A5060742079- Long-Term Effects of COVID-19
- Glioma Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- COVID-19 and Mental Health
- Brain Metastases and Treatment
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Cancer-related cognitive impairment studies
- Attention Deficit Hyperactivity Disorder
- Neurobiology of Language and Bilingualism
- Traumatic Brain Injury Research
- Lung Cancer Research Studies
- Biochemical and Molecular Research
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Schizophrenia research and treatment
- Family and Patient Care in Intensive Care Units
- Advanced Neuroimaging Techniques and Applications
- Gout, Hyperuricemia, Uric Acid
- Cognitive Abilities and Testing
- Mental Health and Psychiatry
- Dementia and Cognitive Impairment Research
- Spondyloarthritis Studies and Treatments
- Cancer survivorship and care
- Obsessive-Compulsive Spectrum Disorders
Johns Hopkins Medicine
2014-2025
Johns Hopkins University
2015-2025
Institute of Behavioral Sciences
2018
Neurology, Inc
2018
University of Colombo
2016
Emory University
2014
Johns Hopkins Hospital
2010
Hartford Hospital
2007
Yale University
2007
University of Maryland, Baltimore County
2004
Uric acid (UA) has antioxidant properties yet when elevated is associated with vascular disease and stroke. Further, even high normal UA increased risk of mild cognitive dysfunction in elderly adults.In this cross-sectional, observational study, we examined the relationship between serum aggregate volume white matter hyperintense (WMH) signals observed on proton density T2-weighted brain MR images a community sample 177 adults ages 20 to 92. Using logistic regression, tested whether...
Transcranial direct current stimulation (tDCS) is an emerging neuromodulation therapy that has been experimentally determined to affect a wide range of behaviors and diseases ranging from motor, cognitive, memory processes depression pain syndromes. The effects tDCS may be inhibitory or excitatory, depending on the relative polarities electrodes their proximity different brain structures. This distinction believed relate interaction flow with activation thresholds neural complexes. currents...
Background and Purpose— High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction increased cerebral ischemia as indexed by white matter hyperintensity volumes. We hypothesized that individual differences in hyperintensities mediate the association between UA dysfunction. Methods— One hundred eighty community-dwelling adults aged 20 to 96 years completed neuropsychological testing, laboratory blood studies, a brain MRI scan. Results— Serum was ( P...
The Iowa Gambling Task (IGT) is assumed to measure executive functioning, but this has not been empirically tested by means of both convergent and discriminant validity. We used structural equation modeling (SEM) test whether the IGT an function (EF) task (convergent validity) it related other neuropsychological domains (discriminant validity). Healthy community-dwelling participants (N = 214) completed a comprehensive battery. analyzed conventional metric three alternative metrics based on...
Transcranial direct current stimulation (tDCS) has been shown to enhance verbal productivity, but the finding and extent of enhancement vary across studies. Few attempts replicate positive tDCS findings have reported, suggesting possibility publication bias.We aimed methodology Cattaneo, Pisoni, Papagno (2011, Neuroscience 183:64-70) in a new population sample. We hypothesized that our study anodal would improve fluency production similarly original study.In single-blind, sham-controlled...
White matter hyperintensities (WMH) can compromise cognition in older adults, but differences sampling, WMH measurements, and cognitive assessments contribute to discrepant findings across studies. We examined linear nonlinear effects of volumes on 253 reasonably healthy adults. After adjusting for demographic characteristics total brain volumes, burden was not associated with those aged 20–59. In participants 60 older, models accounted ≥58% the variance performance tests working memory,...
Background: Word retrieval during verbal fluency tasks utilizes both automatic and controlled cognitive processes. A distinction has been made between the generation of clusters switches on tasks. Clusters, or reporting contiguous words within semantic phonemic subcategories, are thought to reflect a relatively processes In contrast, switching from one subcategory another is represent more controlled, effortful form processing. Objective: this single-blind experiment, we investigated whether...
Working memory (WM) often is impaired in autism spectrum disorder (ASD). Such impairment may underlie core deficits cognition and social functioning. Transcranial direct current stimulation (tDCS) has been shown to enhance WM both healthy adults clinical populations, but its efficacy ASD unknown. We predicted that bifrontal tDCS would improve performances of with high-functioning during active compared sham such enhancement generalize an untrained task.Twelve engaged a battery tasks included...
This Viewpoint provides recommendations for assessment of post–COVID-19 cognitive dysfunction to improve understanding the pathophysiology condition and develop appropriate interventions.
Cognitive dysfunction is a common symptom of post-COVID-19 condition (PCC). Few studies have examined rates and predictors cognitive performance validity test (PVT) failure in patients seeking treatment for PCC.
Impaired cognition in liver recipients has been studied the immediate post-transplant period but is poorly understood long-term, despite its importance to quality of life. In a single-center cohort transplanted 2010-2022 and >1 years post-transplant, we assessed cognitive performance using telephone-based battery. We compared depression, anxiety, self-reported function by descriptive statistics. Among 120 participants (median age 65, median 7.3 y post-transplant), 25% had...
Abstract Objectives Socioeconomic (SES) and health status (HS) are rarely considered when normative data calculated. In the present study, for Trail Making Test (TMT) were developed from a large cohort association of sex, age education, as well HS SES, with direct derived TMT scores was explored. Methods Two thousand three hundred sixteen participants [1412 (61%) women; mean age: 47.11 (SD = 11.67) years; education: 14.82 3.39) years] drawn population-based Epirus Health Study. rated on...
Diabetes is associated with dementia in older adults, but it remains unclear whether nondemented adults type 2 diabetes show subtle abnormalities across cognition, neuroanatomy, and everyday functioning. Using the Aging, Brain Imaging, Cognition study sample of 301 community-dwelling, middle-aged we conducted a secondary analysis on 28 participants 150 without diabetes. We analyzed brain magnetic resonance imaging data, cognitive test performance, informant ratings personal instrumental...
This study was conducted in response to calls develop Iowa Gambling Task (IGT) metrics reflecting more homogeneous aspects of decision making, as well add the literature on reliability and validity instrument. The conventional IGT metric, advantageous minus disadvantageous deck selections, compared alternatives which Decks B C or first 40 selections were eliminated. We correlated these alternative with performance other neuropsychological tests 214 healthy adults, we participant subgroups...
Many disorders are characterized by impoverished ideational fluency. Tests of letter word, category and design fluency likely invoke different cognitive processes, but they might depend on overlapping cortical circuits. Despite differences in the tasks used to assess it, we hypothesized that represents a dissociable dimension human cognition.Altogether, 317 healthy adults 280 with medical or psychiatric illnesses completed test battery included three measures Principal component analyses...
<h3>Objective:</h3> We sought to examine brain white matter abnormalities based on MRI in adults with Lesch-Nyhan disease (LND) or an attenuated variant (LNV) of this rare, X-linked neurodevelopmental disorder purine metabolism. <h3>Methods:</h3> In observational study, we compared 21 LND, 17 LNV, and 33 age-, sex-, race-matched healthy controls using voxel-based morphometry analysis covariance identify volume both patient groups. <h3>Results:</h3> Patients classic LND showed larger...