A5054519859- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Neurological Complications and Syndromes
- Renal and Vascular Pathologies
- Hepatitis C virus research
- Dementia and Cognitive Impairment Research
- Blood donation and transfusion practices
- Liver Disease Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Nutrition and Health in Aging
- Healthcare Policy and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Patient-Provider Communication in Healthcare
- Frailty in Older Adults
- Vascular Tumors and Angiosarcomas
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Epilepsy research and treatment
- Cancer-related cognitive impairment studies
- SARS-CoV-2 and COVID-19 Research
Johns Hopkins Medicine
2017-2025
Johns Hopkins University
2017-2025
Johns Hopkins Hospital
2017-2025
Universitätsklinikum Würzburg
2023-2024
University of Würzburg
2023
University of Baltimore
2017-2018
National Institute of Diabetes and Digestive and Kidney Diseases
2018
Institute of Aging
2018
Sarcomas represent a heterogeneous group of tumors, and there is lack data describing contemporary changes in patterns care. We evaluated the epidemiology sarcomas over 12 recent years.The Surveillance, Epidemiology End Results (SEER) database was queried for sarcoma cases from 2002-2014. Patient, tumor treatment factors, trends time were studied overall by subtype. Univariable multivariable logistic regression models 5-year survival cause-specific mortality (CSM) summarized.There 78,527...
The Kidney Allocation System fundamentally altered kidney allocation, causing a substantial increase in regional and national sharing that we hypothesized might impact geographic disparities. We measured disparity deceased donor transplant (DDKT) rate under KAS (6/1/2015-12/1/2016), compared with pre-KAS (6/1/2013-12/3/2014). modeled DSA-level DDKT rates multilevel Poisson regression, adjusting for allocation factors KAS. Using the model calculated novel, improved metric of disparity: median...
Historically, exception points for hepatocellular carcinoma (HCC) led to higher transplant rates and lower waitlist mortality HCC candidates compared non-HCC candidates. As of October 2015, must wait 6 months after initial application obtain points; the impact this policy remains unstudied. Using 2013-2017 SRTR data, we identified 39 350 adult, first-time, active deceased donor liver (DDLT) mortality/dropout versus before (October 8, 2013-October 7, prepolicy) 2015-October 2017, postpolicy)...
Background. Cognitive impairment is common in patients with end-stage renal disease and associated poor outcomes on dialysis. We hypothesized that cognitive might be an increased risk of all-cause graft loss (ACGL) kidney transplant (KT) recipients. Methods. Using the Modified Mini-Mental State (3MS) examination, we measured global function at KT hospital admission a prospective, 2-center cohort 864 candidates (August 2009 to July 2016). estimated association between pre-KT ACGL using Cox...
Impaired cognition in liver recipients has been studied the immediate post-transplant period but is poorly understood long-term, despite its importance to quality of life. In a single-center cohort transplanted 2010-2022 and >1 years post-transplant, we assessed cognitive performance using telephone-based battery. We compared depression, anxiety, self-reported function by descriptive statistics. Among 120 participants (median age 65, median 7.3 y post-transplant), 25% had...
ABSTRACT Introduction Hepatic epithelioid hemangioendothelioma (HEH) is a rare indication of liver transplant with limited evidence. Methods Adult recipients undergoing first‐time liver‐only from 2002 to 2021 in the United States were identified using UNOS/OPTN database. We compared post‐transplant outcomes receiving for HEH versus other diagnoses. Survival was visualized Kaplan‐Meier curves and log‐rank test multivariable Cox regression. Propensity score matching recipient age, sex, MELD...
Social media platforms are increasingly used in surgery and have shown promise as effective tools to promote deceased donation expand living donor transplantation. There is a growing need understand how social media-driven communication perceived by providers the field of
In our first survey of transplant centers in March 2020, >75% kidney and liver programs were either suspended or operating under restrictions. To safely resume transplantation, we must understand the evolving impact COVID-19 on recipients center-level practices. We therefore conducted a six-week follow-up May 7-15, linked responses to incidence map, with response rate 84%. Suspension live donor transplantation decreased from 72% 30% for kidneys 68% 52% livers. Restrictions/suspension...
Liposarcomas of the spermatic cord, a rare cause an inguinal mass, may closely mimic hernias on clinical examination. However, these tumors require different surgical approach and treatment plan; therefore, intraoperative diagnosis might complicate patient management. We report case 63-year-old man who presented with mobile mass in canal consistent hernia. The was subsequently diagnosed liposarcoma cord successfully treated extensive local resection, including radical orchiectomy en bloc...
Background. Kidney transplant (KT) recipients have numerous risk factors for delirium, including those shared with the general surgical population (eg, age and major surgery) transplant-specific neurotoxic immunosuppression medications). Evidence has linked delirium to long-term dementia in older adults undergoing surgery. We sought characterize associated post-KT delirium. Methods. Using United States Renal Data System datasets, we identified 35 800 adult first-time KT ≥55 y. evaluated...
Thoracoabdominal normothermic regional perfusion (TA-NRP) has recently emerged as a multiorgan procurement technique for donation after circulatory death (DCD) donors, with excellent outcomes thus far.1-4 However, the literature on TA-NRP utilization pediatric DCD donors remains limited. Using United Network Organ Sharing registry, we retrospectively assessed national of kidney and liver recipients who received organs from (<18 y) January 1, 2020, to June 30, 2023. We compared perioperative...
Background. Machine perfusion (MP) for liver transplantation has become more widespread in the United States, but national studies on this growing practice are lacking. We investigated use and outcomes of MP transplantation. Methods. Adult (≥18 y) recipients transplanted between January 1, 2016 September 30, 2023 Network Organ Sharing database were included. used Cox regression to compare 1-y posttransplant recipient survival all-cause graft failure by performed subgroup analyses among...
Abstract Background Frailty is common and associated with poor outcomes among kidney transplant (KT) recipients. While frailty improves in the first 3 months post-KT restored function, longer-term trajectories are likely to plateau/decline due aging other stressors (eg, immunosuppression). We evaluated of physical phenotype (PFP) its components adult patients at 2 centers. Methods PFP were measured admission, 1, 3, 6 months, 1 year, annually thereafter post-KT. used adjusted mixed-effects...
Background. Thoracoabdominal normothermic regional perfusion (TA-NRP) has been increasingly used for donation after circulatory death (DCD) procurements in the United States. We present largest report of outcomes kidney transplants performed using DCD donor grafts perfused with TA-NRP. Methods. Adult between 2020 and 2022 Network Organ Sharing database were included. Donors ≥50 min asystole aortic cross-clamp time which heart was also transplanted considered TA-NRP donors. All other donors...