A5101667757- Total Knee Arthroplasty Outcomes
- Alzheimer's disease research and treatments
- Venous Thromboembolism Diagnosis and Management
- Orthopaedic implants and arthroplasty
- Immune cells in cancer
- Immune Cell Function and Interaction
- Knee injuries and reconstruction techniques
- Acute Myocardial Infarction Research
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Retinoids in leukemia and cellular processes
- Ginkgo biloba and Cashew Applications
- Glioma Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Liver Disease Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Advanced X-ray and CT Imaging
- Vascular Procedures and Complications
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Antioxidant Activity and Oxidative Stress
- Pharmacological Effects of Natural Compounds
- Berberine and alkaloids research
- Anesthesia and Sedative Agents
Third Hospital of Hebei Medical University
2017-2025
Hebei Medical University
2017-2025
Sun Yat-sen University
2015-2024
Sun Yat-sen Memorial Hospital
2017-2024
Third Affiliated Hospital of Sun Yat-sen University
2023
Xiangya Hospital Central South University
2021
Central South University
2019-2021
Second Xiangya Hospital of Central South University
2019-2021
Zhongshan Hospital
2021
Guilin Medical University
2020
Endothelin-1 (ET1) is dysregulated in pulmonary hypertension (PH). It may be important the pathobiology of congenital diaphragmatic hernia (CDH).We hypothesized that ET1 levels first month would higher infants with CDH who subsequently expired or were discharged on oxygen (poor outcome). We further associated concurrent severity PH.We sampled plasma at 24 to 48 hours, and 1, 2, 4 weeks age 40 prospectively enrolled newborns CDH. performed echocardiograms estimate artery pressure less than...
Glioblastoma (GBM) is the most common type of malignant tumor central nervous system. The prognosis patients with GBM very poor, a survival time ~15 months. highly heterogeneous and aggressive. Surgical removal intracranial tumors does provide good advantage for as there high rate recurrence. understanding this cancer needs to be strengthened, aim present study was identify gene signatures in uncover their potential mechanisms. expression profiles GSE15824 GSE51062 were downloaded from Gene...
Ovarian cancer (OC) is a frequently lethal gynecologic malignancy, characterized by poor prognosis and high recurrence rate. The immune microenvironment has been implicated in the progression of OC. We landscape primary malignant OC ascites using single-cell bulk transcriptome raw data acquired from Gene Expression Omnibus Cancer Genome Atlas databases. then used CIBERSORT deconvolution algorithm, weighted gene co-expression network analysis, univariate multivariate Cox analyses, LASSO...
A new series of phosphodiesterase-9 (PDE9) inhibitors that contain a scaffold 6-amino-pyrazolopyrimidinone have been discovered by combination structure-based design and computational docking. This procedure significantly saved the load chemical synthesis is an effective method for discovery inhibitors. The best compound 28 has IC(50) 21 nM 3.3 μM, respectively, PDE9 PDE5 about 3 orders magnitude selectivity against other PDE families. crystal structure catalytic domain in complex with...
Oxidative stress (OS) plays an important role in neurodegenerative diseases such as Alzheimer's disease (AD). Lycopene is a pigment with potent antioxidant and anti-tumor effects. However, its potential central nervous system not well-defined. The aim of this study was to investigate the effect lycopene on cell model AD determine underlying mechanisms.M146L double-transfected (human APP gene presenlin-1 gene) Chinese hamster ovary (CHO) line that overexpresses β -amyloid (Aβ) ideal for AD....
Abstract Background One of the most important objectives modern medical education is to empower students become humanistic clinicians. Human anatomy plays a crucial role in this mission by using cadavers cause reflections on death, dying, illness, and practitioners care. The objective study was introduce, describe, evaluate impact ceremony honor body donors ethical attitudes students. Methods We used phenomenological research approach explore understand lived experiences teachers as they...
Abstract Hepatic steatosis is strongly linked to insulin resistance and type 2 diabetes. GPR40 a G protein-coupled receptor mediating free fatty acid-induced secretion thus plays beneficial role in the improvement of However, impact agonist on hepatic still remains be elucidated. In present study, we found that activation by its GW9508 attenuated Liver X (LXR)-induced lipid accumulation. Activation LXR livers C57BL/6 mice fed high-cholesterol diet HepG2 cells stimulated chemical caused...
Endometrial cancer (EC) is a malignant tumor with various histological subtypes and molecular phenotypes. The evaluation of drug resistance important for treatment. Progesterone the major challenge in EC. Knowledge EC development novel therapies. In this study, ten paracancerous tissues were collected to measure expression insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) high-mobility group 1 (HMGA1). AN3CA Ishikawa cells used explore effects IGF2BP3 on levels HMGA1 higher than...
Small molecular inhibitors or drugs targeting specific alterations are widely used in clinic cancer therapy. Despite the success of targeted therapy, development drug resistance remains a challenging problem. Identifying mechanisms for therapy is an area intense investigation, and recent evidence indicates that cellular polyploidy may be involved. Here, we demonstrate cell cycle kinase inhibitor, Oxindole-1 (Ox-1), induces mitotic slippage, causing resistant acute myeloid leukemia (AML)...
The purpose of this study was to alleviate liver disturbance by applying polysaccharides from Dicliptera chinensis (DCP) act on the adenosine monophosphate-activated protein kinase/ nuclear factor erythroid 2-related 2 (AMPK/ Nrf2) oxidative stress pathway and Toll-like receptor 4 (TLR-4)/ kappa-B (NF-κB) inflammatory establish an in vivo model using male C57BL/6J TLR-4 knockout (-/- ) mice. For this, we evaluated expression levels SREBP-1 Nrf2 after silencing AMPK siRNA technology. Our...
The incidence of gliomas is increasing. Although great progress in glioma treatment has been made, the clinical outcome remains unsatisfactory. Chemokine (C-C motif) ligand 2 (CCL2) plays a key role different types cancers, including glioma. However, function CCL2 chemoresistance not fully understood. In current study, was significantly upregulated More importantly, and CCR2 were temozolomide (TMZ)-resistant TMZ-resistant malignant glioblastoma cells (U251/TMZ) had higher expressions level...
Discoid lateral meniscus (DLM) is more prone to injury than a normally shaped meniscus. No study has compared the gene expression and cell heterogeneity between discoid normal menisci. We aimed identify specific clusters their marker genes in meniscus, thereby providing theoretical basis for treatment etiology of DLM. ScRNA-seq was used DLM osteoarthritis (OAM) cells subsets signatures. Pseudo-time analysis immunohistochemical staining were investigate temporal spatial distribution...
<title>Abstract</title> Plasma membrane integrity is vital not only for cell survival but also nearly all aspects of functioning. Mechanical stress can cause plasma damage, it known whether there are large molecules (proteins) that control integrity. Here we constructed a 384-well cellular stretch system delivers precise, reproducible mechanical strain to adherent cells. Using the system, screened 10,843 siRNAs targeting 2,726 multi-pass transmembrane proteins stretch-induced permeability...
Abstract Aim Early predictive markers of venous thromboembolism (VTE) after total hip arthroplasty (THA)/total knee (TKA) remain unclear. Our study identified early for VTE THA/TKA. Methods A single-institution retrospective review was conducted between May 2020 and April 2022 ( n = 256). All patients underwent Doppler ultrasounds exam in preoperation seventh day surgery. Deep vein thrombosis (DVT) defined by ultrasound the lower extremities, which revealed thrombosis. Thrombin-antithrombin...