Pawan Faris
A5062656087- Ion Channels and Receptors
- Calcium signaling and nucleotide metabolism
- Global Maternal and Child Health
- Photoreceptor and optogenetics research
- Climate Change and Health Impacts
- Global Health Care Issues
- Cardiovascular Effects of Exercise
- Neuroscience and Neuropharmacology Research
- Global Public Health Policies and Epidemiology
- Child Nutrition and Water Access
- Health disparities and outcomes
- Global Cancer Incidence and Screening
- Injury Epidemiology and Prevention
- Neurobiology and Insect Physiology Research
- Nitric Oxide and Endothelin Effects
- Trauma and Emergency Care Studies
- Colorectal Cancer Screening and Detection
- Energy and Environment Impacts
- Obesity, Physical Activity, Diet
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Biochemical Analysis and Sensing Techniques
- Adenosine and Purinergic Signaling
- Cardiac electrophysiology and arrhythmias
- Angiogenesis and VEGF in Cancer
University of Pavia
2018-2024
Salahaddin University-Erbil
2018-2024
Cihan University-Erbil
2020-2024
University of Baghdad
2014-2024
University of Karbala
2024
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2023
American University of Beirut
2022
Delhi Technological University
2022
University of Washington
2021
Institute for Health Metrics and Evaluation
2021
Oesophageal cancer is a common and often fatal that has two main histological subtypes: oesophageal squamous cell carcinoma adenocarcinoma. Updated statistics on the incidence mortality of cancer, disability-adjusted life-years (DALYs) caused by disease, can assist policy makers in allocating resources for prevention, treatment, care cancer. We report latest estimates these 195 countries territories between 1990 2017, age, sex, Socio-demographic Index (SDI), using data from Global Burden...
Acute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide comprehensive assessment of the levels trends global burden that could help guide introduction, continuation, ongoing development vaccines treatment programmes.
Air pollution is the sixth highest risk factor for attributable disability-adjusted life-years (DALYs) in North Africa and Middle East, but relative importance of different subtypes air any potential differences their health effects by population demographics or country-level socioeconomic factors have not been fully explored. The objective this study was to investigate effect high ambient particulate matter less than 2·5 μm size (PM) ozone on disease burden, mortality, life expectancy 21...
Schizophrenia (SZ) is a complex neuropsychiatric disorder associated with severe cognitive dysfunction. Although research has mainly focused on forebrain abnormalities, emerging results support the involvement of cerebellum in SZ physiopathology, particularly Cognitive Impairment Associated (CIAS). Besides its role motor learning and control, implicated cognition emotion. Recent suggests that structural functional changes are linked to deficits various domains including attention, working...
Abstract Basal forebrain neurons control cerebral blood flow (CBF) by releasing acetylcholine (Ach), which binds to endothelial muscarinic receptors induce nitric (NO) release and vasodilation in intraparenchymal arterioles. Nevertheless, the mechanism whereby Ach stimulates human brain microvascular cells produce NO is still unknown. Herein, we sought assess whether production a Ca 2+ ‐dependent manner hCMEC/D3 cells, widespread model of cells. induced dose‐dependent increase intracellular...
Nicotinic acid adenine dinucleotide phosphate (NAADP) gates two-pore channels 1 and 2 (TPC1 TPC2) to elicit endo-lysosomal (EL) Ca2+ release. NAADP-induced EL signals may be amplified by the endoplasmic reticulum (ER) through Ca2+-induced release mechanism (CICR). Herein, we aimed at assessing for first time role of signaling in primary cultures human metastatic colorectal carcinoma (mCRC) exploiting imaging molecular biology techniques. The lysosomotropic agent, Gly-Phe β-naphthylamide...
Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is third cause of malignancy-associated mortality. Distant metastases to liver lungs are main drivers CRC-dependent death. Pro-oxidant therapies, which halt disease progression by exacerbating oxidative stress, represent an antitumour strategy that currently exploited chemotherapy ionizing radiation. A more selective therapeutically exploit reactive oxygen species (ROS) signaling would consist in targeting a...
Hydrogen sulfide (H2S) is an endogenous gaseous molecule present in all living organisms that has been traditionally studied for its toxicity. Interestingly, increased understanding of H2S effects organ physiology recently shown relevance as a signalling molecule, with potentially important implications variety clinical disorders, including cancer. primarily produced mammalian cells under various enzymatic pathways are target intense research biological mechanisms, and therapeutic H2S....
Emerging evidence hints in favor of a life-threatening link between severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and the cardiovascular system. SARS-CoV-2 may result dramatic complications, whereas severity COronaVIrus Disease 2019 (COVID-19) incidence fatalities tend to increase patients with pre-existing complications. is internalized into host cells by endocytosis then escape endolysosomal system via endosomes. Two-pore channels drive trafficking through release Ca 2+...
Numerous studies recently showed that the inhibitory neurotransmitter, γ-aminobutyric acid (GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by activating ionotropic GABAA receptors on cerebrovascular endothelial cells, whereas role of metabotropic GABAB is still unknown. Preliminary evidence receptor stimulation induce an increase in Ca2+ levels, but underlying signaling pathway remains to be fully unraveled. In present investigation, we found GABA evoked a...
// Estella Zuccolo 1, * , Umberto Laforenza 2, Federica Ferulli 3, Giorgia Pellavio 2 Scarpellino 1 Matteo Tanzi 3 Ilaria Turin Pawan Faris 4 Angela Lucariello 5 Marcello Maestri 6 Dlzar Ali Kheder 7 Germano Guerra Paolo Pedrazzoli 8 Daniela Montagna 9, ** and Francesco Moccia Department of Biology Biotechnology "Lazzaro Spallanzani", University Pavia, Italy Molecular Medicine, Laboratory Immunology Transplantation, Foundation IRCCS Policlinico San Matteo, Biology, College Science,...
It has long been known that the conditionally essential polyunsaturated arachidonic acid (AA) regulates cerebral blood flow (CBF) through its metabolites prostaglandin E2 and epoxyeicosatrienoic acid, which act on vascular smooth muscle cells pericytes to vasorelax microvessels. However, AA may also elicit endothelial nitric oxide (NO) release an increase in intracellular Ca2+ concentration ([Ca2+]i). Herein, we adopted NO imaging, combined with immunoblotting, assess whether induces signals...
The neuromodulator histamine is able to vasorelax in human cerebral, meningeal and temporal arteries via endothelial 1 receptors (H1 Rs) which result the downstream production of nitric oxide (NO), most powerful vasodilator transmitter brain. Although Ca 2+ signals drive histamine-induced NO release throughout peripheral circulation, mechanism by evokes cerebrovascular cells still unknown. Herein, we exploited cerebral microvascular cell line, hCMEC/D3, assess role intracellular signaling...