A5082091746- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Organ Donation and Transplantation
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Hepatitis C virus research
- Liver physiology and pathology
- Smart Grid and Power Systems
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Power Systems and Technologies
- Power System Reliability and Maintenance
- Medical Research and Treatments
- Polyomavirus and related diseases
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Power Systems and Renewable Energy
- Electric Vehicles and Infrastructure
- Circular RNAs in diseases
Guangxi University of Chinese Medicine
2025
Soochow University
2024-2025
First Affiliated Hospital of Soochow University
2024-2025
Peking University
2024
The First Affiliated Hospital, Sun Yat-sen University
2014-2024
Sun Yat-sen University
2014-2024
Southern Medical University
2022-2024
Guangdong Academy of Medical Sciences
2022-2024
Guangdong Provincial People's Hospital
2022-2024
Shantou University
2022-2024
Ischemia-reperfusion injury (IRI) has thus far been considered as an inevitable component of organ transplantation, compromising outcomes, and limiting availability. Ischemia-free transplantation is a novel approach designed to avoid IRI, with the potential improve outcomes.
Ischemia and reperfusion injury (IRI) is an inevitable event in conventional organ transplant procedure associated with significant mortality morbidity post-transplantation. We hypothesize that IRI avoidable if the blood supply for not stopped, thus resulting optimal outcomes. Here we described first case of a novel called ischemia-free transplantation (IFOT) patients end-stage liver disease. The graft severe macrovesicular steatosis was donated from 25-year-old man. recipient 51-year-old...
Inadequate liver regeneration (LR) is still an unsolved problem in major resection and small-for-size syndrome post-living donor transplantation. A number of microRNAs have been shown to play important roles cell proliferation. Herein, we investigated the role miR-26a as a pivotal regulator hepatocyte proliferation LR.Adult male C57BL/6J mice, undergoing 70% partial hepatectomy (PH), were treated with Ad5-anti-miR-26a-LUC or Ad5-miR-26a-LUC Ad5-LUC vector via portal vein. The animals...
The in vivo roles for even the most intensely studied microRNAs remain poorly defined. Here, analysis of mouse models revealed that let-7, a large and ancient microRNA family, performs tumor suppressive at expense regeneration. Too little or too much let-7 resulted compromised protection against cancer tissue damage, respectively. Modest overexpression abrogated MYC-driven liver by antagonizing multiple sensitive oncogenes. However, same level blocked regeneration, while deletion enhanced...
Apoptosis resistance in human hepatocellular carcinoma (HCC) is a significant factor carcinogenesis. Therefore, understanding the molecular mechanisms involved apoptosis crucial for developing anticancer therapies. Importantly, small non-coding microRNAs (miRNAs) have been reported as key biomarkers detecting tumour onset and progression. In present study, we demonstrate that miR-1180 upregulated HCC. Ectopic expression of has an anti-apoptotic effect HCC, while inhibition increases cell...
Hepatectomy is an effective surgical method for the treatment of liver diseases, but intraoperative bleeding and postoperative function recovery are still key issues. This study aims to develop a composite hydrogel dressing with excellent hemostatic properties, biocompatibility, ability promote cell regeneration. The modified gelatin matrix (GelMA, 10%) was mixed equal volumes sodium alginate-dopamine (Alg-DA) at concentrations 0.5%, 1%, 2%. Then cross-linking agent (0.1%) added prepare...
Patients with advanced hepatocellular carcinoma (HCC) continue to have a dismal prognosis. Potential biomarkers determine prognosis and select targeted therapies are urgently needed for patients HCC. This study aimed elucidate the role of UCK2 in HCC tumor progression. We performed screen public databases identify functional genes associated tumorigenesis, progression, outcome. identified uridine-cytidine kinase 2 (UCK2) as gene interest further study. promoting aggressiveness was...
Fatty liver disease is one of the leading causes chronic damage in western countries. Approximately 25% adults United States have fatty livers absence excessive alcohol consumption, a condition termed nonalcoholic (NAFLD). Little known about prevalence and genetic background NAFLD or factors that determine its development. In this study, we used Gene-Cloud Biotechnology Information bioinformatics platform to carry out comprehensive analysis identifying differentially expressed genes (DEGs),...
Background: Liver transplantation (LT) is an effective option for hepatocellular carcinoma (HCC) and end-stage liver cirrhosis. However, organ shortage tumor recurrence are the main obstacles limiting its popularization application in HCC patients. Testing circulating cells (CTCs) would be a valuable strategy to predict metastasis of after LT. Various CTCs detection methods have different advantages disadvantages. This study aims investigate predictive value testing based on...
Background: B7-H3 (or CD276) represents an important costimulatory molecule expressed in many malignant solid tumors, including colorectal cancer (CRC). The receptor of is not known, and the intracellular function remains obscure. Herein, we report that upregulated epidermal growth factor heparin-binding (HB-EGF), likely by regulating hypoxia-inducible 1α (HIF-1α) thereby promoting progression CRC. Methods: Lentiviral transfection was performed on CRC cells to establish stable low-B7-H3...
Background: Obg-like ATPase 1 (OLA1) has been found to have a dual role in cancers.However, the relationship between OLA1 and hepatocellular carcinoma (HCC) remains unclear.Results: High expression of HCC was detected public datasets clinical samples, correlated with poor prognosis.Downregulation significantly inhibited proliferation, migration, invasion tumorigenicity cells.Mechanistically, GSEA showed that might promote tumor progression by regulating cell cycle apoptosis.In addition,...
Gastric precancerous lesions represent a critical transitional stage, marking the final opportunity for intervention before onset of gastric cancer. Drawing parallels between toxicity and deficiency theory Zhuang medicine pathogenesis lesions, it is postulated that serves as pivotal extrinsic factor in their development, while constitutes an intrinsic underlying cause. In addressing managing emphasizes importance regulating vital energy (qi), detoxify, replenishing deficiencies, harmonizing...
Recent findings reveal that the precursors of exhausted CD8+ T (CD8+ Tpex) cells possess stem-like signatures in tumor immunity, which originate from draining lymph node (TdLN)-derived tumor-specific memory TTSM) cells. Both these subsets can be collectively referred to as cells, demonstrate robust self-renewal ability and proliferate differentiate into transitory effector-like (Texint). There are reports chemotherapeutic drugs promote antitumor immune responses patients by increasing number...
BACKGROUND Calciphylaxis, also called calcific uremic arteriolopathy, is characterized by microvascular calcification and occlusion, which commonly seen in patients with end-stage renal disease (ESRD). Although several studies have demonstrated an association of calciphylaxis ESRD, reports linking to LT (LT) are scarce. This report presents a rare case patient who underwent LT, leading occlusion hyperbilirubinemia. CASE SUMMARY A 34-year-old man presented 7-day history jaundice severe...
// Anli Yang 1, * , Weiqiang Ju Xiaopeng Yuan Ming Han 1 Xiaoping Wang Zhiyong Guo Xiaoli Wei 2 Dongping Xiaofeng Zhu Linwei Wu and Xiaoshun He Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China Department Medical Oncology, University Cancer State Key Laboratory Oncology in South China, Collaborative Innovation Center for Medicine, 510060, These authors have contributed equally to this work Correspondence to: Wu, email: lw97002@163.com...