A5100680619- Systemic Lupus Erythematosus Research
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Inflammatory Myopathies and Dermatomyositis
- Sepsis Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Transplantation: Methods and Outcomes
- Autoimmune Bullous Skin Diseases
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Disorders and Syndromes
- Congenital Diaphragmatic Hernia Studies
- Hip and Femur Fractures
- Psoriasis: Treatment and Pathogenesis
- Organ Transplantation Techniques and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetic Mapping and Diversity in Plants and Animals
- Cardiac, Anesthesia and Surgical Outcomes
- Gene expression and cancer classification
- Renal Transplantation Outcomes and Treatments
- Systemic Sclerosis and Related Diseases
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- MicroRNA in disease regulation
University of Pennsylvania
2016-2025
University of Science and Technology Beijing
2022-2025
California University of Pennsylvania
2019-2025
Jilin University
2025
First Affiliated Hospital of Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2025
Beijing Children’s Hospital
2025
Capital Medical University
2025
Northwestern University
2025
Journal Article Variable selection in regression with compositional covariates Get access Wei Lin, Lin Department of Biostatistics and Epidemiology, Perelman School Medicine, University Pennsylvania, Philadelphia, Pennsylvania 19104, U.S.A., weilin1@mail.med.upenn.edupixushi@mail.med.upenn.eduruifeng@mail.med.upenn.eduhongzhe@upenn.edu Search for other works by this author on: Oxford Academic Google Scholar Pixu Shi, Shi Rui Feng, Feng Hongzhe Li Biometrika, Volume 101, Issue 4, December...
The effects of spinal anesthesia as compared with general on the ability to walk in older adults undergoing surgery for hip fracture have not been well studied.
Context: The mechanisms by which testosterone increases hemoglobin and hematocrit are unknown. Objective: aim was to test the hypothesis that testosterone-induced increase in is associated with suppression of iron regulatory peptide hepcidin. Participants: Healthy younger men (ages 19–35 yr; n = 53) older 59–75 56) were studied. Methods: Weekly doses enanthate (25, 50, 125, 300, 600 mg) administered over 20 wk, whereas endogenous suppressed monthly GnRH agonist administration. Blood serum...
<h3>Objective</h3> <i>Helicobacter pylori</i> strains that express the oncoprotein CagA augment risk for gastric cancer. However, precise mechanisms through which <i>cag</i><sup>+</sup> heighten cancer have not been fully delineated and model systems recapitulate niche are critical understanding pathogenesis. Gastroids three-dimensional organ-like structures provide unique opportunities to study host-<i>H. interactions in a preclinical model. We used gastroids inform direct vitro studies...
The incidence of pediatric hospitalizations for community-acquired pneumonia (CAP) has declined after the widespread use heptavalent pneumococcal conjugate vaccine. national outpatient visits CAP, however, is not well established. Although no CAP treatment guidelines are available, current data support narrow-spectrum antibiotics as first-line most patients with CAP.To estimate rates examine time trends in prescribed and determine factors associated broad-spectrum antibiotic prescribing...
Background: Since T cell exclusion contributes to tumor immune evasion and immunotherapy resistance, how improve infiltration into solid tumors becomes an urgent challenge. Methods: We employed deep learning profile the microenvironment (TIME) in triple negative breast cancer (TNBC) samples from TCGA datasets noticed that fibroblast growth factor receptor (FGFR) signaling pathways were enriched immune-excluded phenotype of TNBC. Erdafitinib, a selective FGFR inhibitor, was then used...
Background: The REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture) trial found similar ambulation and survival at 60 days with spinal general anesthesia hip fracture surgery. Trial outcomes evaluating pain, prescription analgesic use, patient satisfaction have not yet been reported. Objective: To compare surgery anesthesia. Design: Preplanned secondary analysis of a pragmatic randomized trial. (ClinicalTrials.gov: NCT02507505) Setting: 46 U.S. Canadian...
Rationale: Inhibition of aromatase with anastrozole reduces pulmonary hypertension in experimental models. Objectives: We aimed to determine whether improved the 6-minute-walk distance (6MWD) at 6 months arterial (PAH). Methods: performed a randomized, double-blind, placebo-controlled phase II clinical trial subjects PAH seven centers. Eighty-four postmenopausal women and men were randomized 1:1 ratio receive 1 mg or placebo by mouth daily, stratified sex using permuted blocks variable...
OBJECTIVES. The goals were to isolate and estimate the genetic susceptibility retinopathy of prematurity. METHODS. A retrospective study (1994–2004) from 3 centers was performed with zygosity data for premature twins who born at a gestational age ≤32 weeks survived beyond postmenstrual 36 weeks. Retinopathy prematurity diagnosed staged by pediatric ophthalmologists each center. Data analyses mixed-effects logistic regression analysis latent variable probit modeling. RESULTS. total 63...
Acute lung injury (ALI) acts as a complex genetic trait, yet its risk factors remain incompletely understood. Large-scale genotyping has not previously been reported for ALI.To identify ALI variants after major trauma using large-scale candidate gene approach.We performed two-stage association study. We derived findings in an African American cohort (n = 222) cardiopulmonary disease-centric 50K single nucleotide polymorphism (SNP) array. Genotype and haplotype distributions were compared...
Abstract Introduction Aromatase inhibitor-associated arthralgia (AIAA) is a common and often debilitating symptom in breast cancer survivors. Since joint symptoms have been related to estrogen deprivation through the menopausal transition, we hypothesized that genetic polymorphisms CYP19A1 , final enzyme synthesis, may be associated with occurrence of AIAA. Methods We performed cross-sectional study postmenopausal women stage 0 III receiving adjuvant aromatase inhibitor (AI) therapy....
Introduction Hip fractures occur 1.6 million times each year worldwide, with substantial associated mortality and losses of independence. At present, anaesthesia care for hip fracture surgery varies widely within between countries, general spinal representing the 2 most common approaches. Limited randomised evidence exists regarding potential short-term or long-term differences in outcomes patients receiving surgery. Methods The REGAIN trial (Regional vs General Anesthesia Promoting...
Plasma interleukin-1 beta may influence sepsis mortality, yet recombinant human receptor antagonist did not reduce mortality in randomized trials. We tested for heterogeneity the treatment effect of by baseline plasma or concentration.Retrospective subgroup analysis controlled trial.Multicenter North American and European clinical trial.Five hundred twenty-nine subjects with hypotension hypoperfusion, representing 59% original trial population.Random assignment placebo × 72 hours.We measured...
Acute Lung Injury (ALI) is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients critical illness. We conducted the first investigation to use genome wide association (GWA) approach identify putative risk variants for ALI. Genome genotyping was performed using Illumina Human Quad 610 BeadChip. two-stage GWA study followed third stage of functional characterization. In discovery phase (Phase 1), we compared 600 European American...
Acute respiratory distress syndrome (ARDS) behaves as a complex genetic trait, yet knowledge of susceptibility factors remains incomplete.
In genetical genomics studies, it is important to jointly analyze gene expression data and genetic variants in exploring their associations with complex traits, where the dimensionality of expressions can both be much larger than sample size. Motivated by such modern applications, we consider problem variable selection estimation high-dimensional sparse instrumental variables models. To overcome difficulty high unknown optimal instruments, propose a two-stage regularization framework for...
Acute respiratory distress syndrome (ARDS) lacks known causal biomarkers. Plasma concentrations of sRAGE (soluble receptor for advanced glycation end products) strongly associate with ARDS risk. However, whether plasma contributes causally to remains unknown.