A5026776294- Cancer Treatment and Pharmacology
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Colorectal Cancer Treatments and Studies
- Multiple Myeloma Research and Treatments
- Plant-based Medicinal Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nerve injury and regeneration
- Pain Management and Opioid Use
- Pediatric Pain Management Techniques
- Anesthesia and Pain Management
- Pharmacogenetics and Drug Metabolism
- Pain Management and Placebo Effect
- Cancer survivorship and care
- Nutrition and Health in Aging
- Neuroscience and Neuropharmacology Research
- Cancer-related cognitive impairment studies
- Chemotherapy-related skin toxicity
- Botulinum Toxin and Related Neurological Disorders
- Spinal Cord Injury Research
- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Signaling Pathways in Disease
- Frailty in Older Adults
- Health, Environment, Cognitive Aging
University of Maryland, Baltimore
2015-2024
Maryland Department of Health
2023
Geriatric Research Education and Clinical Center
2023
National Institutes of Health
2018-2022
University of Delaware
2018-2022
National Institute of Nursing Research
2006-2022
University of Connecticut
2019
Virginia Commonwealth University
2019
University of Florida
2019
University of Baltimore
2007-2017
Background: A major clinical issue affecting 10-40% of cancer patients treated with oxaliplatin is severe peripheral neuropathy symptoms including cold sensitivity and neuropathic pain. Rat models have been used to describe the pathological features oxaliplatin-induced neuropathy; however, they are inadequate for parallel studies oxaliplatin's antineoplastic activity neurotoxicity because most developed in mice. Thus, we characterized effects chronic, bi-weekly administration BALB/c We first...
Bortezomib is the first proteasome inhibitor with significant antineoplastic activity for treatment of relapsed/refractory multiple myeloma as well other hematological and solid neoplasms. Peripheral neurological complications manifesting paresthesias, burning sensations, dysesthesias, numbness, sensory loss, reduced proprioception vibratory sensitivity are among major limiting side effects associated bortezomib therapy. Although bortezomib-induced painful peripheral neuropathy clinically...
Following spinal cord injury (SCI), astrocytes demonstrate long-lasting reactive changes, which are associated with the persistence of neuropathic pain and motor dysfunction. We previously demonstrated that upregulation trkB.T1, a truncated isoform brain-derived neurotrophic factor receptor (BDNF), contributes to gliosis after SCI, but little is known about effects trkB.T1 on function astrocytes. As sole trkB receptors expressed astrocytes, we examined trkB.T1-driven in vitro vivo ....
BackgroundPrecision health considers individual lifestyle, genetics, behaviors, and environment context facilitates interventions aimed at helping individuals achieve well-being optimal health.PurposeTo present the Nursing Science Precision Health (NSPH) Model describe integration of precision concepts within domains symptom self-management science as reflected in National Institute Research P30 Centers Excellence P20 Exploratory Centers.MethodsCenter members developed NSPH manuscript based...
Chronic pain after spinal cord injury (SCI) may present as hyperalgesia, allodynia, and/or spontaneous and is often resistant to conventional medications. Identifying more effective interventions manage SCI requires improved understanding of the pathophysiological mechanisms involved. Cell cycle activation (CCA) has been implicated a key event following SCI. We have shown that early central or systemic administration cell inhibitor reduces CCA, prevents glial changes, limits SCI-induced...
Peripheral neurotoxicity is one of the most distressing side effects oxaliplatin therapy for cancer. Indeed, patients that received experience acute and/or chronic severe sensory peripheral neuropathy. However, despite similar co-morbidities, cancer stage, demographics and treatment schedule, develop oxaliplatin-induced with remarkably different severity. This suggests individual genetic variability, which might be used to glean mechanistic insights into neurotoxicity. We characterized...
Abstract Purpose: Discovery of SNPs that predict a patient's risk docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives this analysis were discover associated with mechanistically validate these associations in preclinical models drug-induced neuropathy. Experimental Design: A genome-wide association study was conducted metastatic castrate-resistant prostate cancer patients treated docetaxel, prednisone...
