A5101916991- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- Cancer-related Molecular Pathways
- Medicinal Plants and Neuroprotection
- Mast cells and histamine
- Cancer, Stress, Anesthesia, and Immune Response
- Eicosanoids and Hypertension Pharmacology
- Ubiquitin and proteasome pathways
- Heme Oxygenase-1 and Carbon Monoxide
- Wnt/β-catenin signaling in development and cancer
- Phytochemical compounds biological activities
- Cell Adhesion Molecules Research
- Flavonoids in Medical Research
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2024
Chongqing Medical University
2015-2024
Molecular Oncology (United States)
2020-2024
The University of Texas MD Anderson Cancer Center
2018-2022
Shandong First Medical University
2020
Shandong Provincial Hospital
2020
Shangqiu Normal University
2009-2016
Chongqing Medical and Pharmaceutical College
2007-2010
National Animal Husbandry Service
2008
Heritage Christian University
2001
Steroid hormone receptors, including estrogen receptor (ER) and progesterone (PR), are crucial biomarkers in breast cancer (BC). However, limited data available regarding single receptor-positive (ER-positive/PR-negative ER-negative/PR-positive) subtypes, rendering treatment decision survival forecast difficult patients with these BC subtypes.To investigate the clinicopathological characteristics BC-specific (BCSS) of BC.In this cohort study, on diagnosed between 1990 2015 were retrieved...
Despite the popular use of dietary supplements during conventional cancer treatments, their impacts on efficacies prevalent immunotherapies, including immune-checkpoint therapy (ICT), are unknown. Surprisingly, our analyses electronic health records revealed that ICT-treated patients with who took vitamin E (VitE) had significantly improved survival. In mouse models, VitE increased ICT antitumor efficacy, which depended dendritic cells (DC). entered DCs via SCARB1 receptor and restored...
Background: Since T cell exclusion contributes to tumor immune evasion and immunotherapy resistance, how improve infiltration into solid tumors becomes an urgent challenge. Methods: We employed deep learning profile the microenvironment (TIME) in triple negative breast cancer (TNBC) samples from TCGA datasets noticed that fibroblast growth factor receptor (FGFR) signaling pathways were enriched immune-excluded phenotype of TNBC. Erdafitinib, a selective FGFR inhibitor, was then used...
ABSTRACT Chrysin, a naturally occurring flavone, has been shown to inhibit cell proliferation and induce apoptosis in various cancers. However, the effect mechanisms of chrysin on cancer metastasis are still enigmatic. In this study, metastatic triple‐negative breast (TNBC) lines were used evaluate antimetastatic activity chrysin. The results showed that (5, 10 20 μM) significantly suppressed TNBC migration invasion dose‐dependent manner. Human matrix metalloproteinase (MMP) antibody array...
Although diallyl disulfide (DADS), an important garlic (Allium sativum) derivative, has exhibited potential anticancer activity, the molecular mechanism of this activity remains unknown. In study, we evaluated antitumor DADS in triple-negative breast cancer (TNBC) cell lines based vitro and vivo models.We found that treatment with resulted decreased viability, increased apoptosis, suppression metastatic TNBC cells. Furthermore, induced dysregulation B-cell lymphoma (Bcl)-2 family members,...
Tumor-associated macrophages (TAMs) promote cancer development and progression by releasing various cytokines chemokines.Previously, we have found that the number of COX-2 + TAMs was associated with lymph node metastasis in breast cancer.However, mechanism remains enigmatic.In this study, show enhances metastatic potential cells.COX-2 induces MMP-9 expression promotes epithelial-mesenchymal transition (EMT) cells.In addition, COX-2/PGE 2 IL-6 release macrophages.Furthermore, find activation...
Triple negative breast cancer (TNBC), characterized by its highly aggressive and metastatic features, is associated with poor prognosis high mortality partly due to lack of effective treatment. Fisetin, a natural flavonoid compound, has been demonstrated possess anti-cancer effects in various cancers. However, the mechanisms fisetin on metastasis TNBC remain uncovered. In this study, we found that dose-dependently inhibited cell proliferation, migration invasion lines MDA-MB-231 BT549 cells....
// Hongzhong Li 1 , Bing Yang Jing Huang Yong Lin Tingxiu Xiang Jingyuan Wan 2 Hongyuan Salem Chouaib 3 Guosheng Ren Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital Medical University, Chongqing, China Department Pharmacology, Unite INSERM U753, Institut de Cancerologie Gustave Roussy, Paris, France Correspondence to: Ren, e-mail: rengs726@126.com Keywords: tumor microenvironment, macrophages, breast cancer, cyclooxygenase-2, prostaglandin E...
E2Fs, as a family of pivotal transcription factors, have been implicated in multiple biological functions human cancer; however, the expression and prognostic significance E2Fs breast cancer remains unknown. In present study, mRNA patterns were investigated with Oncomine The Cancer Genome Atlas data. Prognostic values for patients determined using Kaplan‑Meier plotter database. results strongly indicated that E2F1, E2F2, E2F3, E2F5, E2F7 E2F8 overexpressed cancer, whereas E2F4 E2F6 exhibited...
This study was conducted to determine the role of neuregulin 1 (NRG1)-dependent human epidermal growth factor receptor 3 (HER3) activation in trastuzumab primary resistance, and observe inhibitory effect HER3 monoclonal antibody on HER2-overexpressing breast cancer cells. BT474 cells (trastuzumab sensitive) MDA-MB-453 resistant) were first stimulated with NRG1 then treated either trastuzumab, antibody, or a combination both. The expression phospho 2 (p-HER2), (p-HER3), protein kinase B...