A5056090848- Sepsis Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Hemodynamic Monitoring and Therapy
- RNA modifications and cancer
- Cancer-related gene regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Circular RNAs in diseases
- Antifungal resistance and susceptibility
- Machine Learning in Healthcare
- Biomarkers in Disease Mechanisms
- Palliative Care and End-of-Life Issues
- Extracellular vesicles in disease
- Nutrition and Health in Aging
- Nosocomial Infections in ICU
- RNA Research and Splicing
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Trauma and Emergency Care Studies
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetic and Kidney Cyst Diseases
- Esophageal and GI Pathology
- Platelet Disorders and Treatments
The First Affiliated Hospital, Sun Yat-sen University
2017-2025
Sun Yat-sen University
2015-2025
Rice University
2022
Sun Yat-sen Memorial Hospital
2022
Third Affiliated Hospital of Sun Yat-sen University
2015
ABSTRACT Introduction: The objective of our study was to explore the association between sex and clinical outcome in sepsis patients a large, diverse population. Materials Methods: We analyzed 6,134 adult with from critical care units Beth Israel Deaconess Medical Center 2001 2012. Study data were retrospectively extracted Information Mart for Intensive Care-III, multiparameter intensive database. Results: There 2,677 (43.6%) female 3,457 (56.4%) male patients. Compared patients, had higher...
ObjectivesWe investigated the impact of obesity (proxied as body mass index (BMI)), on short- and long-term mortality in sepsis patients.MethodsWe conducted a retrospective analysis with adult ICU patients US medical institution from 2001 to 2012 MIMIC-III database. The WHO BMI categories were used. Multivariate logistic regression assessed relationships between 30-day 1-year mortality.ResultsIn total, 5563 enrolled. Obese tended be younger (P < 0.001), female acquire worse SOFA scores...
Hepatocellular carcinoma (HCC) is a major challenge for human health. Finding reliable diagnostic biomarkers and therapeutic targets HCC highly desired in the clinic. Currently, circulating exosomal lncRNA promising biomarker diagnosis of cancer also potential target therapy. Here, value panel based on THEMIS2-211 PRKACA-202, superior to that AFP, was identified diagnosing HCC. Besides, performance alone exceeds AFP early-stage patients (stage I). Furthermore, expressed tissues correlated...
To investigate the prognostic value of intra-abdominal pressure (IAP) among patients with orthotopic liver transplantation (OLT). We enrolled adult admitted in Department Critical Care Medicine First Affiliated Hospital Sun Yat-sen University after undergoing from January 2018 to March 2022. A total 382 were included, 73 who died within 1 year admission. Intra-abdominal Hypertension (IAH) was defined as a sustained IAP ≥ 12 mmHg. The incidence IAH transplant 46.2%. and sequential organ...
Risk stratification plays an essential role in the decision making for sepsis management, as existing approaches can hardly satisfy need to assess this heterogeneous population. We aimed develop and validate a machine learning model predict in-hospital mortality critically ill patients with sepsis.Adult fulfilling definition of Sepsis-3 were included at large tertiary medical center. Relevant clinical features extracted within first 24 h ICU, re-classified into different genres, utilized...
Integrator complex subunit 6 (INTS6) was found to play a tumour suppressing role in certain types of solid tumours. In this study, we wanted determine the expression level INTS6 hepatocellular carcinoma (HCC) and evaluate its clinical characteristics mechanisms HCC patients (Lui Lu, European Journal Cancer, 51:S94, 2015).First, used microarray analysis explore mRNA levels paired normal liver tissues; second, qRT-PCR measure cohort 50 tissues adjacent third, Western blot analyses detect...
In this study, we aimed to determine whether the pseudogene integrator complex subunit 6 1 (INTS6P1) in plasma could be used as a novel approach screen for and detect hepatocellular carcinoma (HCC). We explored clinical role of INTS6P1: First, expression level INTS6P1 was measured cohort 33 HCC tissue samples adjacent normal liver tissue, next, detected culture medium tumor cells cellular experiment, last, diagnostic performance examined an independent 100 people. The remarkably...