The mechanisms underlying the transition from acute to chronic pain remain unclear. Here, we sought characterize transcriptome associated with low back as well of pain. For analysis, compared whole blood of: (a) patients at onset who no longer had within 6 weeks after (acute) developed months (chronic T5); and, (b) T1) healthy pain-free (normal) controls. majority differentially expressed genes were protein coding. We illustrate a unique characterized by significant enrichment for known...
This study evaluated the contributions of psychological status and cardiovascular responsiveness to racial/ethnic differences in experimental pain sensitivity. The baseline measures 3,159 healthy individuals—non-Hispanic white (NHW): 1,637, African-American (AA): 1,012, Asian: 299, Hispanic: 211—from OPPERA prospective cohort were used. Cardiovascular included structural equation modeling based mediation analyses. Pain catastrophizing was a significant mediator for associations between...
There is no agreement on the gold standard for detection and grading of chemotherapy-induced peripheral neurotoxicity (CIPN) in clinical trials. The objective to perform an observational prospective study assess compare patient-based physician-based methods CIPN.Consecutive patients, aged 18 years or older, candidates neurotoxic chemotherapy, were enrolled United States, European Union, Australia. A trained investigator performed scales (Total Neuropathy Score-clinical [TNSc], used calculate...
Chemotherapy-induced peripheral neuropathy (CIPN) lacks standardized clinical measurement. The objective of the current secondary analysis was to examine data from CIPN Outcomes Standardization (CI-PeriNomS) study for associations between examinations and neurophysiological abnormalities. Logistic regression estimated strength vibration, pin, monofilament with lower limb sensory motor amplitudes. Examinations were classified as normal (0), moderately abnormal (1), or severely (2). Among 218...
Neurotrophin-dependent activation of the tyrosine kinase receptor trkB.FL modulates neuromuscular synapse maintenance and function; however, it is unclear what role alternative splice variant, truncated trkB (trkB.T1), may have in peripheral axis. We examined this question trkB.T1 null mice demonstrate that vivo performance nerve-evoked muscle tension are significantly increased. In vitro assays indicated gain-in-function trkB.T1(-/-) animals resulted specifically from an increased...
Background Animal models in pain research have suggested that inclusion of both evoked and nonevoked behavioral measures is needed to better reflect the human experience. Individuals with chronic are known experience spontaneous pain, addition after exposure an external stimulus. Recently, dynamic weight bearing (DWB) apparatus was developed assess for hyperalgesia by capturing surface distribution paws mice acute inflammation. Objectives The aim this study evaluate DWB test as a measure...
Abstract Purpose Biomarkers as common data elements (CDEs) are important for the characterization of biobehavioral symptoms given that once a biologic moderator or mediator is identified, biologically based strategies can be investigated treatment efforts. Just symptom inventory reflects experience, biomarker an indicator symptom, though not per se. The purposes this position paper to (a) identify “minimum set” biomarkers consideration CDEs in and self‐management science, specifically...
Abstract Nucleoside reverse transcriptase inhibitors (NRTIs) are key components of HIV/AIDS treatment to reduce viral load. However, these drugs can induce chronic neuropathic pain, leading increased morbidity in HIV patients. This study examines the role brain‐derived neurotrophic factor (BDNF) spinal dorsal horn (SDH) development mechanical allodynia male C57BL/6J mice treated with NRTI stavudine (d4T). After d4T administration, developed neuronal activity and BDNF expression SDH hind paw...
Brain-Derived Neurotrophic Factor (BDNF) is a central nervous system modulator of nociception. In animal models chronic pain, BDNF exerts its effects on nociceptive processing by binding to the full-length receptor tropomyosin-related kinase B (trkB.FL) and transducing intracellular signaling produce nocifensive behaviors. addition trkB.FL, trkB locus also produces widely-expressed alternatively-spliced truncated isoform, trkB.T1. TrkB.T1 binds with high affinity; however unique 11 amino...
Excitement grows for the advancement of science to improve human health outcomes in emerging precision era. For nurse scientists and nursing science, opportunities this era can be realized through careful attention philosophical theoretical underpinnings "precision science," as well application rigorous processes necessary support development more accurate diagnostics targeted treatments. Currently, there are multiple innovative initiatives that important with specific overlaps aims...