A5100751700- Organ Transplantation Techniques and Outcomes
- Sepsis Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Antifungal resistance and susceptibility
- Transplantation: Methods and Outcomes
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Air Quality Monitoring and Forecasting
- Organ Donation and Transplantation
- Hemodynamic Monitoring and Therapy
- Cytomegalovirus and herpesvirus research
- Neurological Complications and Syndromes
- Kruppel-like factors research
- Mycobacterium research and diagnosis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Central Venous Catheters and Hemodialysis
- Electrolyte and hormonal disorders
- Machine Learning in Healthcare
- Intensive Care Unit Cognitive Disorders
- Cancer therapeutics and mechanisms
- Currency Recognition and Detection
The First Affiliated Hospital, Sun Yat-sen University
2015-2025
Sun Yat-sen University
2015-2025
Shanghai Public Health Clinical Center
2025
University of Oklahoma
2022
Intensive Care Society
2020
University of Iowa
2017
Third Affiliated Hospital of Sun Yat-sen University
2007-2010
National Natural Science Foundation of China
2006
Whalen Biomedical
1997
Ischemia and reperfusion injury (IRI) is an inevitable event in conventional organ transplant procedure associated with significant mortality morbidity post-transplantation. We hypothesize that IRI avoidable if the blood supply for not stopped, thus resulting optimal outcomes. Here we described first case of a novel called ischemia-free transplantation (IFOT) patients end-stage liver disease. The graft severe macrovesicular steatosis was donated from 25-year-old man. recipient 51-year-old...
ABSTRACT Introduction: The objective of our study was to explore the association between sex and clinical outcome in sepsis patients a large, diverse population. Materials Methods: We analyzed 6,134 adult with from critical care units Beth Israel Deaconess Medical Center 2001 2012. Study data were retrospectively extracted Information Mart for Intensive Care-III, multiparameter intensive database. Results: There 2,677 (43.6%) female 3,457 (56.4%) male patients. Compared patients, had higher...
ObjectivesWe investigated the impact of obesity (proxied as body mass index (BMI)), on short- and long-term mortality in sepsis patients.MethodsWe conducted a retrospective analysis with adult ICU patients US medical institution from 2001 to 2012 MIMIC-III database. The WHO BMI categories were used. Multivariate logistic regression assessed relationships between 30-day 1-year mortality.ResultsIn total, 5563 enrolled. Obese tended be younger (P < 0.001), female acquire worse SOFA scores...
Risk stratification plays an essential role in the decision making for sepsis management, as existing approaches can hardly satisfy need to assess this heterogeneous population. We aimed develop and validate a machine learning model predict in-hospital mortality critically ill patients with sepsis.Adult fulfilling definition of Sepsis-3 were included at large tertiary medical center. Relevant clinical features extracted within first 24 h ICU, re-classified into different genres, utilized...
<sec><title>BACKGROUND</title>Barriers to the diagnosis and treatment of rifampicin-resistant TB (RR-TB) have not been fully elucidated. This study aimed map diagnostic delays among patients with RR-TB in China investigate related factors.</sec><sec><title>METHODS</title>Between June July 2023, pathways were obtained through interviews at eight hospitals across China. Information on service was collected via...
To investigate the prognostic value of intra-abdominal pressure (IAP) among patients with orthotopic liver transplantation (OLT). We enrolled adult admitted in Department Critical Care Medicine First Affiliated Hospital Sun Yat-sen University after undergoing from January 2018 to March 2022. A total 382 were included, 73 who died within 1 year admission. Intra-abdominal Hypertension (IAH) was defined as a sustained IAP ≥ 12 mmHg. The incidence IAH transplant 46.2%. and sequential organ...
<title>Abstract</title> Plasma membrane integrity is vital not only for cell survival but also nearly all aspects of functioning. Mechanical stress can cause plasma damage, it known whether there are large molecules (proteins) that control integrity. Here we constructed a 384-well cellular stretch system delivers precise, reproducible mechanical strain to adherent cells. Using the system, screened 10,843 siRNAs targeting 2,726 multi-pass transmembrane proteins stretch-induced permeability...
To characterize the pharmacokinetics (PK) of polymyxin B in Chinese critically ill patients. The factors significantly affecting PK parameters are identified, and a limited sampling strategy for therapeutic drug monitoring is explored.Thirty patients (212 samples) were included population analysis. A was developed using Bayesian estimation, multiple linear regression modified integral equations. Non-linear mixed-effects models Phoenix NLME software.A two-compartment model used to describe...