Abstract Study Objectives This study aimed to establish a population pharmacokinetic (PPK) model of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction and explore the optimal dosing strategies specific clinical scenarios for invasive fungal infections (IFIs) caused by common Aspergillus Candida species. Design Prospective pharmacokinetics study. Setting The intensive care unit tertiary‐care medical center. Patients A total 297 plasma VRC concentrations from 26...
This study aimed to determine the prognostic impact of neutrophil-to-lymphocyte ratio (NLR) in critically ill trauma patients. retrospective involved adult patients from 335 intensive care units (ICUs) at 208 hospitals stored eICU database. The primary outcome was ICU mortality. lengths and hospital stay were calculated as secondary outcomes. multivariable logistic regression model used identify independent predictors To effect NLR on survival, a 15-day survival curve used. A total 3,865...
Data on the distribution of voriconazole (VRC) in human peritoneal cavity are sparse. This prospective study aimed to describe pharmacokinetics intravenous VRC fluid critically ill patients. A total 19 patients were included. Individual pharmacokinetic curves, drawn after single (first dose day 1) and multiple (steady-state) doses, displayed a slower rise lower fluctuation concentrations than plasma. Good but variable penetration into was observed, median (range) fluid/plasma ratios area...
Introduction: Sepsis is one of the leading causes human mortality. There a paucity clinical trials informing specific questions faced by sepsis. The ClinicalTrials.gov registry offers an opportunity to evaluate in Here we analyze 25 years sepsis trial research. Methods: We examined interventional registered with from 1995–2020, focusing on study conditions and interventions identify sepsis-related trials. Relevance ID was manually confirmed for each programmatically identified trial. were...
Introduction: During resuscitation in sepsis, early microcirculation changes are better predictors of outcome than macrocirculation. The degradation glycocalyx coated on the luminal surface vascular endothelial cells is considered to be one causes dysfunction sepsis. Syndecan-1, shedding component glycocalyx, can reflect glycocalyx. Intravital microscopy directly observe sublingual by sidestream dark field (SDF) imaging. This study was combine plasma syndecan-1 with parameters predict...
<title>Abstract</title> <bold>Background</bold>: The appropriate range of central venous pressure (CVP) in sepsis patients remains controversial. aim this study was to investigate the optimal CVP and septic shock admitted intensive care unit.<bold>Methods: </bold>We performed a retrospective with adult records based on eICU Collaborative Research Database. Cases were divided into three groups according mean level during ICU stay: low (< 8 mmHg), normal (8–12 high (> 12 mmHg). Baseline...
Abstract Background: Risk stratification plays an essential role in the decision-making of sepsis management, whereas neither a single serum biomarker nor traditional scoring tools can satisfy need to assess this heterogeneous population comprehensively. The study intended develop interpretable machine learning model for predicting in-hospital mortality critically ill patients with sepsis. Methods: Adult fulfilling definition Sepsis-3 were included Medical Information Mart Intensive Care...
Abstract Background Nutritional therapy is essential for patients in the intensive care unit (ICU), when optimal caloric goals remain controversial, especially late acute phase (after day 3). This study aimed to investigate impact of hypocaloric versus normocaloric feeding this period. Methods We conducted a retrospective analysis within an up-to-date large database, including adult who were admitted tertiary hospital from 2008 2019, and stayed ICU over one week. Individuals divided...
A 59-years-old woman presented to the emergency department with sudden onset of intermittent hematemesis and melena. The patient had a history stage IV cervical cancer, sigmoid colostomy (because rectovaginal fistula). complete blood count showed normocytic anemia (79 g/l) other laboratory evaluation elevation ammonia (38 µmol/l). total bilirubin, transaminase creatinine level were normal. Upper endoscopy revealed hemorrhage esophageal varices that was stopped by local treatment combinations...
Abstract Background: The rise of platelets in sepsis patients with thrombocytopenia can lead to an improvement clinical outcomes. We aimed probe whether the rebound platelet count could be a predictor good prognosis large, diverse population. Methods: All were initially stratified according nadir counts (very low<50´10 9 /L, intermediate-low 50 ´ 10 99 low 100 149 normal 150 399 or thrombocytosis > 400 /L). delta (DPC) was defined as difference between last prior transfer death and...