A5069966002- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Liver Disease and Transplantation
- Vascular Anomalies and Treatments
- Heart Failure Treatment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ultrasound in Clinical Applications
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Renin-Angiotensin System Studies
- Cardiovascular and Diving-Related Complications
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Studies on Chitinases and Chitosanases
- Congenital Heart Disease Studies
- Extracellular vesicles in disease
- MicroRNA in disease regulation
Brown University
2016-2025
Providence College
2015-2024
University of Pennsylvania
2002-2024
John Brown University
2023-2024
Johns Hopkins Medicine
2023-2024
Johns Hopkins University
2023-2024
La Jolla Alcohol Research
2022-2023
Parks Victoria
2022-2023
Nephrologisches Zentrum Goettingen
2022-2023
RELX Group (United States)
2022-2023
Section:ChooseTop of pageAbstract <<ContentsOverviewIntroductionMethodsDefinition, Development, ...Topic Domain 1: Optimizin...Topic 2: Analyzing...Topic 3: Decipheri...ConclusionsReferencesCITING ARTICLES
Extracellular vesicles (EVs) from mice with monocrotaline (MCT)-induced pulmonary hypertension (PH) induce PH in healthy mice, and the exosomes (EXO) fraction of EVs mesenchymal stem cells (MSCs) can blunt development hypoxic PH. We sought to determine whether EXO is responsible for modulating vascular responses differences EXO-miR content explains differential effects EXOs MSCs MCT-PH.Plasma, lung MCT-PH, control were divided into (exosome), microvesicle (MV) fractions injected mice. EXO,...
Sex hormones have effects on the left ventricle, but hormonal influences right ventricle (RV) are unknown.We hypothesized that sex would be associated with RV morphology in a large cohort free of cardiovascular disease.Sex were measured by immunoassay and ejection fraction (RVEF), stroke volume (RVSV), mass, end-diastolic volume, end-systolic (RVESV) cardiac magnetic resonance imaging 1,957 men 1,738 postmenopausal women. The relationship between each hormone parameter was assessed...
Basic research implicates alveolar endothelial cell apoptosis in the pathogenesis of chronic obstructive pulmonary disease (COPD) and emphysema. However, information on microparticles (EMPs) mild COPD emphysema is lacking. We hypothesized that levels CD31(+) EMPs phenotypic for would be elevated associated with percent computed tomography (CT). Associations microvascular blood flow (PMBF), diffusing capacity, hyperinflation were also examined. The Multi-Ethnic Study Atherosclerosis recruited...
Abstract Patients with severe COVID‐19 disease have been characterized as having the acute respiratory distress syndrome (ARDS). Critically ill patients relatively well‐preserved lung mechanics despite gas exchange abnormalities, a feature not consistent classical ARDS but more pulmonary vascular disease. Many also demonstrate markedly abnormal coagulation, elevated d ‐dimers and higher rates of venous thromboembolism. We present four cases pneumonia failure shock, evidence dead‐space...
Rationale: Recent studies have focused on the role of female sex and estradiol (E2) in pulmonary arterial hypertension (PAH), but it is not known whether hormones are risk factors for PAH men.Objectives: We performed a case-control study to determine hormone levels (E2, dehydroepiandrosterone-sulfate [DHEA-S], testosterone) associated with men.Methods: Plasma men idiopathic, heritable, or connective tissue disease–associated were compared those from age- body mass index–matched without...
Female sex is a risk factor for pulmonary arterial hypertension (PAH), yet females have better survival than males. We sought to determine if was associated with baseline haemodynamics in subjects PAH, and whether age modified these relationships. conducted pooled analysis from 11 randomised trials submitted the US Food Drug Administration. The study sample included 1211 idiopathic 25% of whom were males, 489 connective tissue disease-associated 13% After multivariable adjustment, right...
Rationale: The aromatase inhibitor anastrozole blocks the conversion of androgens to estrogen and blunts pulmonary hypertension in animals, but its efficacy treating patients with arterial (PAH) is unknown.Objectives: We aimed determine safety PAH.Methods: performed a randomized, double-blind, placebo-controlled trial PAH who received background therapy at two centers.Measurements Main Results: A total 18 were randomized 1 mg or matching placebo 2:1 ratio. co–primary outcomes percent change...
Female sex is a significant risk factor for pulmonary arterial hypertension (PAH), yet males with PAH have worse survival - phenomenon referred to as the "sex paradox" in PAH. All adult patients Pulmonary Hypertension Association Registry (PHAR) congruent and gender were included. Baseline differences demographics, hemodynamics, functional parameters, quality of life assessed by sex. Kaplan-Meier analysis was used evaluate Mediation conducted Cox proportional hazards regression comparing...
Rationale: Inhibition of aromatase with anastrozole reduces pulmonary hypertension in experimental models. Objectives: We aimed to determine whether improved the 6-minute-walk distance (6MWD) at 6 months arterial (PAH). Methods: performed a randomized, double-blind, placebo-controlled phase II clinical trial subjects PAH seven centers. Eighty-four postmenopausal women and men were randomized 1:1 ratio receive 1 mg or placebo by mouth daily, stratified sex using permuted blocks variable...
ABGarterial blood gas ABI acute brain injury AUC-ROC Conclusions:In the largest study predicting neurological complications with ML in ECMO, longer ECMO duration and higher 24h pump flow were associated non-ECPR ECPR VA-ECMO.
Mesenchymal stem cell extracellular vesicles attenuate pulmonary hypertension, but their ability to reverse established disease in larger animal models and the duration mechanism(s) of effect are unknown. We sought determine efficacy mechanism mesenchymal cells’ attenuating hypertension rats with Sugen/hypoxia-induced hypertension. Male were treated or an equal volume saline vehicle by tail vein injection before after subcutaneous Sugen 5416 exposure 3 weeks hypoxia. Pulmonary was assessed...
High oestradiol (E2) and low dehydroepiandrosterone-sulfate (DHEA-S) levels are risk factors for pulmonary arterial hypertension (PAH) in men, but whether sex hormones related to PAH women is unknown. Post-menopausal aged ≥55 years with were matched by age body mass index without cardiovascular disease. Plasma hormone measured immunoassay. Lower of DHEA-S (p<0.001) higher E2 (p=0.02) associated PAH. In cases (n=112), lower worse haemodynamics (all p<0.01) more right ventricular...
Rationale: Patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic (CTEPH) typically undergo frequent clinical evaluation. The incidence outcomes of coronavirus disease (COVID-19) its impact on routine management for patients vascular is currently unknown.Objectives: To assess the cumulative recognized COVID-19 PAH/CTEPH followed at accredited centers, to evaluate pandemic's clinic operations these centers.Methods: A survey was e-mailed program directors centers by...
Abstract Aims Pulmonary arterial hypertension (PAH) is a fatal disease without cure. Previously, we found that transcription factor RUNX1-dependent haematopoietic transformation of endothelial progenitor cells may contribute to the pathogenesis PAH. However, therapeutic potential RUNX1 inhibition reverse established PAH remains unknown. In current study, aimed determine whether was sufficient Sugen/hypoxia (SuHx)-induced pulmonary (PH) in rats. We also demonstrate possible mechanisms...