A5072162227- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Fungal Infections and Studies
- Nosocomial Infections in ICU
- Infective Endocarditis Diagnosis and Management
- Antibiotic Use and Resistance
- Vibrio bacteria research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Tuberculosis Research and Epidemiology
- Nail Diseases and Treatments
- Bacterial biofilms and quorum sensing
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Hepatitis Viruses Studies and Epidemiology
- Mycobacterium research and diagnosis
- Escherichia coli research studies
- Probiotics and Fermented Foods
- Ocular Infections and Treatments
- Autoimmune Bullous Skin Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Plant Pathogens and Fungal Diseases
- Clostridium difficile and Clostridium perfringens research
- Enterobacteriaceae and Cronobacter Research
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
The emerging human fungal pathogen Candida auris has become a serious threat to public health. This spread 10 provinces in China as of December 2023. Here we describe 312 C. auris-associated hospitalizations and 4 outbreaks healthcare settings from 2018 Three genetic clades have been identified during this period. Molecular epidemiological analyses indicate that introduced local transmission occurred multiple instances China. Most isolated (98.7%) exhibited resistance fluconazole, while only...
Candida auris is an emerging multidrug-resistant fungal pathogen worldwide. To date, it has not been reported in Guangdong, China. For the first time, we 7 cases of C. candidemia from two hospitals Guangdong. The clinical and microbiological characteristics these were investigated carefully. Two geographic clades, i.e., III I, found popular different by whole genome sequencing analyses. All isolates bloodstream resistant to fluconazole, 5 which belonged Clade harboring VF125AL mutation ERG11...
Strongyloides stercoralis is an opportunistic pathogenic parasite. Most individuals with normal immune function may not exhibit significant symptoms, and the signs are atypical, which can easily lead to missed diagnoses delayed treatment. People underlying diseases weakened immunity prone develop severe conditions after infection stercoralis. We report immunocompromised patient in whom pathogen was initially detectable using traditional parasitic detection techniques. However, identified...
Though droplet digital PCR (ddPCR) has emerged as a promising tool for early pathogen detection in bloodstream infections (BSIs), more studies are needed to support its clinical application widely due different ddPCR platforms with discrepant diagnostic performance. Additionally, there is still lack of data reveal the association between loads detected by and corresponding BSIs. In this prospective study, 173 patients suspected BSIs were enrolled. A multiplex assay was used detect 18...
Enterobacter cloacae has recently emerged as one of the most common carbapenem-resistant Enterobacteriaceae. The emergence and spread metallo-β-lactamase-producing E. have posed an immediate threat globally. Here, we investigated molecular characteristics 84 (CREL) collected from three tertiary hospitals in China between 2012 2016. Species identification antimicrobial susceptibility testing were performed using a VITEK-2 system. Carbapenems, polymyxins B, tigecycline tested by broth...
Bloodstream infection (BSI) caused by carbapenem resistant Klebsiella pneumoniae (CRKP), especially in elderly patients, results higher morbidity and mortality. The purpose of this study was to assess risk factors associated with CRKP BSI short-term mortality among patients China.In retrospective cohort study, we enrolled 252 inpatients aged ≥ 65 years KP from January 2011 December 2020 China. Data regarding demographic, microbiological characteristics, clinical outcome were collected.Among...
Acinetobacter baumannii is a nosocomial pathogen which reported as major cause of morbidity and mortality in intensive care units (ICUs). However, there lack analysis focused on multidrug-resistant (MDRAB) infection among patients from pediatric unit (PICU) China. The aim this study was to investigate the molecular characterization MDRAB isolated PICU. In study, 86 isolates were collected PICU patients, First Affiliated Hospital Sun Yat-sen University. minimal inhibitory concentrations...
Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE) infections have become a global health threat. Controlling CRE transmission in hospitals is increasingly dependent on the use of disinfectants to restrict risk infection. Here, susceptibility patient-derived carbapenem resistant Klebsiella pneumoniae (CRKP) and Escherichia coli (CREC) strains against three common determinants resistance were investigated. Methods The minimum inhibitory concentrations (MICs) bactericidal (MBCs)...
