prognosis. However, a subset of luminal tumors, namely B cancers, frequently metastasize recur. Unfortunately, causal events that drive their progression unknown, therefore it is difficult to identify individuals who likely relapse should receive escalated treatment. Here, we bifunctional RasGAP tumor suppressor whose expression lost in almost 50% tumors. Moreover, show two genes...
Despite advances in early diagnosis and multimodality therapy for cancers, most of lung cancer patients have been locally advanced or metastatic at the time diagnosis, suggesting highly progressive characteristic cells. The mechanisms underling invasiveness metastasis are yet to be elucidated. In present study, immunohistochemistry was performed detect expression CXCL16-CXCR6 human tissues. It demonstrated that similar CXCL12 CXCR4, CXCL16 CXCR6 were also coexpressed primary After confirming...
In spite of the clinical importance prostate cancer (PCa) bone metastasis, precise mechanisms for directed migration malignant cells remain unclear. present study, expression CXCR6 in human PCa and benign prostatic hyperplasia samples, CXCL16 osseous tissues were determined by immunohistochemistry. It was found that level protein elevated tumors, expressed positively osteocytes vivo . The vitro experiments further confirmed cell lines PC3 LNCap at both mRNA levels, exogenous has potential to...
Abstract The early diagnosis of cancers and continued monitoring tumor growth would be greatly facilitated by the development a blood-based, non-invasive, screening technique for cancer detection. Current technologies detection typically rely on imaging techniques or blood tests that are not accurate sensitive enough to definitively diagnose at its earliest stages predict biologic outcomes. By utilizing Single Molecule Arrays (SiMoA), an ultra-sensitive enzyme-linked immunosorbent assay...
DNA damage activates checkpoints that limit the replicative potential of stem cells, including differentiation. These protect against cancer development but also promote tissue aging. Because mice lacking Slug/Snai2 exhibit limited cell activity, luminobasal differentiation, and are protected from mammary cancer, we reasoned Slug might regulate in epithelial cells. Here, show facilitates efficient execution RPA32-mediated response (DDR) signaling. deficiency leads to delayed phosphorylation...
Cyclosporin A (CsA) has provided the pharmacologic foundation for organ transplantation as a calcineurin inhibitor blocking T-cell activation. We have demonstrated that CsA promoted trophoblast viability/proliferation and invasion in vitro. In present study, we further investigated intracellular signalling pathways involved enhancing cell invasiveness of human induced by CsA. showed mitogen-activated protein kinase 3 (MAPK3)/MAPK1 signaling U0126 attenuated CsA-increased viability...
Orexins have been demonstrated to play important roles in many physiological processes. However, it is not known how orexin A affects the activity of hypoglossal motoneuron (HMN) and genioglossus (GG) muscle.GG muscle electromyograms (GG-EMG) were recorded anaesthetized adult rats after or receptor antagonists applied nucleus, which neurons lesioned with neurotoxin orexin-saporin (orexin-SAP). HMN membrane potential firing from neonatal rat brain slices using whole-cell patch clamp an...
Prostate-specific membrane antigen (PSMA) is frequently overexpressed in nonprostate malignancies. This preclinical study investigated the molecular basis of application PMSA-targeting radiopharmaceuticals breast cancer subtypes.
The incidence of cardiac dysfunction after myocardial infarction (MI) continues to increase despite advances in treatment. Excessive fibrosis plays a vital role the development adverse remodeling and deterioration function. Understanding molecular cellular mechanism process developing effective therapeutics are great importance. Salvia miltiorrhiza Carthamus tinctorius extract (SCE) is indicated for angina pectoris other ischemic cardiovascular diseases China. SCE has been shown inhibit...
Sexual dimorphism and reproduction in a population of Takydromus septentrionalis on Xiushan Island Zhoushan Islands group were investigated during the breeding seasons 1989 – 1992. Most males females, approximately two years after hatchling, reached sexual maturity at 54 57 mm SVL, respectively. Adult male female T. similar SVL but quite different head size characteristics, having larger heads than females except near maturity. Mating success was apparently not related to increased SVL....
Organogenesis and tissue development occur through sequential stepwise processes leading to increased lineage restriction loss of pluripotency. An exception this appears in the adult human breast, where rare variant epithelial cells exhibit pluripotency multilineage differentiation potential when removed from signals their native microenvironment. This phenomenon provides a unique opportunity study mechanisms that lead cellular reprogramming plasticity real time. Here, we show primary...
The objective of our study was to assess the technical success, safety, and oncologic renal function outcomes CT-guided percutaneous thermal ablation for synchronous multiple masses in a single session.A retrospective analysis 23 patients (16 men 7 women; median age, 70 years) with biopsy-proven multifocal cell carcinoma (RCC) treated radiofrequency (RFA), cryoablation, or microwave (MWA) performed. Preablation, postablation, follow-up serum blood urea nitrogen, creatinine, estimated...
Although the inflammatory response triggered by damage-associated molecular patterns (DAMPs) in infarcted cardiac tissues after acute myocardial infarction (MI) contributes to repair, unrestrained inflammation induces excessive matrix degradation and fibrosis, leading development of adverse remodeling dysfunction, although mechanisms that fine tune post-MI need be fully elucidated. Protein phosphatase Mg2+/Mn2+-dependent 1L (PPM1L) is a member serine/threonine family. It originally...