A5027737387- MicroRNA in disease regulation
- Pain Mechanisms and Treatments
- Circular RNAs in diseases
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Spinal Cord Injury Research
Following spinal cord injury (SCI), astrocytes demonstrate long-lasting reactive changes, which are associated with the persistence of neuropathic pain and motor dysfunction. We previously demonstrated that upregulation trkB.T1, a truncated isoform brain-derived neurotrophic factor receptor (BDNF), contributes to gliosis after SCI, but little is known about effects trkB.T1 on function astrocytes. As sole trkB receptors expressed astrocytes, we examined trkB.T1-driven in vitro vivo ....
Spinal cord injury (SCI) causes neuronal cell death and vascular damage, which contribute to neurological dysfunction. Given that many biochemical changes such secondary injury, treatment approaches have increasingly focused on combined therapies or use of multi-functional drugs. MicroRNAs (miRs) are small (20-23 nucleotide), non-protein-coding RNAs can negatively regulate target gene expression at the post-transcriptional level. As individual miRs potentially modulate multiple relevant...