A5050159421- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Pharmacogenetics and Drug Metabolism
- Plant-based Medicinal Research
- Pain Mechanisms and Treatments
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Innovative Microfluidic and Catalytic Techniques Innovation
- Peripheral Neuropathies and Disorders
- Drug-Induced Ocular Toxicity
- 3D Printing in Biomedical Research
- Nerve injury and regeneration
- HIV Research and Treatment
- Genetics and Neurodevelopmental Disorders
- Acupuncture Treatment Research Studies
- Health Sciences Research and Education
- Simulation-Based Education in Healthcare
- Pharmacological Effects and Toxicity Studies
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- Botulinum Toxin and Related Neurological Disorders
- Interprofessional Education and Collaboration
University of Maryland, Baltimore
2007-2018
National Institute of Nursing Research
2018
National Institutes of Health
2018
University of Maryland, College Park
2009
University of Baltimore
2007
Abstract Purpose: Discovery of SNPs that predict a patient's risk docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives this analysis were discover associated with mechanistically validate these associations in preclinical models drug-induced neuropathy. Experimental Design: A genome-wide association study was conducted metastatic castrate-resistant prostate cancer patients treated docetaxel, prednisone...
Abstract Nucleoside reverse transcriptase inhibitors (NRTIs) are key components of HIV/AIDS treatment to reduce viral load. However, these drugs can induce chronic neuropathic pain, leading increased morbidity in HIV patients. This study examines the role brain‐derived neurotrophic factor (BDNF) spinal dorsal horn (SDH) development mechanical allodynia male C57BL/6J mice treated with NRTI stavudine (d4T). After d4T administration, developed neuronal activity and BDNF expression SDH hind paw...
Painful peripheral neuropathy is a debilitating complication of the treatment HIV with nucleoside reverse transcriptase inhibitors (NRTIs). Patients are living longer these drugs; however many develop excruciating, unremitting, and often treatment-limiting that resistant to conventional pain management therapies. Improving patient comfort quality life paramount depends on clearer understanding this devastating side effect. The mechanisms underlying development NRTI-induced neuropathy,...
Background Multiple cell signaling pathways are implicated in the development, progression, and persistence of cisplatin-induced peripheral neuropathy. Although advances have been made terms understanding specific neurotoxic mechanisms, there few predictive factors identified that can help inform clinician approach to symptom prevention or management. Objective We investigate differential sensitivity neuropathy examine contribution dorsal root ganglion (DRG) transcriptional profiles across...
<p>Sensitivity to mechanical stimuli with Von Frey filaments for C57BL/6J mice and litter-mates heterozygous VAC14 prior docetaxel treatment. The figure displays the estimate of proportion without a hind-paw withdrawal response stimulation by each fiber weight, e.g., no respond fibers {less than or equal to}0.2 g all fibers{greater to}1.4 g. (hatched line) are more likely wild-type (solid respond, meaning they sensitive nociceptive (p=0.0012). Gray lines denote 95% confidence...
<p>Peripheral neuronal cells (Peri.4U) treated with docetaxel were found to have a significant decrease in sensitivity for A) mean process lengths but not B) outgrowth intensity or C) relative straightness as measured after 24 hours post-drug treatment. For paclitaxel treatment at the same time point, also significantly decreased D) length and E) F) straightness. Neurite parameters MetaXPress® software averaged from 3 independent experiments. Error bars represent standard error of...
<p>CONSORT diagram illustrating patient flow from enrollment on parent study to population included in pharmacogenetic discovery analysis and quality control filtering of SNPs the Illumina HumanHap610-Quad into analysis.</p>
<div>Abstract<p><b>Purpose:</b> Discovery of SNPs that predict a patient's risk docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives this analysis were discover associated with mechanistically validate these associations in preclinical models drug-induced neuropathy.</p><p><b>Experimental Design:</b> A genome-wide association study was conducted metastatic...
<div>Abstract<p><b>Purpose:</b> Discovery of SNPs that predict a patient's risk docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives this analysis were discover associated with mechanistically validate these associations in preclinical models drug-induced neuropathy.</p><p><b>Experimental Design:</b> A genome-wide association study was conducted metastatic...
<p>Sensitivity to mechanical stimuli with Von Frey filaments for C57BL/6J mice and litter-mates heterozygous VAC14 prior docetaxel treatment. The figure displays the estimate of proportion without a hind-paw withdrawal response stimulation by each fiber weight, e.g., no respond fibers {less than or equal to}0.2 g all fibers{greater to}1.4 g. (hatched line) are more likely wild-type (solid respond, meaning they sensitive nociceptive (p=0.0012). Gray lines denote 95% confidence...
<p>Peripheral neuronal cells (Peri.4U) treated with docetaxel were found to have a significant decrease in sensitivity for A) mean process lengths but not B) outgrowth intensity or C) relative straightness as measured after 24 hours post-drug treatment. For paclitaxel treatment at the same time point, also significantly decreased D) length and E) F) straightness. Neurite parameters MetaXPress® software averaged from 3 independent experiments. Error bars represent standard error of...
<p>CONSORT diagram illustrating patient flow from enrollment on parent study to population included in pharmacogenetic discovery analysis and quality control filtering of SNPs the Illumina HumanHap610-Quad into analysis.</p>