A5100735634- Mathematical and Theoretical Epidemiology and Ecology Models
- Complex Network Analysis Techniques
- Opinion Dynamics and Social Influence
- Evolution and Genetic Dynamics
- COVID-19 epidemiological studies
- Sports Performance and Training
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Hepatitis B Virus Studies
- Evolutionary Game Theory and Cooperation
- Cancer Immunotherapy and Biomarkers
- Hepatitis C virus research
- Winter Sports Injuries and Performance
- Sports Dynamics and Biomechanics
- Chaos control and synchronization
- Nonlinear Dynamics and Pattern Formation
- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Mycobacterium research and diagnosis
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cell Adhesion Molecules Research
- Innovation Diffusion and Forecasting
Qinghai University
2024
North University of China
2013-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2023
University of Oklahoma Health Sciences Center
2023
Capital Medical University
2019-2023
Beijing Chest Hospital
2019-2023
Sun Yat-sen University
2023
Southern Medical University Shenzhen Hospital
2023
Nankai University
2023
Hangzhou Hospital of Traditional Chinese Medicine
2023
Abstract Background Inadequate immunity caused by poor immune surveillance leads to tumorigenesis, while excessive due breakdown of tolerance causes autoimmune genesis. Although the function during onset these two processes appears be distinct, underlying mechanism is shared. To date, gene expression data for large bodies clinical samples are available, but resemblances tumorigenesis and genesis in terms responses remains summed up. Methods Considering high disease prevalence, we chose...
The present study aimed to determine the up-to-date prevalence, awareness, treatment, and control of dyslipidemia, their distribution related influencing factors in adults Beijing, China.A cross-sectional was conducted 2008, using a four-stratified cluster sampling. Data from questionnaire, physical examination, blood sampling were obtained 5761 aged 18-79 years.The prevalence high TC, LDL-C, low HDL-C TG 12.2%, 17.9%, 12.0% 15.1%, respectively. dyslipidemia 35.4% (42.9% men 30.1% women),...
Selenoprotein V (SELENOV) is a new and the least conserved member of selenoprotein family. Herein we generated Selenov knockout (KO) mice to determine its in vivo function. The KO led 16-19% increases (P < 0.05) body weight that were largely due 54% higher fat mass accumulation, compared with wild-type (WT) controls. extra accumulation was mediated by up-regulations genes proteins involved lipogenesis (Acc, Fas, Dgat, Lpl; up 40%-1.1-fold) down-regulations lipolysis (Atgl, Hsl, Ces1d, Cpt1a;...
Fibroblasts account for more than 95% of dermal cells maintaining structure and function. However, UVA penetrates the dermis causes oxidative stress that damages accelerates skin aging. Puerarin, main active ingredient Puerariae lobata, has been demonstrated to withstand caused by a variety factors. there are limited findings on whether puerarin protects fibroblasts from UVA-induced damage. The effects human (HSF) under were investigated in this study. It is found upregulates antioxidant...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) secreted by tumors was reported as a deleterious factor that led to the reduction of lymphocyte infiltration and poorer efficacy ICIs
Candida vulturna belongs to the haemulonii species complex and is phylogenetically related C. auris. We report a outbreak among persons in Shanxi Province, China, during 2019-2022. Isolates were resistant multiple antifungal drugs exhibited enhanced adhesion biofilm formation properties.
Abstract The androgen receptor (AR) is a critical effector of prostate cancer development and progression. Androgen-dependent reliant on the function AR for growth Most castration-resistant (CRPC) remains dependent signaling survival growth. Ribosomal RNA (rRNA) essential both androgen-dependent cells. During cells, androgen-AR leads to accumulation rRNA. However, mechanism by which regulates rRNA transcription unknown. Here, investigation revealed that angiogenin (ANG), member secreted...
Objectives: This study aimed to investigate the Th1/Th2 cells in peripheral blood of PCOS patients, and assess potential correlation between imbalance obesity.Methods: Thirty-nine patients 23 age-matched controls were enrolled. The PBMCs obtained before pharmacological intervention women with or without PCOS. profiles Th1 (IFN-γ) Th2 (IL-4) cytokines CD3+CD− T lymphocyte subsets analyzed by flow cytometry. Plasma sex hormones including E2, T, FSH, LH, FINS, FPG measured, together BMI, WC,...
Abstract Cancer stem cells (CSCs) are an obstacle in cancer therapy and a major cause of drug resistance, recurrence, metastasis. Available treatments, targeting proliferating cells, not effective eliminating quiescent CSCs. Identification CSC regulators will help design therapeutic strategies to sensitize drug-resistant CSCs for chemo-eradication. Here, we show that angiogenin plexin-B2 regulate the stemness prostate CSCs, inhibitors angiogenin/plexin-B2 chemotherapy. Prostate capable...
Although the tumor mutation burden (TMB) was reported as a biomarker for immunotherapy of various cancers, whether it can effectively predict survival prognosis in breast cancer patients remains unclear. In this study, prognostic value TMB and its correlation with immune infiltration were explored by using multigroup studies.The somatic data 986 obtained from TCGA database. Breast divided into low-TMB group high-TMB according to quartile scores. The differentially expressed genes (DEGs)...
Recently a discrete-time prey-predator model with Holling type IIwas discussed for its bifurcations so as to show complicateddynamical properties. Simulation illustrated the occurrence ofinvariant cycles. In this paper we first clarify parametricconditions of non-hyperbolicity, correcting known result. Thenwe apply center manifold reduction and method normalforms completely discuss codimension 1. We givebifurcation curves analytically transcritical bifurcation,flip bifurcation Neimark-Sacker...
Abstract Amyloid plaques are one of the hallmarks Alzheimer's disease (AD). The lack specific probes that can detect individual senile in AD has prompted development magnetic resonance imaging (MRI) probes. In this study, based on DTPA‐gadolinium (III) and congo red (CR), a novel MRI probe precursor CR‐BSA‐(Gd‐DTPA) n was successfully synthesized. Its ability to bind amyloid evaluated by brain sections from APP/PS1 transgenic mice. specificity for Aβ further demonstrated immunohistochemistry...
Although significant advances have been made toward understanding the molecular mechanisms underlying effect of propofol on tumor cell metastasis, less is known regarding how membrane and cytoskeletal ultrastructure are affected in this process. Here, we investigated relationship between morphology size, which features mainly defined by cytoskeleton.To confirm effects migratory ability human cervical carcinoma cells, migration invasion were examined through scratch wound healing transwell...
High-risk population of blood donation increases the prevalence transmit blood-borne diseases and harm safety. Syphilis accounts for approximately 10% commonly sexually transmitted diseases. The risk factors donors infected with syphilis are also other borne objective study is to investigate seroprevalence on among donors, analyze status high-risk population.A retrospective was conducted in Chengdu Blood Center during 2005 2017. Serological test results volunteer were collected. Conditional...