A5026175248- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Pharmacogenetics and Drug Metabolism
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Plant-based Medicinal Research
- Multiple Myeloma Research and Treatments
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Drug-Induced Ocular Toxicity
- 3D Printing in Biomedical Research
- Lung Cancer Treatments and Mutations
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Phytochemistry and Bioactive Compounds
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
University of Hawaii Cancer Center
2020-2024
University of Maryland, Baltimore
2016-2024
University of Hawaiʻi at Mānoa
2020-2024
University of Hawaii System
2020-2024
Cancer Center of Hawaii
2020-2023
National Institute of Nursing Research
2018
National Institutes of Health
2018
Abstract Purpose: Discovery of SNPs that predict a patient's risk docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives this analysis were discover associated with mechanistically validate these associations in preclinical models drug-induced neuropathy. Experimental Design: A genome-wide association study was conducted metastatic castrate-resistant prostate cancer patients treated docetaxel, prednisone...
The mechanisms underlying the transition from acute to chronic pain remain unclear. Here, we sought characterize transcriptome associated with low back as well of pain. For analysis, compared whole blood of: (a) patients at onset who no longer had within 6 weeks after (acute) developed months (chronic T5); and, (b) T1) healthy pain-free (normal) controls. majority differentially expressed genes were protein coding. We illustrate a unique characterized by significant enrichment for known...
Preeclampsia is a pregnancy-specific syndrome characterized by hypertension and proteinuria after 20 weeks of gestation. However, it not well understood what lipids are involved in the development this condition, even less known how these mediate its formation. To reveal relationship between preeclampsia, we conducted lipidomic profiling maternal sera 44 severe preeclamptic healthy pregnant women from multi-ethnic cohort Hawaii. Correlation network analysis showed that oxidized phospholipids...
Background Multiple cell signaling pathways are implicated in the development, progression, and persistence of cisplatin-induced peripheral neuropathy. Although advances have been made terms understanding specific neurotoxic mechanisms, there few predictive factors identified that can help inform clinician approach to symptom prevention or management. Objective We investigate differential sensitivity neuropathy examine contribution dorsal root ganglion (DRG) transcriptional profiles across...
Variations in telomere length (TL) have been associated with aging, stress, and many diseases. Placenta TL is an essential molecular component influencing the outcome of birth. Previous investigations into relationship between placenta preeclampsia (PE) produced conflicting findings. We conducted a retrospective case-control analysis this study to address disparity. used samples from 224 births received Hawaii Biorepository (HiBR) 2006 2013, comprising 129 healthy full-term controls 95...
Epigenome-wide DNA methylation analysis (EWAS) is an important approach to identify biomarkers for early disease detection and prognosis prediction, yet its results could be confounded by other factors such as cell-type heterogeneity patient characteristics. In this study, we address the importance of confounding adjustment examining patterns in cord blood exposed severe preeclampsia (PE), a prevalent potentially fatal pregnancy complication. Without adjustment, misleading global...
Abstract The objective of this study was to discover clinical and pharmacogenetic factors associated with bevacizumab-related gastrointestinal hemorrhage in Cancer Leukemia Group B (Alliance) 90401. Patients metastatic castration-resistant prostate cancer received docetaxel prednisone ± bevacizumab. were genotyped using Illumina HumanHap610-Quad assessed cause-specific risk for association between single nucleotide polymorphisms (SNPs) hemorrhage. In 1008 patients, grade 2 or higher occurred...
Abstract Background Maternal obesity is a health concern that may predispose newborns to high risk of medical problems later in life. To understand the transgenerational effect maternal obesity, we conducted multi-omics study, using DNA methylation and gene expression CD34+/CD38-/Lin-umbilical cord blood hematopoietic stem cells (uHSCs) metabolomics blood, all from multi-ethnic cohort (n=72) Kapiolani Medical Center for Women Children Honolulu, Hawaii (collected between 2016 2018). Results...
ABSTRACT Preeclampsia is a pregnancy specific syndrome characterized by hypertension and proteinuria after 20 weeks of gestation. To reveal the relationship between lipids preeclampsia, we conduct lipidomic profiling maternal serums 44 severe preeclamptic healthy pregnancies from multi-ethnic cohort in Hawaii. Correlation network analysis shows that oxidized phospholipids (OxPLs) have increased inter-correlations connections while other lipids, including triacylglycerols (TAGs), reduced...
Abstract Background: Treatment-related GI HEM is a major health concern with few known predictive risk factors. The objective of this analysis was to discover clinical and genetic factors that modulate in large randomized phase III study. Methods: Chemotherapy-naïve mCRPC pts were 1:1 receive docetaxel prednisone ± BEV once every 21 days for up two years (N = 1008). Cause-specific time-to-event using Cox regression model used investigate the association between grade 2+ (designated as at...
<p>Sensitivity to mechanical stimuli with Von Frey filaments for C57BL/6J mice and litter-mates heterozygous VAC14 prior docetaxel treatment. The figure displays the estimate of proportion without a hind-paw withdrawal response stimulation by each fiber weight, e.g., no respond fibers {less than or equal to}0.2 g all fibers{greater to}1.4 g. (hatched line) are more likely wild-type (solid respond, meaning they sensitive nociceptive (p=0.0012). Gray lines denote 95% confidence...
<p>Peripheral neuronal cells (Peri.4U) treated with docetaxel were found to have a significant decrease in sensitivity for A) mean process lengths but not B) outgrowth intensity or C) relative straightness as measured after 24 hours post-drug treatment. For paclitaxel treatment at the same time point, also significantly decreased D) length and E) F) straightness. Neurite parameters MetaXPress® software averaged from 3 independent experiments. Error bars represent standard error of...
<p>CONSORT diagram illustrating patient flow from enrollment on parent study to population included in pharmacogenetic discovery analysis and quality control filtering of SNPs the Illumina HumanHap610-Quad into analysis.</p>
<div>Abstract<p><b>Purpose:</b> Discovery of SNPs that predict a patient's risk docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives this analysis were discover associated with mechanistically validate these associations in preclinical models drug-induced neuropathy.</p><p><b>Experimental Design:</b> A genome-wide association study was conducted metastatic...
<div>Abstract<p><b>Purpose:</b> Discovery of SNPs that predict a patient's risk docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives this analysis were discover associated with mechanistically validate these associations in preclinical models drug-induced neuropathy.</p><p><b>Experimental Design:</b> A genome-wide association study was conducted metastatic...
<p>Sensitivity to mechanical stimuli with Von Frey filaments for C57BL/6J mice and litter-mates heterozygous VAC14 prior docetaxel treatment. The figure displays the estimate of proportion without a hind-paw withdrawal response stimulation by each fiber weight, e.g., no respond fibers {less than or equal to}0.2 g all fibers{greater to}1.4 g. (hatched line) are more likely wild-type (solid respond, meaning they sensitive nociceptive (p=0.0012). Gray lines denote 95% confidence...
<p>Peripheral neuronal cells (Peri.4U) treated with docetaxel were found to have a significant decrease in sensitivity for A) mean process lengths but not B) outgrowth intensity or C) relative straightness as measured after 24 hours post-drug treatment. For paclitaxel treatment at the same time point, also significantly decreased D) length and E) F) straightness. Neurite parameters MetaXPress® software averaged from 3 independent experiments. Error bars represent standard error of...
<p>CONSORT diagram illustrating patient flow from enrollment on parent study to population included in pharmacogenetic discovery analysis and quality control filtering of SNPs the Illumina HumanHap610-Quad into analysis.</p>