A5017354943- Pulmonary Hypertension Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Cardiovascular Issues in Pregnancy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Disease and Transplantation
- Vascular Anomalies and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ultrasound in Clinical Applications
- Heart Failure Treatment and Management
- Congenital Heart Disease Studies
- Atrial Fibrillation Management and Outcomes
- Systemic Sclerosis and Related Diseases
- Tracheal and airway disorders
- Acute Myocardial Infarction Research
- Organ Transplantation Techniques and Outcomes
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Advanced MRI Techniques and Applications
- Hemodynamic Monitoring and Therapy
- Asthma and respiratory diseases
- Central Venous Catheters and Hemodialysis
- Atomic and Subatomic Physics Research
- Renal Transplantation Outcomes and Treatments
University of Pennsylvania
2015-2024
Penn Presbyterian Medical Center
2009-2024
Pulmonary and Allergy Associates
2011-2024
University of Pittsburgh Medical Center
2019
California University of Pennsylvania
2018
Anna Needs Neuroblastoma Answers
2018
Cleveland Clinic Florida
2016
Cardiovascular Institute of the South
2012-2014
Brown University
2014
Penn Center for AIDS Research
2014
Pulmonary embolism is a potentially fatal disorder. Information about the outcome of clinically recognized pulmonary sparse, particularly given that new treatments for more seriously ill patients are now available.We prospectively followed 399 with diagnosed by lung scanning and angiography, who were enrolled in multicenter diagnostic trial. We reviewed all hospitalizations, investigations embolism, deaths among within one year diagnosis.Of patients, 375 (94 percent) received treatment...
Pulmonary embolism (PE) is a life-threatening condition and leading cause of morbidity mortality. There have been many advances in the field PE last few years, requiring careful assessment their impact on patient care. However, variations recommendations by different clinical guidelines, as well lack robust trials, make decisions challenging. The Embolism Response Team Consortium an international association created to advance diagnosis, treatment, outcomes patients with PE. In this...
Study objectives To determine the incidence of primary graft failure (PGF) following lung transplantation, assess possible risk factors, and characterize its effect on outcomes. Methods Retrospective review 100 consecutive patients undergoing transplantation at University Pennsylvania Medical Center. Fifteen meeting diagnostic criteria for PGF (PGF+ group) were compared with 85 without this complication (PGF– group). Results The was 15%. There no significant difference in age, sex,...
To determine correlates of survival in primary pulmonary hypertension, we compared 41 echocardiography-Doppler and nine catheterization parameters with outcome 26 patients. Mean follow-up was 19.7 months survivors; mean 4.8 16 nonsurvivors. Cox life-table univariate analysis correlated two echocardiographic, three Doppler, variables poor (p less than or equal to 0.05), chi 2 ensured the best critical values: severity pericardial effusion, heart rate more 87 beats/min, pulmonic flow...
The use of pharmacologic agents in the treatment pulmonary hypertension has not proved to be uniformly successful or predictable. One possible reason for vagaries response is that vascular lesions are consistent. We examined relation between structure resistance vessels unexplained (primary) and vasodilators. Our study involved 19 patients with clinically (mean pressure, 59 +/- 14 mm Hg). After characterizing them performing control hemodynamic measurements, we determined acute effects a...
Systolic deceleration or "notching" of the right ventricular outflow tract Doppler flow velocity envelope (FVE(RVOT)) relates to pathologic wave reflection in setting elevated pulmonary artery impedance.We investigated whether simple visual assessment FVE(RVOT) morphology aids hemodynamic differentiation and detection vascular disease among a referral hypertension (PH) cohort.We reviewed hemodynamics, echocardiography, clinical data for 88 patients referred PH 32 subjects with systolic heart...
Recent reports have suggested a possible association between HIV-1 infection and primary pulmonary hypertension (PPH), but most of the patients described to date either had acquired immunodeficiency syndrome (AIDS) with concurrent lung infections or administered Factor VIII intravenously for hemophilia. We report three human virus type 1 (HIV-1)-positive homosexual white males clinical hemodynamic diagnoses PPH. None any opportunistic other pathology, nor were they hemophiliacs. They no...
Abstract Background Improved outcomes with expanding treatment options for patients pulmonary arterial hypertension present the opportunity to consider additional end-points in approaching therapy, including factors that influence health-related quality of life. However, comparatively little is known about life and its determinants hypertension. Methods Health-related was evaluated a cross sectional study 155 outpatients using generic respiratory-disease specific measurement tools. Most had...
Pulmonary arterial hypertension (PAH) is a progressive disease that causes exercise limitation, heart failure, and death. We aimed to determine the safety efficacy of aspirin simvastatin in PAH.We performed randomized, double-blind, placebo-controlled 2×2 factorial clinical trial patients with PAH receiving background therapy at 4 centers. A total 92 were be randomized 81 mg or matching placebo 40 placebo. The primary outcome was 6-minute walk distance 6 months. Sixty-five subjects had been...
Rationale: Recent studies have focused on the role of female sex and estradiol (E2) in pulmonary arterial hypertension (PAH), but it is not known whether hormones are risk factors for PAH men.Objectives: We performed a case-control study to determine hormone levels (E2, dehydroepiandrosterone-sulfate [DHEA-S], testosterone) associated with men.Methods: Plasma men idiopathic, heritable, or connective tissue disease–associated were compared those from age- body mass index–matched without...
Rationale: The aromatase inhibitor anastrozole blocks the conversion of androgens to estrogen and blunts pulmonary hypertension in animals, but its efficacy treating patients with arterial (PAH) is unknown.Objectives: We aimed determine safety PAH.Methods: performed a randomized, double-blind, placebo-controlled trial PAH who received background therapy at two centers.Measurements Main Results: A total 18 were randomized 1 mg or matching placebo 2:1 ratio. co–primary outcomes percent change...
It is not known whether patients with pulmonary arterial hypertension associated portal (portopulmonary (PPHTN) have different disease characteristics from those of other forms hypertension. We performed a retrospective cohort study PPHTN and that was idiopathic, familial, or anorexigen use (IPAH) to determine hemodynamics survival were between these groups. included consecutive who underwent initial artery catheterization vasodilator testing at our center January 1997 May 2001 followed...
High oestradiol (E2) and low dehydroepiandrosterone-sulfate (DHEA-S) levels are risk factors for pulmonary arterial hypertension (PAH) in men, but whether sex hormones related to PAH women is unknown. Post-menopausal aged ≥55 years with were matched by age body mass index without cardiovascular disease. Plasma hormone measured immunoassay. Lower of DHEA-S (p<0.001) higher E2 (p=0.02) associated PAH. In cases (n=112), lower worse haemodynamics (all p<0.01) more right ventricular...
This study compares the benefits of aspirin and warfarin prophylactic agents for patients with thromboembolic disease after total joint arthroplasty. It is a prospective randomized 388 having hip or knee surgery. All consecutive surgery were entered into this evaluated preoperative postoperative ventilation perfusion scans venogram. The treatment groups compared by size location venographically revealed clots changes in scans. results showed that there was no difference deep venous...