A5101897843- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Hemodynamic Monitoring and Therapy
- Spinal Fractures and Fixation Techniques
- Central Venous Catheters and Hemodialysis
- Ultrasound in Clinical Applications
- Trauma Management and Diagnosis
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Pleural and Pulmonary Diseases
- Sepsis Diagnosis and Treatment
- Marine Invertebrate Physiology and Ecology
- Streptococcal Infections and Treatments
- Biliary and Gastrointestinal Fistulas
- Spine and Intervertebral Disc Pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Acute Kidney Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Poisoning and overdose treatments
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Digestive system and related health
John Brown University
2023-2024
Brown University
2017-2024
University of Pennsylvania
2023-2024
Johns Hopkins Medicine
2023-2024
Johns Hopkins University
2023-2024
Warren Alpert Foundation
2023
Northeast Normal University
2017
Hospital of the University of Pennsylvania
2012
It is unclear if a low- or high-volume IV fluid resuscitation strategy better for patients with severe sepsis and septic shock. Prospective randomized controlled trial. Two adult acute care hospitals within single academic system. Patients shock admitted from the emergency department to ICU November 2016 February 2018. were randomly assigned restrictive (≤ 60 mL/kg of fluid) usual first 72 hours care. We enrolled 109 patients, whom 55 group 54 group. The received significantly less...
ABGarterial blood gas ABI acute brain injury AUC-ROC Conclusions:In the largest study predicting neurological complications with ML in ECMO, longer ECMO duration and higher 24h pump flow were associated non-ECPR ECPR VA-ECMO.
Abstract DNA repair protein counteracting oxidative promoter lesions may modulate gene expression. Oxidative bases modified by reactive oxygen species (ROS), primarily as 7, 8-dihydro-8-oxo-2′-deoxyguanosine (8-oxoG), which is repaired 8-oxoguanine glycosylase1 (OGG1) during base excision (BER) pathway. Because cellular response to challenge accompanied damage repair, we tested whether the OGG1 compatible with transcription factor binding and We performed electrophoretic mobility shift assay...
Abstract Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested hypothesis that pneumonia‐elicited cytotoxic amyloid tau variants: (1) present circulation during infection; (2) lead to impairment potentiation; and, (3) inhibit potentiation dependent upon tau. Cytotoxic species were recovered from blood hippocampus following pneumonia, they extracorporeal membrane...
Objectives To create a deep learning algorithm capable of video classification, using long short‐term memory (LSTM) network, to analyze collapsibility the inferior vena cava (IVC) predict fluid responsiveness in critically ill patients. Methods We used data set IVC ultrasound (US) videos train LSTM network. The was created from US spontaneously breathing patients undergoing intravenous resuscitation as part 2 prior prospective studies. randomly selected 90% network and 10% test network's...
Objectives: Inferior vena cava collapsibility (cIVC) measured by point-of-care ultrasound (POCUS) has been proposed as a noninvasive means of assessing fluid responsiveness. We aimed to prospectively evaluate the performance 25% cIVC cutoff value detect responsiveness among spontaneously breathing intensive care unit (ICU) patients when assessed with POCUS novice versus expert physician sonologists. Methods: Prospective observational study ICU patients. Fluid was defined >10% increase in...
To determine if machine learning (ML) can predict acute brain injury (ABI) and identify modifiable risk factors for ABI in venoarterial extracorporeal membrane oxygenation (VA-ECMO) patients.
Background: Respiratory variation in carotid artery peak systolic velocity (ΔVpeak) assessed by point-of-care ultrasound (POCUS) has been proposed as a noninvasive means to predict fluid responsiveness. We aimed evaluate the ability of ΔVpeak novice physician sonologists Methods: This study was conducted 2 intensive care units. Spontaneously breathing, nonintubated patients with signs volume depletion were included. Patients atrial fibrillation/flutter, cardiogenic, obstructive or neurogenic...
A common complication of extracorporeal membrane oxygenation (ECMO) is circuit and patient thrombosis, even when systemic anticoagulation utilized. However, there are no evidence-based deep vein thrombosis (DVT) screening recommendations for this population. We sought to describe the prevalence DVT among patients supported with ECMO at our institution where they screened routinely. found that 45% survivors were diagnosed a DVT. The majority these DVTs associated cannulas. conclude in...
Neuroinflammation is closely related to Alzheimer's Disease (AD) pathology, hence supplements with anti-inflammatory property could help attenuate the progression of AD. This study was conducted evaluate potential effects liposome encapsulated thymol (LET), administered orally, in prevention Alzheimer a rat model by mechanisms.
BackgroundVenovenous extracorporeal membrane oxygenation (VV-ECMO) is associated with acute brain injury (ABI), including central nervous system (CNS) ischemia (defined as ischemic stroke or hypoxic-ischemic [HIBI]) and intracranial hemorrhage (ICH). Data on prediction models for neurologic outcomes in VV-ECMO are limited.MethodsWe analyzed adult (age ≥18 years) patients the Extracorporeal Life Support Organization (ELSO) Registry (2009-2021) from 676 centers. ABI was defined CNS ischemia,...
Abstract Background: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is associated with acute brain injury (ABI), including central nervous system (CNS) ischemia (defined as ischemic stroke or hypoxic-ischemic injury) and intracranial hemorrhage (ICH). There limited data on prediction models for ABI neurological outcomes in VV-ECMO. Research Question: Can machine learning (ML) accurately predict identify modifiable factors of VV-ECMO? Study Design Methods: We analyzed adult (≥18...