A5024445685- Pharmaceutical Economics and Policy
- Health Systems, Economic Evaluations, Quality of Life
- Alzheimer's disease research and treatments
- Biosimilars and Bioanalytical Methods
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Pharmaceutical studies and practices
- Workaholism, burnout, and well-being
- Garlic and Onion Studies
- Journalism and Media Studies
- Liver Diseases and Immunity
- Mast cells and histamine
- Pediatric Hepatobiliary Diseases and Treatments
- Advertising and Communication Studies
- Adenosine and Purinergic Signaling
- Liver Disease Diagnosis and Treatment
- Trace Elements in Health
- melanin and skin pigmentation
- Calcium signaling and nucleotide metabolism
- Ion Channels and Receptors
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2013-2015
The amyloid hypothesis of Alzheimer's disease (AD) suggests that soluble β (Aβ) is an initiator a cascade events eventually leading to neurodegeneration. Recently, we reported Aβ deranged Ca(2+) homeostasis specifically in hippocampal astrocytes by targeting key elements signaling, such as mGluR5 and IP3 R1. In the present study, dissect signaling which deregulates glial : (i) 100 nM leads increase cytosolic calcium after 4-6 h treatment; (ii) increased 24 (iii) this blocked inhibitors...
Abstract Background Advanced therapy medicinal products (ATMPs) represent an important cornerstone for innovation in healthcare. However, uncertainty on the value, high average cost per patient and their one-shot nature has raised a debate assessment appraisal process pricing reimbursement (P&R) purposes. This led experts providing recommendations this topic. Our primary objective is to investigate ATMPs P&R main five European countries understand if consistent with published expert...
Primary Biliary Cholangitis, previously known as Cirrhosis, is a rare disease, which mainly affects women in their fifth to seventh decades of life. It chronic autoimmune disease characterized by progressive damage interlobular bile ducts leading ductopenia, cholestasis and acids retention. Even if the usually presents long asymptomatic phase slow progression, many patients it may progress faster toward cirrhosis its complications. The 10year mortality greater than diseases such human...
Objectives: To describe the length of time taken by Italian Medicines Agency (AIFA) to formulate pricing and reimbursement decisions for drugs approved via centralized procedures evaluate possible differences between categories (innovative drugs, oncological rare disease products negotiated with Managed Entry Agreements and/or managed registry). Methods: Monthly meeting reports Technical Scientific Committee (CTS) Price Reimbursement (CPR) as well European Official Journals were scrutinized...
Objective. To compare the time-to-reimbursement of last two committees Italian Medicines Agency (AIFA), respectively appointed in 2015 and 2018.
 Methods. The analysis was run through a specific internal database created by MA-Provider. populated with information regarding European (EMA) approved new drugs, including each step Price Reimbursement (P&R) process reported monthly outcomes Technical Scientific Committee (CTS) (CPR) meetings from September to April 2020.
 Results....
Objectives: To describe the length of time taken by Italian Medicines Agency (AIFA) to formulate pricing and reimbursement decisions for drugs approved via centralized procedures evaluate possible differences between categories (innovative drugs, oncological rare disease products negotiated with Managed Entry Agreements and/or managed registry). Methods: Monthly meeting reports Technical Scientific Committee (CTS) Price Reimbursement (CPR) as well European Official Journals were scrutinized...