A5044652732- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Probiotics and Fermented Foods
- Fungal and yeast genetics research
- Yeasts and Rust Fungi Studies
- Antimicrobial Resistance in Staphylococcus
- Antimicrobial Peptides and Activities
- Syphilis Diagnosis and Treatment
- Plant Disease Resistance and Genetics
- Body Image and Dysmorphia Studies
- Plant Pathogens and Fungal Diseases
- Fungal Biology and Applications
- Infectious Diseases and Mycology
- Herbal Medicine Research Studies
Shanghai Pulmonary Hospital
2024-2025
Tongji University
2024-2025
Huashan Hospital
2020-2025
Fudan University
2020-2025
State Key Laboratory of Genetic Engineering
2020-2025
Shanghai Micro Satellite Engineering Center
2023-2024
Chinese Academy of Sciences
2018-2020
University of Chinese Academy of Sciences
2018-2020
Institute of Microbiology
2018-2020
The emerging human fungal pathogen Candida auris has become a serious threat to public health. This spread 10 provinces in China as of December 2023. Here we describe 312 C. auris-associated hospitalizations and 4 outbreaks healthcare settings from 2018 Three genetic clades have been identified during this period. Molecular epidemiological analyses indicate that introduced local transmission occurred multiple instances China. Most isolated (98.7%) exhibited resistance fluconazole, while only...
Morphological plasticity has historically been an indicator of increased virulence among fungal pathogens, allowing rapid adaptation to changing environments. Candida auris identified as emerging multidrug-resistant human pathogen global importance. Since the discovery this species, it thought that C. is incapable filamentous growth. Here, we report filamentation and three distinct cell types in auris: typical yeast, filamentation-competent (FC) cells. These form a novel phenotypic switching...
The human fungal pathogen Candida tropicalis is widely distributed in clinical and natural environments. It known to be an obligate diploid organism with incomplete atypical sexual cycle. Azole-resistant C. isolates have been observed increasing prevalence many countries recent years. Here, we report that tebuconazole (TBZ), a triazole fungicide used agriculture, can induce ploidy plasticity the formation of haploid cells . evolved strains variations exhibit cross-resistance between TBZ...
Candida auris is a newly emerging fungal pathogen of humans and has attracted considerable attention from both the clinical basic research communities. Clinical isolates C. are often resistant to one or more antifungal agents. To explore how resistance develops, we performed experimental evolution assays using fluconazole-susceptible isolate (BJCA001). After series passages through medium containing increasing concentrations fluconazole, cells acquired resistance. By sequencing comparing...
Candida vulturna belongs to the haemulonii species complex and is phylogenetically related C. auris. We report a outbreak among persons in Shanxi Province, China, during 2019-2022. Isolates were resistant multiple antifungal drugs exhibited enhanced adhesion biofilm formation properties.
The fungal pathogen Candida auris has emerged as a new threat to human health. We previously reported the first isolate of C. (BJCA001) in China, which belongs South Asian clade (I) and was susceptible all antifungals tested. In this study, we report isolation drug-resistant strain (BJCA002) from same city (Beijing). Strain BJCA002 African (III) is resistant fluconazole amphotericin B based on tentative MIC breakpoints. Taking advantage two isolates with distinct antifungal susceptibility...
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Several human fungal pathogens, including drug-resistant