Cai C‐j, Lu M‐q, Chen Y‐h, Zhao H, Li M‐r, G‐h. Clinical study on prevention of HBV re‐infection by entecavir after liver transplantation. Clin Transplant 2011 DOI: 10.1111/j.1399‐0012.2011.01448.x. © John Wiley & Sons A/S. Abstract: Purpose: This aims to evaluate the effects lamivudine (LAM) and (ETV) in preventing hepatitis B virus (HBV) transplantation (LT). Methods: A retrospective matched case‐control method was used this study. From June 2005 May 2007, patients who received LAM...
Regulatory mechanisms of microRNAs (miRNAs) in the development intestinal sepsis are unclear. This study investigated role rno-miR-146b-5p sepsis-induced injury. A rat model was created using cecal ligation and puncture method. The expression profiles miRNA mRNA rats were examined sequencing; rno-miR-146b selected for further investigation. mimics inhibitors transfected into IEC-6 cells then with or without lipopolysaccharide (LPS) treatment, expressions Kruppel-like factor 4 (Klf4) Cyclin...
To characterize the pharmacokinetics (PK) of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction.Patients dysfunction intensive care unit (ICU) were included prospectively. The Child-Pugh score was used to categorize degree dysfunction. initial VRC dosing regimen comprised a loading dose 300 mg every 12 h for first 24 h, followed by 200 h. PK curves (PK curve 1) drawn within one interval 17 patients; second 2) after minimum seven doses patients. parameters...
Introduction Sepsis-induced cardiomyopathy is a common complication of sepsis and associated with higher mortality. To date, effective diagnostic management strategies are still lacking. Recent studies suggest that ferroptosis plays critical role in sepsis-induced inhibitor Ferrostatin-1 (Fer-1) improved cardiac dysfunction survival lipopolysaccharide (LPS) induced endotoxemia. However, the effects Fer-1 early stages cecal ligation puncture (CLP) remains unclear. Our study aims to elucidate...
In this paper, we tackle air quality forecasting by using machine learning approaches to predict the hourly concentration of pollutants (e.g., Ozone, PM2.5 and Sulfur Dioxide). Machine learning, as one most popular techniques, is able efficiently train a model on big data large-scale optimization algorithms. Although there exists some works applying prediction, prior studies are restricted small scale simply standard regression models (linear or non-linear) pollution concentration. work,...
In this study, we aimed to determine whether the pseudogene integrator complex subunit 6 1 (INTS6P1) in plasma could be used as a novel approach screen for and detect hepatocellular carcinoma (HCC). We explored clinical role of INTS6P1: First, expression level INTS6P1 was measured cohort 33 HCC tissue samples adjacent normal liver tissue, next, detected culture medium tumor cells cellular experiment, last, diagnostic performance examined an independent 100 people. The remarkably...
Abstract Study Objectives This study aimed to establish a population pharmacokinetic (PPK) model of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction and explore the optimal dosing strategies specific clinical scenarios for invasive fungal infections (IFIs) caused by common Aspergillus Candida species. Design Prospective pharmacokinetics study. Setting The intensive care unit tertiary‐care medical center. Patients A total 297 plasma VRC concentrations from 26...
During conventional liver transplantation (CLT), ischaemia-reperfusion injury (IRI) is inevitable and associated with complications such as early allograft dysfunction (EAD), primary non-function ischaemic-type biliary lesions. We have established a novel procedure called ischaemia-free (IFLT). The results from pilot study suggest that IFLT might prevent IRI yield better transplant outcomes than CLT. purpose of this was to further assess the efficacy safety versus CLT in patients end-stage...
The pharmacokinetics (PK) of several drugs including antimicrobials might be highly altered during extracorporeal membrane oxygenation (ECMO) therapy. We present the change voriconazole (VRC) PK ECMO in a critically ill patient who received intravenous VRC at maintenance dose 200 mg every 12 h for empirical antifungal Two profiles were drawn before and after initiation Though trough levels (both C0 C12) with slightly lower than that without (12.58 12.84 vs. 14.02 μg/mL), peak area under...
Data on the distribution of voriconazole (VRC) in human peritoneal cavity are sparse. This prospective study aimed to describe pharmacokinetics intravenous VRC fluid critically ill patients. A total 19 patients were included. Individual pharmacokinetic curves, drawn after single (first dose day 1) and multiple (steady-state) doses, displayed a slower rise lower fluctuation concentrations than plasma. Good but variable penetration into was observed, median (range) fluid/plasma ratios area...
Introduction: Sepsis is one of the leading causes human mortality. There a paucity clinical trials informing specific questions faced by sepsis. The ClinicalTrials.gov registry offers an opportunity to evaluate in Here we analyze 25 years sepsis trial research. Methods: We examined interventional registered with from 1995–2020, focusing on study conditions and interventions identify sepsis-related trials. Relevance ID was manually confirmed for each programmatically identified trial. were...