A5076608488- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Cardiac Arrest and Resuscitation
- Tracheal and airway disorders
- Polyomavirus and related diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cystic Fibrosis Research Advances
- Organ and Tissue Transplantation Research
- Cancer Immunotherapy and Biomarkers
- Cardiac Structural Anomalies and Repair
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Aortic Disease and Treatment Approaches
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Organ Donation and Transplantation
- Lung Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Hepatitis C virus research
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
2016-2025
Johns Hopkins Hospital
2018-2024
Twitter (United States)
2024
Stanford Medicine
2022
Cleveland Clinic
2022
Stanford University
2022
University of Baltimore
2022
Sidney Kimmel Comprehensive Cancer Center
2020-2021
Krankenhaus Bethanien
2021
Abstract PD-1 blockade unleashes CD8 T cells 1 , including those specific for mutation-associated neoantigens (MANA), but factors in the tumour microenvironment can inhibit these cell responses. Single-cell transcriptomics have revealed global dysfunction programs tumour-infiltrating lymphocytes (TIL). However, majority of TIL do not recognize antigens 2 and little is known about transcriptional MANA-specific TIL. Here, we identify clones using MANA functional expansion assay 3 neoadjuvant...
Frailty is associated with morbidity and mortality in abdominal organ transplantation but has not been examined lung transplantation.To examine the construct predictive validity of frailty phenotypes transplant candidates.In a multicenter prospective cohort, we measured Fried Phenotype (FFP) Short Physical Performance Battery (SPPB). We evaluated through comparisons conceptually related factors. In nested case-control study frail nonfrail subjects, serum IL-6, tumor necrosis factor receptor...
We conducted the first trial of neoadjuvant PD-1 blockade in resectable non-small cell lung cancer (NSCLC), finding nivolumab monotherapy to be safe and feasible with an encouraging rate pathologic response. Building on these results, promising data for plus ipilimumab (anti-CTLA-4) advanced NSCLC, we expanded our study include arm investigating ipilimumab.Patients stage IB (≥4 cm)-IIIA (American Joint Committee Cancer Tumor Node Metastases seventh edition), histologically confirmed,...
While several studies have observed that solid organ transplant recipients experience diminished antibody responses to SARS-CoV-2 mRNA vaccination, data specific heart and lung (HT/LT) remains sparse.US adult HT LT completed their vaccine series between January 7 April 10, 2021. Reactogencity anti-spike were assessed after a priming dose (D1) booster (D2). Modified Poisson regression with robust variance estimator was used evaluate associations participant characteristics development.Of 134...
Abstract Background To assess the safety and feasibility of imaging brain with a point-of-care (POC) magnetic resonance (MRI) system in patients on extracorporeal membrane oxygenation (ECMO). Early detection acute injury (ABI) is critical improving survival for ECMO support. Methods Patients from single tertiary academic center who underwent head CT (HCT), followed by POC MRI examinations within 24 h following HCT while ECMO. Primary outcomes were feasibility, defined as completion...
ABGarterial blood gas ABI acute brain injury AUC-ROC Conclusions:In the largest study predicting neurological complications with ML in ECMO, longer ECMO duration and higher 24h pump flow were associated non-ECPR ECPR VA-ECMO.
Abstract —Recent studies have identified the presence of macrophages in arterial wall hypertensive animals and suggested that as is case atherosclerosis, macrophage products may be important mediators adaptive response wall. In support this, we previously shown expression monocyte chemoattractant protein-1 upregulated arteries animals. We hypothesized recruitment a critical step pathogenesis hypertension. To obtain insights into this potential mechanism, made use mice deficient CC chemokine...
OBJECTIVES: Stroke is commonly reported in patients receiving venovenous extracorporeal membrane oxygenation, but risk factors are not well described. We sought to determine preextracorporeal oxygenation and on-extracorporeal for both ischemic hemorrhagic strokes with support. DESIGN: Retrospective analysis. SETTING: Data the Extracorporeal Life Support Organization by 366 centers from 2013 2019. PATIENTS: Patients older than 18 years supported a single run of oxygenation. INTERVENTIONS:...
Background: Black heart transplant recipients have higher risk of mortality than White recipients. Better understanding this disparity, including subgroups most affected and timing the highest risk, is necessary to improve care We hypothesize that disparity may be pronounced among young recipients, as barriers like socioeconomic factors particularly salient in a younger population lead early mortality. Methods: studied 22 997 adult using Scientific Registry Transplant Recipients data from...