A5101630682- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV, Drug Use, Sexual Risk
- Corneal surgery and disorders
- Antibiotics Pharmacokinetics and Efficacy
- Glaucoma and retinal disorders
- Substance Abuse Treatment and Outcomes
- Neurological Disease Mechanisms and Treatments
- Alcohol Consumption and Health Effects
- Intensive Care Unit Cognitive Disorders
- Lung Cancer Treatments and Mutations
- Barrier Structure and Function Studies
- Renin-Angiotensin System Studies
- Diabetes Management and Research
- Ocular Oncology and Treatments
- Inflammasome and immune disorders
- Healthcare and Venom Research
- Multiple Myeloma Research and Treatments
- Proteoglycans and glycosaminoglycans research
- Hormonal Regulation and Hypertension
- Nosocomial Infections in ICU
- Intracerebral and Subarachnoid Hemorrhage Research
- Renal Transplantation Outcomes and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Sentiment Analysis and Opinion Mining
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
Johns Hopkins University
2024
Peking Union Medical College Hospital
2009-2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2023
Sun Yat-sen University
2020-2023
Roche (Switzerland)
2023
Regeneron (United States)
2023
Qingdao University
2008-2022
Affiliated Hospital of Qingdao University
2008-2022
Xiamen University
2021
To characterize the pharmacokinetics (PK) of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction.Patients dysfunction intensive care unit (ICU) were included prospectively. The Child-Pugh score was used to categorize degree dysfunction. initial VRC dosing regimen comprised a loading dose 300 mg every 12 h for first 24 h, followed by 200 h. PK curves (PK curve 1) drawn within one interval 17 patients; second 2) after minimum seven doses patients. parameters...
Abstract Study Objectives This study aimed to establish a population pharmacokinetic (PPK) model of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction and explore the optimal dosing strategies specific clinical scenarios for invasive fungal infections (IFIs) caused by common Aspergillus Candida species. Design Prospective pharmacokinetics study. Setting The intensive care unit tertiary‐care medical center. Patients A total 297 plasma VRC concentrations from 26...
Glycogen synthase kinase-3β (GSK-3β), a serine/threonine protein kinase, is widely distributed in mammalian brains. Since GSK-3β plays vital role the development of neurodegenerative disorders, present study was designed to investigate blood–brain barrier (BBB) permeability aged mice. Morris water maze test used examine mouse cognitive function. BBB examined by leakage fluorescence signals low-molecular weight dextran. inhibitor, 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8),...
Although various factors were reported to be related post-herpetic neuralgia (PHN), studies based on adequate and comprehensive data absent. Data was extracted from cases of hospitalized patients with herpes zoster in dermatology department, Sichuan hospital traditional Chinese medicine range December, 2011 February, 2018, then cleaned build prediction model TREENET algorithms. Following evaluated the by ROC confusion matrix, variables importance ranking dependency analysis performed,...
Data on the distribution of voriconazole (VRC) in human peritoneal cavity are sparse. This prospective study aimed to describe pharmacokinetics intravenous VRC fluid critically ill patients. A total 19 patients were included. Individual pharmacokinetic curves, drawn after single (first dose day 1) and multiple (steady-state) doses, displayed a slower rise lower fluctuation concentrations than plasma. Good but variable penetration into was observed, median (range) fluid/plasma ratios area...
The pharmacokinetics (PK) of several drugs including antimicrobials might be highly altered during extracorporeal membrane oxygenation (ECMO) therapy. We present the change voriconazole (VRC) PK ECMO in a critically ill patient who received intravenous VRC at maintenance dose 200 mg every 12 h for empirical antifungal Two profiles were drawn before and after initiation Though trough levels (both C0 C12) with slightly lower than that without (12.58 12.84 vs. 14.02 μg/mL), peak area under...
Abstract Background The prevalence of heart failure is continually increasing, impacting various regions and populations. application online communities in healthcare has emerged as a significant area research. However, the exploration Chinese public attitudes content regarding from popular perspective remains uncharted. Objective Describing sentimental main themes Posts by Users on “Heart Failure Bar” Baidu Tieba. Methods Data were processed using Python programming. Comments "Heart Bar"...
Preoperative opioid use (OU) is a strong risk factor for poor postoperative outcomes in other surgical populations but has not been explored lung transplant (LT) recipients nationally. The study identified adult (aged ≥18 years) US from 2011 to 2021 the Scientific Registry of Transplant Recipients with prescription data through pharmacy set. Posttransplantation ventilatory support, infection, and mortality by pretransplantation OU (prescription fill ≤6 months before transplantation) were...
To study the changes of contents inflammatory mediators in serum polytrauma patients with acute lung injury (ALI) and their correlation disease. Patients suffering from multiple trauma combined ALI were selected as group (n = 54). without considered control 117). The severity disease two groups was assessed. Arterial blood extracted for gas analysis. Venous to detect tumor necrosis factor-α, interleukin-1β (IL-1β), IL-10, granulocyte-macrophage colony stimulating factor, NO, endothelin-1....
Background Penetrating keratoplasty (PKP) has become an effective method of treatment for fungal keratitis in recent years,but the application timing glucocorticoids after PKP is still unclear.Literature reported that concentration tear (1,3)-β-D-glucan was significantly higher than normal.Objective This study to investigate change before and explore duration anti-fungal drugs glucocorticoids.Methods protocol approved by ethic committee Affiliated Hospital Qingdao University.A serial...
Objective To study the influence of edaravone on serum IL-6,TNF-α,ET,sICAM-1 and MCP-1 in acute cerebral hemorrhage patients,discuss protective mechanism hemorrhage.Methods 100 patients with were randomly divided into treatment group control (50 cases),the levels detcted by ELSA at pretherapy after given treatment.Neurological functional deficit scores utilized for assessment treatment.A healthy which approximately matched experimental included 30 persons.Results The both two groups...
Objective To study the effect of CXCR4 inhibitor AMD3465 on proliferation and invasion lung carcinoma cell lines. Methods The line A549 was cultured divided into 50 mg/L group, 100 200 group treated with DMEM containing different dosage control without drug. After 12 h, 24 h 48 number cells were detected. mRNA expression genes detected. Results 12 after treatment, OD values significantly lower than less differences between ADM3456 larger higher AMD3465(P<0.05); hours CyclinD1,...
Abstract The aim of the study was to identify specific clinical and serum protein biomarkers that are associated with longitudinal outcome RA-associated interstitial lung disease（RA-ILD). 60 RA patients serological profiles were assessed by HRCT pulmonary function tests (PFTs) at baseline (Year 0) 5 years post enrollment 5). Progression versus non-progression defined based on changes in Quantitative Modified scores PFTs over time. Specific samples Year Multiplex enzyme-linked immunosorbent...