A5102751529- Renal Transplantation Outcomes and Treatments
- Chemokine receptors and signaling
- Cytomegalovirus and herpesvirus research
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Bladder and Urothelial Cancer Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Endoplasmic Reticulum Stress and Disease
- Educational Robotics and Engineering
- Neurological Complications and Syndromes
- Bone Metabolism and Diseases
- Bipolar Disorder and Treatment
- Drug Transport and Resistance Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Flavonoids in Medical Research
- Organ and Tissue Transplantation Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Chronic Kidney Disease and Diabetes
- Cancer therapeutics and mechanisms
- Vascular Malformations Diagnosis and Treatment
- Potassium and Related Disorders
- Gynecological conditions and treatments
Affiliated Hospital of Nantong University
2023
Nantong University
2023
First Affiliated Hospital of GuangXi Medical University
2020-2023
Guangxi Medical University
2020-2023
Tsinghua University
2023
Capital Medical University
2010-2022
Beijing Chao-Yang Hospital
2016-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Hebei Yiling Hospital
2020
Ibero American University
2020
Abstract While lymphocytopenia is a common characteristic of patients infected by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mechanisms responsible for this depletion are unclear. Through careful inspection spleens and lymph nodes (LNs) from six cases with postmortem examinations, we observed that SARS-CoV-2 could directly infect secondary lymphoid organs to induce cell death. Immunohistochemistry demonstrated ACE2 (angiotensin-converting enzyme 2), potential...
Despite advances in early diagnosis and multimodality therapy for cancers, most of lung cancer patients have been locally advanced or metastatic at the time diagnosis, suggesting highly progressive characteristic cells. The mechanisms underling invasiveness metastasis are yet to be elucidated. In present study, immunohistochemistry was performed detect expression CXCL16-CXCR6 human tissues. It demonstrated that similar CXCL12 CXCR4, CXCL16 CXCR6 were also coexpressed primary After confirming...
Multidrug resistance (MDR) is one of the leading causes treatment failure in cancer chemotherapy. One major mechanism MDR overexpressing ABC transporters, whose inhibitors hold promising potential antagonizing MDR. Glesatinib a dual inhibitor c-Met and SMO that under phase II clinical trial for non-small cell lung cancer. In this work, we report reversal effects glesatinib to P-glycoprotein (P-gp) mediated can sensitize paclitaxel, doxorubicin, colchicine P-gp KB-C2, SW620/Ad300, transfected...
Pathological osteogenesis and inflammation possess critical significance in ankylosing spondylitis (AS). The current study aimed to elucidate the mechanisms regarding extracellular vesicle (EV)-packaged microRNA-22-3p (miR-22-3p) from M2 macrophages osteogenic differentiation of mesenchymal stem cells (MSCs) AS. EVs were initially isolated macrophages, which had been treated with either restored or depleted miR-22-3p. AS-BMSCs subsequently macrophage-derived detect BMSCs using gain-...
Objective The relationship between different autoimmune diseases and bone mineral density (BMD) fractures has been reported in epidemiological studies. This study aimed to explore the causal BMD, falls, using Mendelian randomization (MR). Methods instrumental variables were selected from aggregated statistical data of these largest genome-wide association Europe. Specifically, 12 common as exposure. Outcome included fractures. Multiple analysis methods utilized comprehensively evaluate...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder accompanied by chronic low-grade inflammation; its etiology still undefined. This study investigated the expression of CXCL12, CXCR4, and CXCR7 in PCOS rats their role regulation apoptosis. To accomplish this, we established an vivo rat model studied KGN cells (human ovarian granulosa cell line) vitro. In rats, was reduced, apoptosis rate increased, decreased BCL2 increased BAX cleaved CASPASE3 (CASP3). We further showed that...
Summary Transgenes integrated into mammalian cells are silenced rapidly. This phenomenon correlates with repressed chromatin structure marked by histone hypoacetylation. study investigated the effect of trichostatin A (TSA; a histone-deacetylase inhibitor) on EGFP expression in transfected and embryonic development after somatic cell nuclear transfer (SCNT). Porcine adult fibroblasts were pEGFP-C1 vector. Then cells, donor for SCNT, pretreated TSA, untreated being used as control. Expression...
This study was to explore the diagnostic value of magnetic resonance imaging (MRI) optimized by residual segmentation attention dual channel network (DRSA-U-Net) in diagnosis complications after renal transplantation and provide a more effective examination method for clinic. 89 patients with were selected retrospectively, all underwent MRI. The divided into control group (conventional MRI image diagnosis) observation (MRI based on DRSA-U-Net). accuracy images two groups evaluated according...
Clinical results point to a better gastrointestinal tolerability with enteric-coated mycophenolate sodium as compared mofetil. However, some transplant recipients who are treated still experience symptoms. We herein present two cases of renal severe symptoms were switched from mizoribine, and the symptom reversal effects evaluated using Gastrointestinal Symptom Rating Scale. The this study showed significant improvement in after converting mizoribine.
Objective To investigate the clinical features of bilateral native pelvic and ureteral transitional cell carcinoma (TCC) in renal transplant patients. Methods A retrospective analysis was carried out on 16 patients with TCC after kidney transplantation.The mean time between transplantation diagnosis upper urinary 56. 2 ± 33. 0 months.Two were suffered from at same time. The interval tract operations remaining 14 cases 8. 6 6. 7 months. Hematuria hydronephrosis kidneys main symptoms targets...