A5072541699- Signaling Pathways in Disease
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Monoclonal and Polyclonal Antibodies Research
- Molecular Biology Techniques and Applications
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Kruppel-like factors research
- Cancer-related gene regulation
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Extracellular vesicles in disease
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2019
Peking Union Medical College Hospital
2019
Tumor-associated macrophages (TAMs), the main part of immune cells in tumor microenvironment (TME), play a potent role promoting tumorigenesis through mechanisms such as stimulating angiogenesis, enhancing migration and suppressing antitumor immunity. MicroRNAs (miRNAs) are considered crucial regulators multiple biological processes. The relationship between miRNAs function has been extensively reported, but roles that regulating TAMs phenotype remain unclear. In this study, we screened...
This study was conducted to determine the role of neuregulin 1 (NRG1)-dependent human epidermal growth factor receptor 3 (HER3) activation in trastuzumab primary resistance, and observe inhibitory effect HER3 monoclonal antibody on HER2-overexpressing breast cancer cells. BT474 cells (trastuzumab sensitive) MDA-MB-453 resistant) were first stimulated with NRG1 then treated either trastuzumab, antibody, or a combination both. The expression phospho 2 (p-HER2), (p-HER3), protein kinase B...
Considerable evidence suggests that proinflammatory pathways drive self-renewal of cancer stem-like cells (CSC), but the underlying mechanisms remain mainly undefined. Here we report let7 repressor LIN28B and its regulator IKBKB (IKKβ) sustain cell stemness by interacting with Wnt/TCF7L2 (TCF4) signaling pathway to promote progression. We found expression correlated clinical progression marker in breast patients. Functional studies demonstrated properties LIN28B-expressing human lung were...
Myogenic differentiation of skeletal muscle stem cells, also known satellite is tightly orchestrated by extrinsic and intrinsic regulators. Basic fibroblast growth factor (FGF2) well documented to be implicated in cell self-renewal repressing MyoD. We recently identified a MyoD-regulated muscle-specifically expressed long non-coding RNA Linc-RAM which enhances myogenic facilitating MyoD/Baf60c/Brg1 complex assembly. Herein, we investigated the transcriptional regulation intracellular...
Abstract Substantial evidence indicates that many human cancers are driven by a subpopulation of cells display stem cell properties. These cancer (CSCs) may also contribute to tumor metastasis and treatment resistance. It has been reported inflammatory factors in microenvironment activate NF-kB/IKK-β pathway which turn drive CSC self-renewal, but their molecular basis remain unclear. In this study, we demonstrated novel mechanism regarding Lin28B, RNA binding protein regulated IKK-β,...
Abstract TNF-related apoptosis-inducing ligand (TRAIL) receptor (DR4 or DR5) agonists are promising agents for cancer therapy because they induce apoptosis selectively in cells. However, their clinical effect is hampered by either primary acquired resistance Second mitochondria-derived activator of caspase (Smac) mimetics that antagonize the IAPs potently sensitize cells to TRAIL-induced a caspase-8-dependent manner. We evaluated antitumor effects small-molecule IAP antagonist...
<div>Abstract<p>Considerable evidence suggests that proinflammatory pathways drive self-renewal of cancer stem-like cells (CSC), but the underlying mechanisms remain mainly undefined. Here we report let7 repressor LIN28B and its regulator IKBKB (IKKβ) sustain cell stemness by interacting with Wnt/TCF7L2 (TCF4) signaling pathway to promote progression. We found expression correlated clinical progression marker in breast patients. Functional studies demonstrated properties...
<p>Supplementary Figure legend</p>
<p>Supplementary Figure 1. LIN28B expression correlated with stemness marker SOX2 in breast cancer tissues and clinical progress of lung patients. Supplementary 2. ALDH+ cells have propoties high human cells. 3. Tumor microenvironment activates IKKβ up-regulates 4. promotes the MCF-7 5. maintains H1299 tumor growth NOD/SCID mice. 6. up regulates sustains 7. TCF7L2 is required for mediated activation which Wnt/TCF7L2 signaling via direct binding to mRNA 8. IMD-0354 suppresses metastasis...
<p>Supplementary Figure 1. LIN28B expression correlated with stemness marker SOX2 in breast cancer tissues and clinical progress of lung patients. Supplementary 2. ALDH+ cells have propoties high human cells. 3. Tumor microenvironment activates IKKβ up-regulates 4. promotes the MCF-7 5. maintains H1299 tumor growth NOD/SCID mice. 6. up regulates sustains 7. TCF7L2 is required for mediated activation which Wnt/TCF7L2 signaling via direct binding to mRNA 8. IMD-0354 suppresses metastasis...
<p>Supplementary Figure legend</p>
<div>Abstract<p>Considerable evidence suggests that proinflammatory pathways drive self-renewal of cancer stem-like cells (CSC), but the underlying mechanisms remain mainly undefined. Here we report let7 repressor LIN28B and its regulator IKBKB (IKKβ) sustain cell stemness by interacting with Wnt/TCF7L2 (TCF4) signaling pathway to promote progression. We found expression correlated clinical progression marker in breast patients. Functional studies demonstrated properties...
Abstract Substantial evidences have proven that targeting cancer addictive metabolism could suppress tumor progression. Tumor microenvironment (TME) supports the development of metabolic reprograming cells. The function stem cells (CSCs) closely related with its own alteration. However, relationship between CSCs’ and their supportive TME, as well underlying mechanism remains largely unknown. In this study, we demonstrated a novel LIN28B/MYC positive regulation loop promote aerobic glycolysis...