A5016703797- Cancer Treatment and Pharmacology
- Cancer survivorship and care
- Chemotherapy-related skin toxicity
- Colorectal Cancer Treatments and Studies
- Childhood Cancer Survivors' Quality of Life
- Pain Mechanisms and Treatments
- Multiple Myeloma Research and Treatments
- Palliative Care and End-of-Life Issues
- Silymarin and Mushroom Poisoning
- Bacterial Identification and Susceptibility Testing
- Neutropenia and Cancer Infections
- Management of metastatic bone disease
- Fungal Biology and Applications
- Patient-Provider Communication in Healthcare
- Musculoskeletal pain and rehabilitation
- Family Support in Illness
- Pain Management and Opioid Use
- Nutrition and Health in Aging
- Ion Channels and Receptors
- Endometrial and Cervical Cancer Treatments
- Spine and Intervertebral Disc Pathology
- Complementary and Alternative Medicine Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sleep and related disorders
- Polysaccharides and Plant Cell Walls
Beatson West of Scotland Cancer Centre
2015-2023
Gartnavel General Hospital
2016-2023
Western General Hospital
2007-2020
University of Edinburgh
2010-2015
Edinburgh Cancer Research
2007-2014
Southern General Hospital
2013
National Health Service
2008
University of Oxford
2008
Japan External Trade Organization
1989
Purpose Cancer is associated with an increased risk of suicide and attempted suicide. However, we do not know how many cancer patients have thoughts that they would be better off dead or hurting themselves. This study aimed to determine the prevalence such in outpatients which are most likely them. Patients Methods A survey consecutive who attended outpatient clinics a regional center Edinburgh, United Kingdom. completed Patient Health Questionnaire-9 (PHQ-9), included Item 9 asks if had...
To: (1) estimate the prevalence of clinically significant emotional distress in patients attending a cancer outpatient department and (2) determine associations between demographic clinical variables, we conducted survey outpatients selected clinics regional centre Edinburgh, UK. Patients completed Hospital Anxiety Depression Scale (HADS) on touch-screen computers scores were linked to variables hospital database. Nearly one quarter 674 out 3071 (22%; 95% confidence interval (CI) 20-23%) met...
Effective treatment of neuropathic pain without unacceptable side effects is challenging. Cancer sufferers increasingly live with long-term treatment-related pain, resulting from chemotherapy-induced peripheral neuropathy (CIPN) or surgical scars. This proof-of-concept study aimed to determine whether preclinical evidence for TRPM8 ion channels in sensory neurons as a novel analgesic target could be translated clinical benefit patients using the activator menthol. Patients problematic...
Clinicopathological features and outcome of women with endometrioid serous ovarian adenocarcinoma were compared.Between 1984 2004, baseline follow-up data prospectively recorded on 1545 patients cancer. Of these, 270 had pure tumors; 659 the ovary. Response to platinum-based chemotherapy (PBC) overall survival, stage-for-stage median progression-free survival (PFS), cause-specific compared. Independent predictors examined by using multivariate analyses.Median age diagnosis for tumors was...
Abstract Background Although it is increasingly recognized that cancer patients often have sleep problems, we lack data on their prevalence and associations in representative clinical populations. We aimed to determine (i) the of problems amongst outpatients a centre (ii) association with medical variables, emotional distress pain. Methods Secondary analysis self‐report 2862 outpatients. Sleep were identified using item from Patient Health Questionnaire‐9: ‘Over last two weeks, how you been...
Chemotherapy-induced peripheral neuropathy (CIPN) lacks standardized clinical measurement. The objective of the current secondary analysis was to examine data from CIPN Outcomes Standardization (CI-PeriNomS) study for associations between examinations and neurophysiological abnormalities. Logistic regression estimated strength vibration, pin, monofilament with lower limb sensory motor amplitudes. Examinations were classified as normal (0), moderately abnormal (1), or severely (2). Among 218...
<h3>Introduction</h3> People living with and beyond cancer are vulnerable to a number of physical, functional psychological issues. Undertaking holistic needs assessment (HNA) is one way support structured discussion patients’ within clinical consultation. However, there little evidence on how HNA impacts the dynamics This study aims establish (1) affects type conversation that goes during consultation (2) these putative changes impact shared decision-making self-efficacy. <h3>Methods...
<h2>Abstract</h2><h3>Objectives</h3> To determine whether early switch to oral antibiotic treatment in adults with neutropenic sepsis at low risk of complications, is non-inferior switching later. <h3>Methods</h3> This non-inferiority, parallel group, randomized, open-label clinical trial enrolled UK hospitalized sepsis. Participants were randomly assigned either ciprofloxacin plus co-amoxiclav within 12-24 hours or continue intravenous for least 48 hours. The primary outcome was a composite...
Neutropenic sepsis is a common complication of systemic anticancer treatment. There variation in practice timing switch to oral antibiotics after commencement empirical intravenous antibiotic therapy.
9129 Background: CIPN is a common dose-limiting toxicity. Mostly symptoms resolve several months post-treatment, but significant proportion of patients are left with long-term pain and disability which difficult to treat. The available systemic agents have limited efficacy, cause side effects take weeks/months work. Based on preclinical work showing marked analgesic topical transient receptor potential melastatin (TRPM8) activators in neuropathic (Proudfoot, Curr Biol 2006;16;1591-1605) we...
The authors wish to bring the readers' attention following error in aforementioned paper. Dr Leanne Fleming was inadvertently omitted from authorship. Contact details: Sackler Institute of Psychobiological Research Southern General Hospital, Glasgow G51 4TF Scotland, UK