A5052230290- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intensive Care Unit Cognitive Disorders
- Advanced Glycation End Products research
- SARS-CoV-2 and COVID-19 Research
- Breast Cancer Treatment Studies
- Heart Failure Treatment and Management
- Inflammation biomarkers and pathways
- S100 Proteins and Annexins
- Blood groups and transfusion
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Hemoglobinopathies and Related Disorders
- Climate Change and Health Impacts
- Emergency and Acute Care Studies
- Acute Kidney Injury Research
- Pulmonary Hypertension Research and Treatments
- HER2/EGFR in Cancer Research
University of Pennsylvania
2014-2024
Hospital of the University of Pennsylvania
2016-2024
Pulmonary and Allergy Associates
2015-2024
Center for Translational Molecular Medicine
2024
Translational Therapeutics (United States)
2019-2023
Evanston Hospital
2022
Presbyterian Hospital
2021
Shield Therapeutics (United Kingdom)
2018
Newham University Hospital
2017
Yale University
2012-2013
Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction activation multiple lineages, including T cell activation, oligoclonal plasmablast expansion, Fc trafficking receptor modulation on innate lymphocytes granulocytes, that distinguished cases from...
Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 patients who were hospitalized for COVID-19, hematologic had higher relative to solid cancer. two additional cohorts, flow cytometric serologic analyses demonstrated without similar phenotype during acute whereas impairment B cells severe respiratory syndrome 2 (SARS-CoV-2)-specific antibody responses. Despite impaired...
Rationale: The epidemiology of post–acute care use and hospital readmission after sepsis remains largely unknown.Objectives: To examine the rate to risk factors outcomes for readmissions sepsis.Methods: In an observational cohort study conducted in academic health system (2010–2012), we compared at discharge 3,620 hospitalizations with 108,958 nonsepsis hospitalizations. We used three validated, claims-based approaches identify severe sepsis.Measurements Main Results: Post–acute was more...
Although dozens of studies have associated vancomycin + piperacillin-tazobactam with increased acute kidney injury (AKI) risk, it is unclear whether the association represents true or a pseudotoxicity characterized by isolated effects on creatinine secretion. We tested this hypothesis contrasting changes in concentration after antibiotic initiation cystatin C concentration, biomarker unaffected tubular
Acute respiratory distress syndrome (ARDS) is a common, but under-recognised, critical illness associated with high mortality. An important factor in its under-recognition the variability chest radiograph interpretation for ARDS. We sought to train deep convolutional neural network (CNN) detect ARDS findings on radiographs.CNNs were pretrained 595 506 radiographs from two centres identify common (eg, opacity and effusion), then trained 8072 annotated by multiple physicians using various...
The epidemiology, management, and outcomes of acute respiratory distress syndrome (ARDS) differ between children adults, with lower mortality rates in despite comparable severity hypoxemia. However, the relationship age is unclear.
Expression of cyclins D1 (cD1) and D2 (cD2) in ventricular zone subventricular (SVZ), respectively, suggests that a switch to cD2 could be requisite step the generation cortical intermediate progenitor cells (IPCs). However, direct evidence is lacking. Here, cD1 or was seen colabel subsets Pax6-expressing radial glial (RGCs), whereas only colabeled with Tbr2. Loss IPCs −/− embryonic cortex analysis expression patterns mutant embryos lacking Tbr2 indicate used as progenitors transition from...
Plasma interleukin-1 beta may influence sepsis mortality, yet recombinant human receptor antagonist did not reduce mortality in randomized trials. We tested for heterogeneity the treatment effect of by baseline plasma or concentration.Retrospective subgroup analysis controlled trial.Multicenter North American and European clinical trial.Five hundred twenty-nine subjects with hypotension hypoperfusion, representing 59% original trial population.Random assignment placebo × 72 hours.We measured...
Objectives: Septic shock is associated with increased long-term morbidity and mortality. However, little known about the use of hospital-based acute care in survivors after hospital discharge. The objectives study were to examine frequency, timing, causes, risk factors emergency department visits readmissions within 30 days Design: Retrospective cohort study. Setting: Tertiary, academic United States. Patients: Patients admitted septic (serum lactate ≥ 4 mmol/L or refractory hypotension)...
Acute respiratory distress syndrome (ARDS) lacks known causal biomarkers. Plasma concentrations of sRAGE (soluble receptor for advanced glycation end products) strongly associate with ARDS risk. However, whether plasma contributes causally to remains unknown.
Abstract Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes neutrophils, NK cells, monocytes during COVID-19, suggesting excessive mobilization innate lineages. found marked activation within T B highly oligoclonal cell populations, profound plasmablast...
Cancer patients have increased morbidity and mortality from Coronavirus Disease 2019 (COVID-19), but the underlying immune mechanisms are unknown. In a cohort of 100 cancer hospitalized for COVID-19 at University Pennsylvania Health System, we found that with hematologic cancers had significantly higher relative to solid after accounting confounders including ECOG performance status active status. We performed flow cytometric serologic analyses 106 113 non-cancer controls two additional...
Thousands of biomarker tests are either available or under development for lung diseases. In many cases, adoption these into clinical practice is outpacing the generation and evaluation sufficient data to determine utility ability improve health outcomes. There a need systematically organized report that provides guidance on how understand evaluate use diseases.We assembled diverse group clinicians researchers from American Thoracic Society leaders National Heart, Lung, Blood Institute with...
Genetic factors are involved in acute respiratory distress syndrome (ARDS) susceptibility. Identification of novel candidate genes associated with increased risk and severity will improve our understanding ARDS pathophysiology enhance efforts to develop preventive therapeutic approaches.
ABSTRACT Background: Matrix Metalloproteinases (MMP) respond to tissue damage during sepsis. Higher plasma concentrations of MMPs and the tissue-inhibitor matrix metalloproteinases (TIMP) have been reported in sepsis compared with healthy controls. The objective this study was examine if levels MMP-3, MMP-9, TIMP-1 associate mortality organ dysfunction Methods: We conducted a prospective cohort critically ill patients adjudicated per Sepsis-3 criteria at tertiary academic medical center....
Hospital readmissions are common, expensive, and increasingly used as a metric for assessing quality of care. The relationship between index hospitalizations specific outcomes among those readmitted remains largely unknown.Identify risk factors present during the hospitalization associated with death or transition to hospice care 30-day examine contribution infection in resulting death.Retrospective cohort study.A total 17,716 an academic health system.We mixed-effects multivariable logistic...
OBJECTIVES: COVID-19 is a heterogenous disease. Biomarker-based approaches may identify patients at risk for severe disease, who be more likely to benefit from specific therapies. Our objective was and validate plasma protein signature COVID-19. DESIGN: Prospective observational cohort study. SETTING: Two hospitals in the United States. PATIENTS: One hundred sixty-seven hospitalized adults with INTERVENTION: None. MEASUREMENTS AND MAIN RESULTS: We measured 713 proteins 167 using...