Fusarium Solani is the principal pathogen associated with fungal keratitis. As a sensitive drug to F. Solani, natamycin (NAT) was limited by poor penetration and low bioavailability in clinical application. The aim of this study develop new type tri-block polymer nanoparticle-gel complex (Gel@PLGA-PEI-PEG@NAT) for delivering NAT evaluate its physicochemical properties, antifungal activity, safety, penetrability, adhesion, efficacy treating keratitis.PLGA-PEI-PEG@NAT prepared characterized...
Background The emergence of ceftazidime–avibactam (CZA) resistance among carbapenem-resistant Klebsiella pneumoniae (CRKP) is major concern due to limited therapeutic options. Methods In this study, 10 CRKP strains were isolated from different samples a patient with infection receiving CZA treatment. Whole-genome sequencing (WGS) and conjugation experiments performed determine the transferability carbapenem gene. Results This began KPC-2-producing K. (CZA MIC = 2 μg/mL, imipenem ≥ 16 μg/mL)....
Resistance against ceftazidime-avibactam (CZA) in carbapenem-resistant Pseudomonas aeruginosa (CRPA) is emerging. This study was aimed at detecting the prevalence and molecular characteristics of CZA-resistant CRPA clinical isolates Guangdong Province, China. The antimicrobial susceptibility profile these strains determined. A subset 16 analysed by whole-genome sequencing (WGS). Genetic surroundings carbapenem resistance genes pan-genome-wide association analysis were further studied. Of 250...
This study aimed to examine the impact of an intervention carried out in 2011 combat multi-drug resistance and outbreaks imipenem-resistant Acinetobacter baumannii (IRAB), explore its mechanism.A total 2572 isolates A. baumannii, including 1673 IRAB isolates, were collected between 2007 2014. An was implemented control outbreaks. Antimicrobial susceptibility tested by calculating minimal inhibitory concentrations (MICs), typed using pulsed-field gel electrophoresis (PFGE). Resistance...
BACKGROUND: To investigate the clinical characteristics and risk factors of human immunodefi ciency virus (HIV)-negative patients with Talaromyces marneff ei (T.marneff ei) infection. METHODS:We retrospectively collected information HIV-negative T. infection from January 1, 2010 to June 30, 2019, analyzed related poor prognosis.RESULTS: Twenty-fi ve cases aging 22 79 years were included.Manifestations included fever, cough, dyspnea, chest pain or distress, lymphadenopathy, ear, nose, throat...
(1) Background: The need to elucidate the microbial patterns in preservation fluid and explore their relationship with early infection-related events post kidney transplant investigate antimicrobial resistance effects of preemptive antibiotic therapy. (2) Methods: This retrospective study analyzed clinical data 514 donors 808 recipients from April 2015 October 2020. Clinical donor recipient characteristics, microbes, infections (≤30 days), probable donor-derived (P-DDIs), therapy was...
Abstract Study Objectives This study aimed to establish a population pharmacokinetic (PPK) model of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction and explore the optimal dosing strategies specific clinical scenarios for invasive fungal infections (IFIs) caused by common Aspergillus Candida species. Design Prospective pharmacokinetics study. Setting The intensive care unit tertiary‐care medical center. Patients A total 297 plasma VRC concentrations from 26...
Infection with Vibrio vulnificus is notorious for its atypical clinical manifestations and irreversible disease progression. Lysine acetylation a conserved post-translational modification (PTM) that plays critical regulatory role in diverse cellular processes. However, little known about the of lysine on pathogenesis V. vulnificus. Here, we report complete genome sequence global profile protein Vv180806, highly cefoxitin resistant strain isolated from mortality case. The assembled comprised...
Abstract Background In recent years, Candida parapsilosis is recognized as a species complex and composed of sensu stricto, orthopsilosis metapsilosis . prosthetic valve endocarditis (PVE) rare the survival rate still low despite optimal therapeutic strategies. our report, it novel to report cases PVE at identify using MALDI-TOF MS. Case presentation A series 4 from institution was reported. Three were infected by stricto one metapsilosis. The condition two got better other died. Conclusions...
Background The burden of cryptococcosis in mainland China is enormous. However, the vitro characterization and molecular epidemiology Guangdong, a key region with high incidence fungal infection China, are not clear. Methods From January 1, 2010, to March 31, 2019, clinical strains Cryptococcus were collected from six medical centres Guangdong. information characteristics analysed. Furthermore, types determined. Results A total 84 collected, mostly male young or middle-aged adult patients....