A5091093273- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Calcium signaling and nucleotide metabolism
- Photoreceptor and optogenetics research
- Ion Channels and Receptors
- Signaling Pathways in Disease
- Ion channel regulation and function
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Cancer Treatment and Pharmacology
- Prion Diseases and Protein Misfolding
- Medicinal Plants and Neuroprotection
- Adenosine and Purinergic Signaling
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Cholinesterase and Neurodegenerative Diseases
- Hearing, Cochlea, Tinnitus, Genetics
- bioluminescence and chemiluminescence research
- Photosynthetic Processes and Mechanisms
- Trace Elements in Health
- Vestibular and auditory disorders
- Colorectal Cancer Treatments and Studies
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2016-2025
Policlinico San Matteo Fondazione
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Birmingham Women’s and Children’s NHS Foundation Trust
2020
University of Turin
2016
Veneto Institute of Molecular Medicine
2007-2010
Royal National Throat Nose and Ear Hospital
1991-2009
University of Padua
2004-2008
Stazione Zoologica Anton Dohrn
2001-2006
Gray's Inn
1995
Research Article10 November 2010Open Access Mitochondrial fission and cristae disruption increase the response of cell models Huntington's disease to apoptotic stimuli Veronica Costa Department Cell Physiology Medicine, University Geneva, Switzerland Dulbecco-Telethon Institute, Rome, Italy Venetian Institute Molecular Padova, Search for more papers by this author Marta Giacomello Roman Hudec Raffaele Lopreiato Gennady Ermak Ethel Percy Andrus Gerontology Center, Davis School Gerontology,...
Dysfunctions of Ca2+ homeostasis and mitochondria have been studied in immortalized striatal cells from a commonly used Huntington disease mouse model. Transcriptional changes the components phosphatidylinositol cycle receptors for myo-inositol trisphosphate-linked agonists found striatum parent mouse. The overall result is to delay trisphosphate production decrease basal mutant cells. When tested directly, behave nearly normally, but are unable handle large loads. This appears be due...
The amyloid hypothesis of Alzheimer's disease (AD) suggests that soluble β (Aβ) is an initiator a cascade events eventually leading to neurodegeneration. Recently, we reported Aβ deranged Ca(2+) homeostasis specifically in hippocampal astrocytes by targeting key elements signaling, such as mGluR5 and IP3 R1. In the present study, dissect signaling which deregulates glial : (i) 100 nM leads increase cytosolic calcium after 4-6 h treatment; (ii) increased 24 (iii) this blocked inhibitors...
Endothelial progenitor cells (EPCs) may be recruited from bone marrow to sustain tumor vascularisation and promote the metastatic switch. Understanding molecular mechanisms driving EPC proliferation tubulogenesis could outline novel targets for alternative anti-angiogenic treatments. Store-operated Ca(2+) entry (SOCE), which is activated by a depletion of intracellular pool, regulates growth human EPCs, where mediated interaction between endoplasmic reticulum Ca(2+)-sensor, Stim1,...
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Ca2+ enters the stereocilia of hair cells through mechanoelectrical transduction channels opened by deflection bundle and is exported back to endolymph an unusual splicing isoform (w/a) plasma-membrane calcium-pump 2 (PMCA2). Ablation or missense mutations pump cause deafness, as described for G283S mutation in deafwaddler (dfw) mouse. A deafness-inducing PMCA2 (G293S) has been identified a human family. The family also was screened cadherin 23, which accentuated hearing loss previously with...
The entorhinal–hippocampal circuit is severely affected in Alzheimer's disease (AD). Here, we demonstrate that amyloid-β (Aβ) differentially affects primary cultured astrocytes derived from the entorhinal cortex (EC) and hippocampus non-transgenic controls 3xTg-AD transgenic mice. Exposure to 100 nM of Aβ resulted increased expression metabotropic glutamate receptor type 5 (mGluR5) its downstream InsP3 1 (InsP3R1) hippocampal but not EC astrocytes. Amplitudes Ca2+ responses an mGluR5...
Light and semiconducting polymers induce angiogenesis in vitro.
Abstract The pathogenesis of Alzheimer’s disease (AD), a slowly-developing age-related neurodegenerative disorder, is result the action multiple factors including deregulation Ca 2+ homeostasis, mitochondrial dysfunction, and dysproteostasis. Interaction these in astrocytes, principal homeostatic cells central nervous system, still poorly understood. Here we report that immortalized hippocampal astrocytes from 3xTg-AD mice (3Tg-iAstro cells) bioenergetics impaired, reduced glycolysis oxygen...
Peripheral neurotoxicity is one of the most distressing side effects oxaliplatin therapy for cancer. Indeed, patients that received experience acute and/or chronic severe sensory peripheral neuropathy. However, despite similar co-morbidities, cancer stage, demographics and treatment schedule, develop oxaliplatin-induced with remarkably different severity. This suggests individual genetic variability, which might be used to glean mechanistic insights into neurotoxicity. We characterized...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Summary High plasma levels of nicotinamide phosphoribosyltransferase ( NAMPT ), traditionally considered an intracellular enzyme with a key role in NAD synthesis, have been reported several oncological, inflammatory and metabolic diseases. We now show that e can be actively released by melanoma cells vitro. analysed the mechanisms its release, we found both classical non‐classical pathway involvement. cells, our hands, has paracrine autocrine effects: it activates MAPK , AKT NF ‐ κ B...
Abstract Background Alzheimer's disease ( AD ) is a neurodegenerative disorder featured by deposition of beta‐amyloid (Aβ) plaques in the hippocampus and associated cortices progressive cognitive decline. Tropisetron, selective 5‐ HT 3 receptor antagonist, conventionally used to counteract chemotherapy‐induced emesis. Recent investigations describe antiphlogistic properties for tropisetron. It has been shown that tropisetron protects against rat embolic stroke. We investigated protective...